Sure, Botox can banish crows feet, smooth those wrinkles, and lift those frown lines, making the client look more youthful–and somewhat expressionless. But the treatment may have effects that are more than skin deep. A new study suggests that by paralyzing the frown muscles that ordinarily are engaged when we feel angry, Botox short-circuits the emotion itself [Newsweek].
In the now-common cosmetic treatment, a doctor injects botulinum toxin, sold under the brand name Botox, under the skin. The toxin kicks in, temporarily paralyzing facial muscles, smoothing skin out, and making a person look less wrinkly as a result. That paralysis, however, seems to interfere with a known feedback loop, in which smiling adds to your happiness and frowning multiplies your sadness [LiveScience]. And tamping down a person’s emotions seems to interfere with the ability to read emotions in others. Says study leader David Havas: “Botox [also] induces a kind of mild, temporary cognitive blindness to information in the world, social information about the emotions of other people” [Discovery News].
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You might not be a smoker yourself, but hanging around people who are smoking can cause you to inhale noxious cigarette fumes. For years, scientists have cautioned against the ill-effects of such second-hand smoke. Now they’re warning about the dangers of “third-hand smoke”—the chemical traces that cling to a smoker, and that are left behind in a room where someone has been smoking.
A team of researchers at the Lawrence Berkeley National Laboratory found that remnants of a smoke don’t just inertly settle onto surfaces, they can react with a common gas (nitrous acid, which is emitted from gas appliances and vehicles, among other sources) to create carcinogenic compounds known as tobacco-specific nitrosamines (TSNAs) [Scientific American]. The study (pdf) was published in Proceedings of the National Academy of Sciences.
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You may have learned of the line of cells known as the HeLa strain in a biology class, where a teacher explained the “virtually immortal” nature of these rapidly multiplying cells, and how they played a defining role in science. Over the last six decades, the prolific HeLa cells have been used to develop the first polio vaccines, test chemotherapy drugs, and develop techniques for in vitro fertilization. With their amazing capacity to multiply, the cells are an endless bounty to scientists. HeLa has helped build thousands of careers, not to mention more than 60,000 scientific studies, with nearly 10 more being published every day, revealing the secrets of everything from aging and cancer to mosquito mating and the cellular effects of working in sewers [The New York Times].
But for all that research, little was known about the origin of the cells or about the unwitting donor who supplied them–Henrietta Lacks (The “He” in HeLa stands for Henrietta and “La,” for Lacks). Lacks was a 30-year old black tobacco worker who died of cervical cancer nearly 60 years ago. She died in a public ward for “coloreds” at the then-segregated Johns Hopkins hospital in Baltimore.
In a new book, The Immortal Life of Henrietta Lacks, author Rebecca Skloot explores Henrietta Lacks’s impoverished background and raises troubling ethical questions. She notes that Lacks’s cells are still used to this day, but the family never received a penny and was largely unaware of the fate of the cells. Over the course of 10 years, Skloot worked with Lacks’s daughter Deborah to uncover the real story behind the HeLa cells.
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There’s your chronological age, the number that creeps depressingly upward with each passing birthday, and then there’s your biological age, associated with the condition of your body. In a study this week in Nature Genetics, a British team discovered a link between a particular genetic variation and people being several years older in their biological age.
Says study leader Nilesh Samani: “What we studied are structures called telomeres which are parts of one’s chromosomes. Individuals are born with telomeres of certain length and in many cells telomeres shorten as the cells divide and age” [Press Association]. Some people, however, are born with shorter telomeres to begin with, which sets them up to age faster, biologically speaking, and could put them at greater risk for age-related diseases.
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As study after study suggests that wine might have health benefits, beer tends to get the short end of the stick. But food scientist and beer lover Charles Bamforth wasn’t going to take that lying down, saying: “The wine guys have stolen the moral high ground. I resent the stance that people take that wine is better. It’s not” [Discovery News]. To prove it, he studied the silicon content of beers from around the country, and in a study in the Journal of the Science of Food and Agriculture, found that beer could be a good source of the substance in your diet.
