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	<title>Comments on: New Vaccine Curbs Heroin Addiction in Rats</title>
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	<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/</link>
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		<title>By: Ben</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28637</link>
		<dc:creator>Ben</dc:creator>
		<pubDate>Fri, 24 Feb 2012 16:44:42 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28637</guid>
		<description>To the person in the second comment:

i realize this is late, but here we go. Our body doesnt release &quot;natural opiates&quot; our body releases neural transmitters called &quot;endorphins&quot;. Those endorphins tell the nerves that report pain that there is no pain, in order to maintain homeastatis(a balance in the body). Opiates cause our body to unnaturally release these endorphins in an unbelievably unnatural way.

Addiction to these drugs comes from upon using these drug periodically, our body no longer naturally releases these endorphins and waits for the drug to be administered. So, when the drug is not in your system, no endorphins are being released and paiin is uncontrollableand homeostasis does not exist. this means that a simple pinches pain can feel like your skin is being ripped off because your body cant control the pain.

Think about the cruise control on your car. Your car is set to 60, but when it drops to 58 it gives a little gas. Now inject your car with heroin. It accelerates to 90 and then goes to 55. you inject again to get to 60 but it puts you back up to 85. You now drop to 50 when the your car is sober. In this comparison, anything below 60 is pain and 90 is high. With every use, the speed while not using is lower and lower, while it is utterly inpossible to keep at a normal speed.

I am acollege student, btw, and i learned all about this in my anatomy class. unfortunately, my brother is also a herion addict and is homeless. I do not know where he is and i only occasionally hear that he is actually alive, i never speak to him directly. I&#039;ve been researching ways that i can help him, but it seems that there is nothing i can do for him. im nineteen and have never touched a drug in my life so i do not KNOW what anyone is going through. I just know what im going through. And just the fact of not knowing whether my own brother is alive or dead is agonizing in itself.</description>
		<content:encoded><![CDATA[<p>To the person in the second comment:</p>
<p>i realize this is late, but here we go. Our body doesnt release &#8220;natural opiates&#8221; our body releases neural transmitters called &#8220;endorphins&#8221;. Those endorphins tell the nerves that report pain that there is no pain, in order to maintain homeastatis(a balance in the body). Opiates cause our body to unnaturally release these endorphins in an unbelievably unnatural way.</p>
<p>Addiction to these drugs comes from upon using these drug periodically, our body no longer naturally releases these endorphins and waits for the drug to be administered. So, when the drug is not in your system, no endorphins are being released and paiin is uncontrollableand homeostasis does not exist. this means that a simple pinches pain can feel like your skin is being ripped off because your body cant control the pain.</p>
<p>Think about the cruise control on your car. Your car is set to 60, but when it drops to 58 it gives a little gas. Now inject your car with heroin. It accelerates to 90 and then goes to 55. you inject again to get to 60 but it puts you back up to 85. You now drop to 50 when the your car is sober. In this comparison, anything below 60 is pain and 90 is high. With every use, the speed while not using is lower and lower, while it is utterly inpossible to keep at a normal speed.</p>
<p>I am acollege student, btw, and i learned all about this in my anatomy class. unfortunately, my brother is also a herion addict and is homeless. I do not know where he is and i only occasionally hear that he is actually alive, i never speak to him directly. I&#8217;ve been researching ways that i can help him, but it seems that there is nothing i can do for him. im nineteen and have never touched a drug in my life so i do not KNOW what anyone is going through. I just know what im going through. And just the fact of not knowing whether my own brother is alive or dead is agonizing in itself.</p>
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		<title>By: Oddone</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28636</link>
		<dc:creator>Oddone</dc:creator>
		<pubDate>Wed, 08 Feb 2012 01:56:43 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28636</guid>
		<description>In regards to the first two comments about pain cessation I would say that IDEALLY the administration of opiates to a recreational user or an addict would be avoided - particularly for someone who is a sober, non - using addict.

