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	<title>Comments on: Study: Placebos Can Work Even if Patients Know They&#039;re Placebos</title>
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	<link>http://blogs.discovermagazine.com/80beats/2010/12/27/study-placebos-can-work-even-if-patients-know-theyre-placebos/</link>
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		<title>By: Marc</title>
		<link>http://blogs.discovermagazine.com/80beats/2010/12/27/study-placebos-can-work-even-if-patients-know-theyre-placebos/#comment-24431</link>
		<dc:creator>Marc</dc:creator>
		<pubDate>Tue, 28 Dec 2010 14:35:27 +0000</pubDate>
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		<description>Orac&#039;s take is at http://www.sciencebasedmedicine.org/?p=9339.  Highly recommended.  In particular, note that although the researchers told the patients that the placebos were inert, they also followed a script designed to make that description meaningless in terms of generating a placebo effect:

&quot;The provider clearly explained that the placebo pill was an inactive (i.e., “inert”) substance like a sugar pill that contained no medication and then explained in an approximately fifteen minute a priori script the following “four discussion points:” 1) the placebo effect is powerful, 2) the body can automatically respond to taking placebo pills like Pavlov’s dogs who salivated when they heard a bell, 3) a positive attitude helps but is not necessary, and 4) taking the pills faithfully is critical. &quot;

So you tell the patient it is a sugar pill in 30 seconds, then spend 15 minutes convincing him that placebos are really significant and powerful medicine and taking them is critical to them getting benefit, and then you&#039;re shocked that you have a moderate result of benefit?  Sounds like some of the people being fooled some of the time to me.</description>
		<content:encoded><![CDATA[<p>Orac&#8217;s take is at <a href="http://www.sciencebasedmedicine.org/?p=9339" rel="nofollow">http://www.sciencebasedmedicine.org/?p=9339</a>.  Highly recommended.  In particular, note that although the researchers told the patients that the placebos were inert, they also followed a script designed to make that description meaningless in terms of generating a placebo effect:</p>
<p>&#8220;The provider clearly explained that the placebo pill was an inactive (i.e., “inert”) substance like a sugar pill that contained no medication and then explained in an approximately fifteen minute a priori script the following “four discussion points:” 1) the placebo effect is powerful, 2) the body can automatically respond to taking placebo pills like Pavlov’s dogs who salivated when they heard a bell, 3) a positive attitude helps but is not necessary, and 4) taking the pills faithfully is critical. &#8221;</p>
<p>So you tell the patient it is a sugar pill in 30 seconds, then spend 15 minutes convincing him that placebos are really significant and powerful medicine and taking them is critical to them getting benefit, and then you&#8217;re shocked that you have a moderate result of benefit?  Sounds like some of the people being fooled some of the time to me.</p>
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		<title>By: Chris Caprette</title>
		<link>http://blogs.discovermagazine.com/80beats/2010/12/27/study-placebos-can-work-even-if-patients-know-theyre-placebos/#comment-24430</link>
		<dc:creator>Chris Caprette</dc:creator>
		<pubDate>Mon, 27 Dec 2010 16:11:33 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=24164#comment-24430</guid>
		<description>Please read Orac&#039;s takedown of this study at &lt;a href=&quot;http://scienceblogs.com/insolence/2010/12/more_dubious_statements_about_placebo_ef.php&quot; rel=&quot;nofollow&quot;&gt;Respectful Insolence&lt;/a&gt;. The study was rather seriously flawed.</description>
		<content:encoded><![CDATA[<p>Please read Orac&#8217;s takedown of this study at <a href="http://scienceblogs.com/insolence/2010/12/more_dubious_statements_about_placebo_ef.php" rel="nofollow">Respectful Insolence</a>. The study was rather seriously flawed.</p>
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