Could Connection-Mapping Brain Scans Help Diagnose Autism?

By Andrew Moseman | September 10, 2010 11:04 am

dosenbach2HRYour pencil marks on the door frame mark your kids’ ascending height; your photo albums carry the visual record of their ascending ages. Scientists have figured out a new way to track growing up: studying the normal evolution of connections between parts of the brain as a person ages toward adulthood. If advanced far enough, such a method could even help to catch developmental disability.

In a study out this week in Science, the team led by Nico Dosenbach outline the technique based on functional connectivity MRI, or fcMRI. Where the MRI scans we cover more frequently typically reveal brain structure or activity in a particular region, fcMRI focuses on the connections across the brain.

The research team scanned the brains … of 238 normally developing subjects aged 7 to 30, for five minutes. By comparing 200 of 12,720 key functional brain connections and assessing them through multivariate pattern analysis, researchers then predicted volunteer subjects’ developmental status. [Scientific American]

In this early test of the system, Dosenbach and his colleagues say they could differentiate a child’s brain from an adult’s more than 90 percent of the time simply by looking at the connections. Comparing adults to adolescents, they got it right three-quarters of the time.

Here’s why it’s important: As people age from child to adult, the general trend in the brain is to move from from a host of links going every which way to fewer total connections, but longer and stronger ones. If a system like Dosenbach’s could be refined so the scan places a person’s brain on that curve with great accuracy, you might be able to see places where a person’s brain maturity lags behind their body maturity. Dosenbach says that could be a tool to help pick out developmental disabilities like autism.

Many children with severe behavioral or learning problems get traditional MRI, Dosenbach says. But their scans usually appear normal, he says. That’s because the problem isn’t usually with the brain structures themselves. Instead, the trouble comes from the way those structures are communicating with each other. [NPR]

But could this technology have darker ramifications? The Washington Post is all atwitter about the unintended consequences of possessing the power to gauge someone’s mental maturity:

Will overly anxious or competitive parents demand that their children be tested to see how they score compared with their peers? Or to help them decide whether children are mature enough, for example, to leave home for college? Will online dating services offer brain scans rating the maturity of potential mates? Will defense lawyers try to use scans to prove their young clients aren’t mature enough to be tried as adults? Or will prosecutors cite the scans to prove the opposite? [Washington Post]

We don’t have to deal with those issues quite yet, but we will have to deal with them at some point. Just look at all the lawyers this year attempting to enter fMRI scans as evidence as court.

Related Content:
DISCOVER: How Autistic Artists See the World (PHOTOS)
DISCOVER: The Pugnacious Paper That Aims To Turn Neuroscience on its Head
80beats: Big Autism Study Reveals New Genetic Clues, but Also Baffling Complexity
80beats: Federal Judge: Brain Scans Not Welcome as Lie-Detecting Evidence

Image: Science / AAAS

MORE ABOUT: autism, brain, MRI
  • Marcia shortskirt

    Related to this I read a really interesting book predicting this very finding in a very Canadian way. It uses McLuhanism, systems theory, Jane Jacobs, chaos theory, family dynamics and “Life of Brian” to predict that a non-inherited and increasingly common x chromosome mutation would be responsible for some cases of Autism. I read it because it was interesting without really guessing it would actually be right. It also predicts a steady slow but geometric rise in cases and outlines a framework based on feedback and systems theory for where to look for the other 85% of the causes. It also goes through a- whole bunch of other subjects like God, beauty, pattern recognition (really interesting) and actually quite a bit more. Unusual name of Xzenobia, just like the book, really different.

  • ca guardcard

    This entry was good but, more details would be even better.


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