Considering the risk of restarting the process of withdrawal and dramatically increased chance of relapse directly following the medical administration I would say it would be prefferable to use alternative means of treatment.</description>
		<content:encoded><![CDATA[<p>In regards to the first two comments about pain cessation I would say that IDEALLY the administration of opiates to a recreational user or an addict would be avoided &#8211; particularly for someone who is a sober, non &#8211; using addict.</p>
<p>Considering the risk of restarting the process of withdrawal and dramatically increased chance of relapse directly following the medical administration I would say it would be prefferable to use alternative means of treatment.</p>
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		<title>By: David</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28633</link>
		<dc:creator>David</dc:creator>
		<pubDate>Tue, 23 Aug 2011 21:11:50 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28633</guid>
		<description>This is interesting…
Overcoming Common Drug Rehab Problems
If you or a loved one is considering drug rehab, you may find that many day to day problems complicate your choice. Below are some concerns that come up regularly when a prospective patient is entering rehab and suggestions for how one might resolve these problems…
Go to valleyhope.org to read more.</description>
		<content:encoded><![CDATA[<p>This is interesting…<br />
Overcoming Common Drug Rehab Problems<br />
If you or a loved one is considering drug rehab, you may find that many day to day problems complicate your choice. Below are some concerns that come up regularly when a prospective patient is entering rehab and suggestions for how one might resolve these problems…<br />
Go to valleyhope.org to read more.</p>
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		<title>By: Claudio @ Crime in South Africa</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28632</link>
		<dc:creator>Claudio @ Crime in South Africa</dc:creator>
		<pubDate>Fri, 19 Aug 2011 10:19:40 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28632</guid>
		<description>I agree, i think the fact that rats have a limit to there phsycological being might not be accurate, but its a start atleast.</description>
		<content:encoded><![CDATA[<p>I agree, i think the fact that rats have a limit to there phsycological being might not be accurate, but its a start atleast.</p>
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		<title>By: Dim</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28631</link>
		<dc:creator>Dim</dc:creator>
		<pubDate>Mon, 25 Jul 2011 17:18:14 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28631</guid>
		<description>I think rats havn&#039;t phsycologic dependens, so in human&#039;s case it must be much difficult.</description>
		<content:encoded><![CDATA[<p>I think rats havn&#8217;t phsycologic dependens, so in human&#8217;s case it must be much difficult.</p>
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		<title>By: Sydney</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28630</link>
		<dc:creator>Sydney</dc:creator>
		<pubDate>Sun, 24 Jul 2011 21:20:22 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28630</guid>
		<description>As a practitioner of emergency medicine, I have to disagree with Naveed. One of the reasons for administering morphine or fentanyl in the field, for example in the case of acute MI (heart attack), is for its properties as a vaso-dilator, not just for pain relief. Opioid, opiate painkillers are indicated in and are included in the responsible treatment and management of certain conditions. Non-narcotic pharmaceutical preparations are not a substitute. One of the metabolites of heroin is morphine, and yes this would have an effect on therapeutic administration as well.</description>
		<content:encoded><![CDATA[<p>As a practitioner of emergency medicine, I have to disagree with Naveed. One of the reasons for administering morphine or fentanyl in the field, for example in the case of acute MI (heart attack), is for its properties as a vaso-dilator, not just for pain relief. Opioid, opiate painkillers are indicated in and are included in the responsible treatment and management of certain conditions. Non-narcotic pharmaceutical preparations are not a substitute. One of the metabolites of heroin is morphine, and yes this would have an effect on therapeutic administration as well.</p>
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		<title>By: Stupidity</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28629</link>
		<dc:creator>Stupidity</dc:creator>
		<pubDate>Sun, 24 Jul 2011 14:18:01 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28629</guid>
		<description>It seems to me that this would be very useful  for young people who do not believe they can be addicted to a drugs. Once addiction become obvious they can recieve a shot at a help center.</description>
		<content:encoded><![CDATA[<p>It seems to me that this would be very useful  for young people who do not believe they can be addicted to a drugs. Once addiction become obvious they can recieve a shot at a help center.</p>
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		<title>By: Naveed</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28628</link>
		<dc:creator>Naveed</dc:creator>
		<pubDate>Sun, 24 Jul 2011 03:38:35 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28628</guid>
		<description>Pietr, if it stops the heroin from working it is not a punishment. Who&#039;s talking about forcing them? I&#039;m sure there are a lot of addicts who would want to take this vaccine if it could stop them from taking heroin.

