A Life-Extending Coup: Flies That Can't Smell Food Live 30 Percent Longer

By Smriti Rao | April 21, 2010 2:23 pm

sn-aging-thumb-200xauto-306In today’s edition of far-out science, researchers have found evidence that the wafting aroma of food has an effect on an organism’s lifespan–and they’ve demonstrated that interfering with a fruit fly’s sense of smell causes it to live a longer, healthier life. While there’s no guarantee that the trick would work for humans, optimistic researchers suggest that certain odors—or drugs that block us from sensing them—might one day help prevent disease and extend lives [ScienceNOW].

In the past decade, scientists have established a clear connection between extremely low-calorie diets and extended lifespans; studies have demonstrated that yeast, fruit flies, mice, and monkeys on these diets live longer than their peers. While the exact mechanism at work isn’t yet clear, researchers suspect that a near-starvation diet causes an organism’s metabolism to slow down, and triggers other changes that evolved to help organisms survive in times when food was scarce. Now scientists say it may not be just what a creature eats, but also what it smells that has an effect on how long it lives.

In one 2007 study, molecular biologist Scott Pletcher and his colleagues found that completely eliminating fruit flies’ sense of smell caused them to live nearly 20 percent longer than normal flies. They also found that wafting the smell of yeast, a tasty treat for fruit flies, towards flies that were on a low-cal, live-extending diet hastened the death of those flies. This led the scientist to hypothesize that specific odors might be influencing the flies’ lifespans. Luckily, other scientists had identified a receptor in a group of neurons that enable fruit flies to smell carbon dioxide, which signals the presence of a good meal of tasty yeast [ScienceNOW]. So, Pletcher and his team set out to find if the CO2 had anything to do with the duration of the flies’ lives.

For the new study published in PloS Biology, Pletcher eliminated the fruit flies’ ability to smell carbon dioxide, while keeping the rest of the olfactory system intact. Even on a standard, full-calorie diet, the flies that couldn’t detect CO2 lived up to 30 percent longer than other flies. The researchers suggest that the absense of CO2 may have indicated to the altered flies that food was scarce in the environment, prompting them to snap into survival mode. Oddly, however, the life-extending effect was only seen in female flies–male flies gained no such benefit. The smell-deprived female flies also seemed healthier and stronger by several measures: They stored extra fat, produced more offspring, and proved to be more resistant to oxidative stress than normal flies.

Pletcher isn’t sure how the inability to smell CO2 extended the females’ lifespans, but he says the findings open up fascinating new areas for studies of human aging. He suggests that there might be certain smells or drugs that would block certain odors, and which could give humans a bit more time before we shuffle off our mortal coils. Matt Karberlein, an aging expert who wasn’t involved in Pletcher’s research, was cautiously optimistic about that possibility, saying: “We definitely undergo physiological changes in response to smelling food – I’m getting hungry just thinking about it – so I think it’s possible” [New Scientist].

Related Content:
80beats: A Single Genetic Tweak Gives Mice Longer, Healthier Lives
80beats: Low-Calorie Diet Staves off Aging & Death in Monkeys
Not Exactly Rocket Science: Low-calorie diets improve memory in old age
DISCOVER: In Worms, a New Theory on Aging

Image: Scott Pletcher / University of Michigan, Ann Arbor

CATEGORIZED UNDER: Health & Medicine, Living World
  • ChH

    If the odor that has to be eliminated for longer human lifespan is that of fried bacon … that’s gonna be a tough choice.

  • jumblepudding

    Couldn’t they modify the underlying pathway rather than blocking smell itself, or is it just too hardwired-I smell food, this means life is good, this means cut down on survival mechanisms and pig out.

  • Rosie R

    This could potentially be really GOOD NEWS for me, as I lost my sense of smell completely in a head injury 21 years ago!!!

  • Ramo D

    Isn’t the sense of smell directly correlated to the sense of taste?
    Therefore, no smell = no taste?

  • Uncle B

    You mean the great fatted calves of America, the fattest asses in humanity , won’t live as long? Good on them!

  • http://improvevision.livejournal.com/ improve eyesight

    Trust a accomplished site developer. Your website surfaces all over the internet, you must be performing all the correct things. Developing such a grassroots website is not simple. Thought I would connect in and link to you.

  • http://nuclearmedicinetechnologistjobs.net medicine technologist

    Nuclear medication is a technology that offers info in regards to the framework and perform of every organ. It involves the administration of radio energetic substances within the human body to visualize the capabilities from the organs. They’re carried out by technicians who’ve mastered nuclear medicine technologies. A nuclear medication technologist administers these medicines to the individuals as directed through the doctors.

NEW ON DISCOVER
OPEN
CITIZEN SCIENCE
ADVERTISEMENT

Discover's Newsletter

Sign up to get the latest science news delivered weekly right to your inbox!

80beats

80beats is DISCOVER's news aggregator, weaving together the choicest tidbits from the best articles covering the day's most compelling topics.
ADVERTISEMENT

See More

ADVERTISEMENT
Collapse bottom bar
+

Login to your Account

X
E-mail address:
Password:
Remember me
Forgot your password?
No problem. Click here to have it e-mailed to you.

Not Registered Yet?

Register now for FREE. Registration only takes a few minutes to complete. Register now »