Does a Common Cold Virus Boost Chances of Childhood Obesity?

By Jennifer Welsh | September 21, 2010 8:21 am

sick-kidA study of children has discovered a correlation between obesity and prior infection with a cold virus, called Adenovirus 36. While the link is fairly weak, the tantalizing research suggests a new front on the war on obesity.

The study participants included 124 children between the ages of 8 and 18. Of the 67 obese children involved in the study, 15 had signs of previous infection with the AD36 virus, in comparison with only 4 of the 57 non-obese children. The study was published in the online edition of Pediatrics.

The children who had been previously exposed to the virus (which was indicated by the antibodies to the virus present in their blood) were on average 50 pounds heavier than the non-exposed children. And even within the obese group, those that had been previously exposed to AD36 were an average of 35 pounds heavier.

It is not clear to what extent the virus can be used to explain the epidemic proportions of western obesity when compared to other factors such as lack of exercise and poor diet. Study leader Dr Jeffrey Schwimmer said: “It is time that we moved away from assigning blame in favour of developing a level of understanding that will better support efforts at both prevention and treatment, these data add credence to the concept that an infection can be a cause or contributor to obesity.” [The Telegraph]

AD36, which can cause respiratory infections and gastrointestinal upset, has been fingered in studies of obesity before. The virus has previously been found in fat cells in animal and cell culture models, and it had been hypothesized that this might be the way in which the virus contributes to obesity.

Chickens, mice, rats and monkeys infected with the virus all get fat even though the animals don’t eat more or exercise less than they did before they were infected…. Experiments on human cells in laboratory dishes explain how the virus promotes weight gain — adult stem cells infected with the virus make more fat cells, and those fat cells store more fat. [Science News]

Researchers caution that while the virus could play a role in obesity for some people, the causes of obesity are most likely different for everyone. Not everyone who gets this common virus becomes obese, and not everyone who is obese has been exposed to this virus. Even if a definite connection is proven between the virus and obesity, there is no telling which causes the other.

Dr. Goutham Rao, clinical director of the Weight Management and Wellness Center at Children’s Hospital of Pittsburgh, said the findings bring up the “age-old chicken or egg problem — Does this virus disrupt certain pathways and cause obesity? Or, do obese kids tend to have this virus more often?” [Businessweek]

The researchers behind the current study acknowledge that they haven’t yet proven that the virus causes obesity, and point out another possibility: Childhood obesity could weaken the immune system, which would make obese children more susceptible to getting the AD36 virus.

But if infection with the virus does lead to obesity in some people, it might lead to new strategies to treating some obese patients. As Nikhil Dhurandhar, who wasn’t involved in the current study and who works on what he calls “infectobesity” at the Pennington Biomedical Research Center, says:

“If there’s at least some part of obesity that is caused by infections, then there is a potential to have a vaccine to prevent this type of obesity.” [FOX News]

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Discoblog: Army Generals Fret: Are Americans too Fat to Fight?

Image: iStockphoto

CATEGORIZED UNDER: Health & Medicine
MORE ABOUT: obesity, viruses
  • Megan S

    Children who are not breastfed or are not breasfed for a significant period of time contract increased numbers of colds in their early years!

    There is already a clear link between formula feeding and obesity, maybe this is tied into it?

    Can’t keep the scientist out of this SAHM for long!

  • Dante The Canadian

    Orrrrrrrrrrrrr childhood obesity in otherwise healthy children is caused by kids who are fed too much fatty, processed, sugar and starch laced foods. Could it also be that childhood obesity is caused in conjunction with a lack of exercise?????? Unless a child has a glandular issue, the childs obesity mirrors why adult obesity rates have skyrocketed.

    1. Poor Diet.
    2. Lack of exercise

    That’s it. Let’s quit always trying to blame a virus or a bacteria for our issues. The reason why kids and adults are obese is because of OUR LIFESTYLES and nothing else.

  • Rhacodactylus

    Dante, it is very true that we can attribute much of the obesity problem to lifestyle, but it’s ridiculous to turn a blind eye to science which could help the situation. And, seems like an odd tack for someone on a science blog to take.

  • Jennifer Welsh

    Hey all,

    Thanks for your comments.

    I want to reiterate that even though these researchers are saying this could be a POSSIBLE FACTOR contributing to childhood obesity, they aren’t saying it is the only factor, or the factor for all obese children, or adults for that matter. For many people it is possible, if not likely, that a healthier lifestyle will solve many of their obesity issues.

    Because of discoveries like this, which could help us understand why some people have a harder time loosing weight and keeping it off, doctors could develop new ways to treat people who have been exposed to this virus, if it is discovered to be a causative factor.


  • JD

    Your title should read Does child obesity boost the chances of the common cold virus. Obesity is the problem that causes havoc with our bodies not the other way around!

  • nick

    I think it much more likely that poor diet and lack of exercise causes reduced immune system function, as the researchers state in the article. That seems to pass the Occam’s razor test a bit better than the much more hyped part of the article.

  • Jennifer Welsh

    JD and Nick,

    Thanks for your comments. I agree that its an incredibly valid point that this correlation could happen the other way around, but there are some interesting animal and cell culture experiments that have been done which seem to point the other way. It will be interesting to see how future research pans out!


  • Ed Cash

    About the “chicken or egg issue” Continue the study, concentrating on the chldren without the correlation.

    Do the currently nonobese adenovirus 36-positive children have an increased rate of obesity in the future?

    Do the obese children who are not adenovirus 36-positive have an increased rate of adenovirus-36 positive results?

    Seems to me it was once thought that bacterial infections caused all diseases. It turned out they didn’t. Diet and exercise may not be the only answer.

  • Dr. Victor Ong YC

    After reading this article, take a look at pages 29-31 of the book ‘Aetiology of Individual Obesities – A Brief Introduction to Causal Clusters’, 2008, Armour Publishing. It will help you put everything in perspective.


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