Did Parasites Drive Human Evolution?

By Veronique Greenwood | November 16, 2011 12:37 pm

Hookworms are longer-lived than viruses and bacteria;
they could have had a more significant effect on human evolution.

Humans live in all sorts of places—high deserts, tropical lowlands, frigid tundra. Over the millennia, you’d expect each population’s assortment of genes to evolve to reflect the demands and dangers of its home environment: those who live in the deserts would possess genes for extra skin pigments to help keep their tender integument from burning (like African peoples), and those who live in sub-zero climes much of the year would have genes that keep them well-insulated in fat (like the Inuit). But what if factors other than climate, like the food available nearby or the viruses, bacteria, and parasites native to the area, also had an effect on various human populations’ genetic toolkits?

It’s a fascinating question, but, given that we have to reconstruct all this supposed evolution from the current state of modern genomes, finding an answer isn’t easy. A recent paper takes an important first step by looking for correlations between 500,000 different genetic markers and certain environmental characteristics, like humidity, temperature, the local diet, and the prevalence of parasites and other pathogens.

The researchers started out with the genetic information (specifically, their single nucleotide polymorphisms, or SNPs, small differences in the genetic code) of 1,500 people hailing from 55 different populations, including two groups of Bantus, Uygur, and French Basque, and a list of environmental measurements (you can check out their starting data in the three Excel tables here).

Most of the genetic variation between populations turned out be to attributable to drift (the gradual differences that build up between populations that don’t interbreed much), but they did find that some noticeable differences were related to pathogens, food, and climate, with pathogens, parasites especially, having the lion’s share. This suggests that parasites could have driven human evolution, the researchers write, and they opine that this might be because parasites like helminth worms have relatively long life-cycles, so humans had a chance to evolve adaptations to combat them, while short-lived bacteria and viruses might not be causing such strong effects. There are still plenty of gray areas in this realm of population genetics, as outside experts interviewed by Nature News point out: it’s likely that climate, food, and pathogens are closely intertwined as sources of human evolutionary pressure (and furthermore, this study found correlations—not causation). But this paper is an interesting step forward in exploring what forced us to evolve.

Image courtesy of CDC / Wikimedia Commons

  • jasvll

    It was the Gouald, obviously.

  • IW

    You know what this article is missing? A pair o’ cites….

  • Tal

    Sounds a bit trivial to me. our ability to cope with parasites ahould be a major factor in our fitness..

  • http://discovermagazine.com Iain

    “our ability to cope with parasites ahould be a major factor in our fitness.”

    Exactly and those who prospered …

  • John Kwok

    Oh jeezus, not “Stargate SG-1”, please, jasvil. While that may be attractive space opera, what Veronique has written is far more credible than anything Richard Dean Anderson and his castmates could have imagined. It is definitely one that would have mystified Darger and Surplus (A not so subtle hint to those readers who share my enthusiasm for a certain well known pioneering figure of cyberpunk fiction.).

  • toto

    some places where malaria is particularly endemic have a higher population with sickle-cell anaemia, which makes them immune to malaria. O.o


Discover's Newsletter

Sign up to get the latest science news delivered weekly right to your inbox!


80beats is DISCOVER's news aggregator, weaving together the choicest tidbits from the best articles covering the day's most compelling topics.

See More

Collapse bottom bar