Victims of child abuse may bear chemical marks on their genomes that alter the way they respond to stress as adults, according to a small study. Researchers say they detected changes, almost like genetic scars, to a region of the genome that either promotes or tamps down the expression of a certain gene involved in stress responses. This could help explain why childhood abuse, such as sexual abuse or neglect, can cause depression, other mental health effects and suicide, and could some day lead to treatments to help victims overcome their abusive childhoods [Reuters].
Researchers studied 36 brain samples from the Quebec Suicide Brain Bank: 12 from suicide victims who had been abused as children, 12 from suicide victims that suffered no known abuse, and a final 12 who died suddenly in accidents. They found that only the brains of abuse victims showed the changes.
The results are the latest exciting findings in the young field of epigenetics, the process by which environmental factors can alter the expression of genes. In epigenetic changes, the DNA sequence itself isn’t altered, but other mechanisms change certain genes’ activities. Psychiatrist Jonathan Mill says of the new study: “Whilst these results obviously need to be replicated, they provide a mechanism by which experiences early in life can have an effect on behaviour later in adulthood. The exciting thing about epigenetic alterations is that they are potentially reversible, and thus perhaps a future target for therapeutic intervention” [BBC News].
The study, reported in Nature Neuroscience, was the next step from an animal study that showed similar alterations in rats raised by neglectful mothers. Baby rats that were licked more – the rodent equivalent of hugs and good care – grew up to be more assertive and confident than unlicked pups. The researchers showed that neglect altered an important stress regulation gene in the rat brain, a change that lasted into adulthood [Canwest News Service].
Researchers say they hope these findings will point the way towards medical treatments that could repair damage done to the victims of abuse, but note that medication is not the only answer. In the neglected rat pups, the stress-related genes returned to their normal state of activation if those pups were transferred to more attentive mothers. “Just because there’s a biological effect doesn’t mean the only way you can intervene with drugs,” [comments psychologist Joan] Kaufman. Psychotherapy, for instance, has been shown to produce chemical changes in the brain [Nature News], and might have the same effect as medication.
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Image: iStockphoto
February 25th, 2009 at 10:35 am
As a victim of child abuse who still carries the eternal scars, this study is extremely eye opening and enlightening. As a victim, the physical damage ends, but the physiological, psychological and cognitive residual effects remain. At least now I know that there is science to support the way I struggle inside after all these years.
I can’t thank you enough for performing the study. Please continue to do your research. Millions of people, like me, now have hope that if there is a genetic alteration caused by abuse, there also may be a genetic alteration for the cure of the effects.
Todd Seyler
http://www.eloquentbooks.com/ChildAbuseandItsLifetimeofDemons.html
February 26th, 2009 at 2:34 pm
I am also a survivor of childhood abuse and have suffered severe clinical depression my entire adult life. I can’t help but wonder how different my adult life would have been had my genome not been altered by these earlier experiences.
February 26th, 2009 at 3:07 pm
A few days ago I heard in a Podcast that ALL suiciders’ brain had SOME kind of trace, which made it different from that of other people who died of natural causes.
I am beginning to think too may ¿¿¿¿¿scientists????? ¿¿¿¿¿researchers?????? just writing out nice, cute ideas not properly backed up by a serious experimenting and statistics.
February 26th, 2009 at 3:58 pm
I also want to thank you for writing this. And I TOTALLY agree with Joan Kaufman, there are ways to alter the cells without drugs and to find healing. If you are a victim looking for healing, I’d suggest looking into Journey work. I am a practitioner and have worked with people in this area. The results are amazing and I always see a shift in the person I am working with. You can look for a practitioner in your area by going to http://www.thejourney-usa.com
February 26th, 2009 at 7:17 pm
Also a survivor of childhood abuse, I tried for 40 years to find a way to heal the psychological, cognitive and spiritual effects (whatever you want to call them)….without real success. Some years ago I stumbled upon a modality which really addresses and deals with the abuse. This modality is called The Journey (developed by Brandon Bays). It uses guided introspection to allow the body’s own wisdom to address what needs to be addressed and the practitioner guides the process. It works!!! Gone are the symptoms I have carried my whole life (in spite of years of conventional therapy and years of study). When horrible things happen – the horror, the emotions stick in that cellular memory and we function through the filters of the abuse. The Journey techniques allow those stuck emotions to release so that one no longer has to function though all that old dis-ease. This technique seems to be well known in Europe, UK, Australia, NZ and is even being used in some schools in S Africa. If genes are the blueprint, this technique certainly seems to clean and clear the blueprint so that there can be cellular reproduction without the dis-ease. which has always before been so permanently crippling.
April 5th, 2009 at 3:49 am
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April 29th, 2009 at 11:51 am
This article just justifies the real importance of Epigenetic.
September 10th, 2009 at 11:06 pm
Last week I was at the shops and I saw this woman with her two kids she snatched the money out of their hands turned to the othr girl and seethed in her face somthin close to the lines of ‘you are an ungrateful f****** b**** …you are a f****** cow’ physical abuse is bad enough but to verbally abuse a kid like that is disgusting. Both girls were cryin but this one was shaking and was hysterically crying she was cowering and coverin her face. I dont give a shit if that socalled mum reads this I hope she does and people like her do. Shame on all of you who abuse your own kids.It is wrong and pathetic.Its revolting.I despise you people.Child abuse is one of the reasons why I am not proud to be an australian.We have all these ’security’ guards and these so called authorities and practically all the time they do nothin but watch.A ‘parent’ can be right there in front of them smackin their kid or swearin and carrying on at them and these morans do nothing. Twice I’ve tried confronting these socalled parents but nothin helped.These people who are meant to be the authorities can do more they are just lazy.Another thing I hate seein and just knowing it goes on is ‘parents’who threaten to and do smack their kids bums . To smack a childs bum is sexual harrassment,it is the worst area to smack a child because their bums are their genitals,it is their private area and whenever I hear a ‘parent/s’ use this threat or I see them administer it I feel like belting them.They have absolutely no right whatsoever to make threats like that let alone do it actions that are so disgusting.Abuse is abuse in no matter what form. To smack a kid on their nappy is abuse, and kids dont need to feel the sting to be abused its the intention these morans have behind it.People who go to smack or tap their kids in the name of a’parental right’ or ‘discipline’are being abusive.A kid goes to put their hand on a stove or something,you should be hit or somethin for your lack of supervision, same thing when a kid goes to cross the road,you should cop it for your lack of supervision, not the child.So screw you abusers,screw the lot of you. You people are pathetic and dont deserve children when you treat them like shit.