Bacteria Evade Antibiotics by Going Incognito

By Veronique Greenwood | April 30, 2011 9:24 am

ecoli

What’s the News: Going undercover can require some sacrifices–burning off your fingerprints, for instance, a la Gattaca. It’s the same story with bacteria: they can slip below antibiotics’ radar without any mutations, but only using an elaborate system of self-sabotage. A new study reveals the workings of this biochemical disguise.

How the Heck:

  • When antibiotics are floating around, they activate a stress response in bacteria. Part of that response, the team found, is the actions of a toxin and its antidote.
  • When the bacterium isn’t stressed, the antidote keeps the toxin in check. But when stress hits, the antidote is destroyed, allowing the toxin to ravage the inner workings of the bacterial cell. It shreds the bacterium’s mRNA, the DNA transcripts needed to build new proteins, and the cell goes into lockdown.
  • Because it’s no longer showing signs of life, drugs pass over the dormant bacterium. When the antibiotic is gone, the bacterial stress response subsides, the toxin is reined back in, and the bacterium reawakens.

What’s the Context:

  • Toxin-antidote pairs have always been something of an enigma for biologists. Why, they wonder, would bacteria go around carrying the cellular equivalent of a loaded gun? This study provides one possible answer: the gun lets them fake their death when the going gets tough.
  • Antibiotic resistance is a serious problem (just a few weeks ago, a gene that confers resistance to 14 antibiotics was found in New Delhi’s water supply), but mutations are the most well-known way for that to happen. Knowing that bacteria are using multiple strategies to dodge drugs suggests new possibilities for addressing it.

The Future Holds: The development of next-generation drugs that can flush dormant bacteria out. A two-drug combo of an antibiotic and a chemical that wakes bacteria up could be a potent solution, suggest the researchers.

Reference: Xiaoxue Wang, Younghoon Kim, Seok Hoon Hong, Qun Ma, Breann L Brown, Mingming Pu, Aaron M Tarone, Michael J Benedik, Wolfgang Peti, Rebecca Page, Thomas K Wood. Antitoxin MqsA helps mediate the bacterial general stress response. Nature Chemical Biology, 2011; doi:10.1038/nchembio.560

Image credit: Wikimedia Commons

CATEGORIZED UNDER: Health & Medicine, Living World
  • Ajay

    Well, that’s something interesting. Hope we make ‘Future drugs’ soon

  • Phil Harriman

    One bacterial toxin-antidote pair has been explained as a kind of selfish DNA. E. coli Bacteriophage P1 encodes a restriction nuclease and a methylase that protects the host from the nuclease when the phage is acquired as a cytoplasmic prophage. Occasionally a copy of the prophage doesn’t make it into a daughter cell. Those cells can outcompete the bacteria still carrying the prophage. However, the methylase activity dilutes out faster than the nuclease activity as the cells divide, eventually leading to destruction of the DNA of the cells that have lost the prophage.
    It looks like the prophage isn’t completely selfish in that the restriction-modification system can protect its host cell (and itself) from foreign DNA that could infect the cell.

  • T. Dougherty

    This builds on work that goes all the way back into the mid-1980′s conducted by the late Harris Moyed. He was the first to show that there was a genetic basis for bacterial persistance with the discovery of the hipAB genes. This was the first of several toxin-antitoxin pairs discovered.

NEW ON DISCOVER
OPEN
CITIZEN SCIENCE
ADVERTISEMENT

Discover's Newsletter

Sign up to get the latest science news delivered weekly right to your inbox!

80beats

80beats is DISCOVER's news aggregator, weaving together the choicest tidbits from the best articles covering the day's most compelling topics.
ADVERTISEMENT

See More

ADVERTISEMENT
Collapse bottom bar
+

Login to your Account

X
E-mail address:
Password:
Remember me
Forgot your password?
No problem. Click here to have it e-mailed to you.

Not Registered Yet?

Register now for FREE. Registration only takes a few minutes to complete. Register now »