Darwin's Family May Have Paid a Price for Inbreeding

By Eliza Strickland | May 4, 2010 5:04 pm

Charles_and_William_DarwinCharles Darwin may have been right in worrying that the ill health that plagued his family were a result of inbreeding. Darwin didn’t only marry his first cousin, Emma Wedgwood–in fact, the Darwins and the Wedgwoods made a habit of intermarrying (Darwin’s maternal grandparents were also third cousins). Now a new study, which crunched the numbers on first-cousin marriages over four generations of the two dynasties, suggests that his children had an elevated risk of health problems.

The degree of inbreeding among Darwin’s children, while not excessive, was enough to increase the risk of recessive diseases — ones that occur if a harmful version of a gene is inherited from both parents. Three of his 10 children died before age 10 — 2 of bacterial diseases. Childhood mortality from bacterial infections is associated with inbreeding. So, too, is infertility, and three of Darwin’s children who had long marriages left no children [The New York Times].

The study (pdf), published in the journal BioScience, serves as an ironic footnote to the work of the great evolutionary biologist.

Charles Darwin’s studies of heredity, adaptation and evolution included many experiments into the effects of crossbreeding and inbreeding in both plants and animals. Such consanguineous pairing often resulted in weaker, more sickly descendants [Scientific American].

And Darwin wasn’t blind to the possible implications of his studies; in his letters he wrote of “the evil effects of close interbreeding” and worried that this problem might be playing out in his own family.

Other genetic researchers have argued in recent years that cousin marriages, which are banned in many parts of the world, don’t actually pose enough of a health threat to justify the bans; but that argument dealt only with infrequent cousin marriages, not consistent patterns of inbreeding.

Related Content:
80beats: What Killed King Tut? Incest and Malaria, Study Says
80beats: Cousin Marriages May Be Taboo, but They’re Not Genetic Disasters
80beats: Darwin Goes Digital for 150th Anniversary of “On the Origin of Species”
80beats: Darwin’s Anti-Slavery Views May Have Guided His Theory of Evolution
DISCOVER: Go Ahead, Kiss Your Cousin

Image: Wikimedia

  • http://drvitelli.typepad.com Romeo Vitelli

    There’s a certain irony in the fact that Darwin’s cousin, Francis Galton, invented eugenics. At least Charles Darwin didn’t go along with that notion (although his son did).

    http://drvitelli.typepad.com/providentia/2009/10/saving-civilization.html

  • Peepors

    He’s still my Hero. He’s the only one of his time that shaped the world of science and understanding, that beyond our box of god, there is a world much greater and far more advanced than a few pages written by some weirdos without a name.

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