To Scott and Mountaindog, true it would stop them from being able to receive pain relief from other opiates, but I believe there are alternatives to opiates for pain cessation. I suppose people would have to choose if they want to remain a junkie, kill themselves slowly and live a miserable life or risk that under some uncertain circumstances they could not receive opiate painkillers. I know what I would choose, I would get rid of the pressing problem of being a heroin addict.

Let&#039;s look at the odds:
Chance of dying in a car accident in your lifetime: 1 in ~18000
according to a quick google search

Chances of dying from heroin addiction greater than 51%

according to the study found on this page:
www.drugaddictiontreatment.com/types-of-addiction/heroin-types-of-addiction/heroin-addiction-the-long-road-home/
and 43% of the people who didn&#039;t die were still addicted to heroin so only about 25% were able to quit.</description>
		<content:encoded><![CDATA[<p>Pietr, if it stops the heroin from working it is not a punishment. Who&#8217;s talking about forcing them? I&#8217;m sure there are a lot of addicts who would want to take this vaccine if it could stop them from taking heroin.</p>
<p>To Scott and Mountaindog, true it would stop them from being able to receive pain relief from other opiates, but I believe there are alternatives to opiates for pain cessation. I suppose people would have to choose if they want to remain a junkie, kill themselves slowly and live a miserable life or risk that under some uncertain circumstances they could not receive opiate painkillers. I know what I would choose, I would get rid of the pressing problem of being a heroin addict.</p>
<p>Let&#8217;s look at the odds:<br />
Chance of dying in a car accident in your lifetime: 1 in ~18000<br />
according to a quick google search</p>
<p>Chances of dying from heroin addiction greater than 51%</p>
<p>according to the study found on this page:<br />
<a href="http://www.drugaddictiontreatment.com/types-of-addiction/heroin-types-of-addiction/heroin-addiction-the-long-road-home/" rel="nofollow">http://www.drugaddictiontreatment.com/types-of-addiction/heroin-types-of-addiction/heroin-addiction-the-long-road-home/</a><br />
and 43% of the people who didn&#8217;t die were still addicted to heroin so only about 25% were able to quit.</p>
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		<title>By: Pietr Hitzig</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28627</link>
		<dc:creator>Pietr Hitzig</dc:creator>
		<pubDate>Sun, 24 Jul 2011 01:13:30 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28627</guid>
		<description>The goal is not to find rat vaccines against addictive substances but to find realistic treatments for humans.

Humans are far more intelligent than rats. Lust for cocaine and opiates is far more powerful than a simple vaccine. Are we going to tie human beings down and force them to accept substances that will not alleviate their craving?

Philosophers and realists through millennia know that men and women do not respond to the whip but to reward and cessation of pain.</description>
		<content:encoded><![CDATA[<p>The goal is not to find rat vaccines against addictive substances but to find realistic treatments for humans.</p>
<p>Humans are far more intelligent than rats. Lust for cocaine and opiates is far more powerful than a simple vaccine. Are we going to tie human beings down and force them to accept substances that will not alleviate their craving?</p>
<p>Philosophers and realists through millennia know that men and women do not respond to the whip but to reward and cessation of pain.</p>
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		<title>By: Scott Finnell</title>
		<link>http://blogs.discovermagazine.com/80beats/2011/07/23/new-vaccine-curbs-heroin-addiction-in-rats/#comment-28626</link>
		<dc:creator>Scott Finnell</dc:creator>
		<pubDate>Sat, 23 Jul 2011 19:16:48 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/80beats/?p=30630#comment-28626</guid>
		<description>I agree with Mountaindog, I would be very concerned about a drug that lasts a lifetime. What if during that month of blocking the drug, the user has a terrible car accident, and they can&#039;t give them anything for pain? They could die from shock. Also, what about natural opiates that the body produces? would this be blocked  leading to depression and one being in constant pain from a lack of indigenous opiates?</description>
		<content:encoded><![CDATA[<p>I agree with Mountaindog, I would be very concerned about a drug that lasts a lifetime. What if during that month of blocking the drug, the user has a terrible car accident, and they can&#8217;t give them anything for pain? They could die from shock. Also, what about natural opiates that the body produces? would this be blocked  leading to depression and one being in constant pain from a lack of indigenous opiates?</p>
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