Bamforth found that the beer’s silicon content ranged from 6.4 milligrams per liter to 56.5 milligrams per liter, with an average of about 30 milligrams. Since two pints of beer are just about equal to one liter, drinking two beers at happy hour could provide 30 milligrams of silicon. And while there is no official recommendation for daily silicon uptake, the researchers say, in the United States, individuals consume between 20 and 50 mg of silicon each day [LiveScience]. Light lagers and non-alcoholic beers not only lack flavor, they showed the lowest silicon content in Bamforth’s study. The ultra-hoppy India pale ales came in first.
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When it comes to a sperm fertilizing an egg, it all comes down to speed and timing. If the sperm starts swimming at top speed too soon, it will die before it reaches the egg. But if it swims too slowly then it won’t get to its destination in time. Now, scientists have discovered a system in the sperm that acts like a gas pedal, causing the sperm to swim faster as it gets closer to the egg. The findings were published in the February issue of Cell.
Researchers already knew that the speed of a sperm depends on its pH, or its internal acidity levels. The less acidic and more alkline it is, the faster it swims. They also knew that a sperm doesn’t sprint at top speed for its entire trip through a woman’s reproductive tract. It travels relatively slowly for the first part of its journey, and then gets lodged in the sticky folds of the fallopian tubes, resting until another, still unknown signal raises their pH again. This initiates their final race to the egg. “It’s a tough job for a sperm — when it’s deposited it has to travel a long distance to the egg sites,” [said Dejian Ren, who was not involved in the new study]. “This process has been known for many decades, but how it actually happens remained a mystery” [The Scientist].
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We’re only a week away from the 2010 Winter Olympics opening in Vancouver, and the return of the games brings with it the return of crazy stories about how far world-class athletes will go to get even the tiniest edge, legal or illegal. In the journal Science this week, researchers led by geneticist Theodore Friedmann take the opportunity to warn about gene doping, the next looming crisis in cheating at high-stakes athletics.
Genetic doping isn’t new to the headlines—the International Olympic Committee banned it in 2003. But its prevalence is growing, especially since improving testing is starting to weed out more standard forms of cheating like steroids and EPO, a hormone that boosts red blood cell production. Three years ago, German track coach Thomas Springstein was busted after unsuccessfully trying to score Repoxygen, an experimental gene therapy drug that boosts red blood cell production, for his runners. At the Olympics in Beijing, an unidentified Chinese doctor offered stem cell injections to a German journalist posing as a swim coach [Wired.com].
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A few months ago, Belgian man Rom Houben hit the headlines for a misdiagnosis that lasted 23 years. Houben was thought to have lost all brain function in a horrific car accident, and was believed to be in a persistent vegetative state. New evaluations helped determine that Houben actually had normal brain activity, and was yearning to communicate–although the “facilitated communication” his family used to allow Houben to tell his story quickly kicked up a kerfuffle over the validity of the whole tale.
Now, a new study published in The New England Journal of Medicine gives credence to the notion that some patients who have been classified as vegetative are actually conscious, and a rare few may be able to communicate.
The researchers used functional magnetic resonance imaging (fMRI) to scan patients’ brains, and to record any activity generated in the patients’ brains following verbal prompts and questions from the doctors. They found signs of awareness in four patients, one of whom was able to answer basic yes or no questions by activating different parts of his brain. Experts said Wednesday that the finding could alter the way some severe head injuries were diagnosed — and could raise troubling ethical questions about whether to consult severely disabled patients on their care [The New York Times].
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Picture the classic shoot-out in a Western movie: The good guy and the bad guy face each other, their hands quivering over their gun holsters. The bad guy reaches for his weapon, causing the good guy to react–he whips out his pistol and BAM! The hero triumphs. Physicist Niels Bohr once had a theory on why the good guy always won shoot-outs in Hollywood westerns. It was simple: the bad guy always drew first. That left the good guy to react unthinkingly – and therefore faster. When Bohr tested his hypothesis with toy pistols and colleagues who drew first, he always won [New Scientist].
But new research suggests that Bohr didn’t have it exactly right. In a study published in Proceedings of the Royal Society B, scientists suggest that people do move faster when they are reacting to what is happening around them–but not fast enough for a heroic gunslinger to save his own life.
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There’s been lots of gloating, arguing, and tossing around of cliches like “game-changing” in the wake of a new study on abstinence education and its potential to reduce sexual activity in teens. But the study isn’t exactly what the political forces trumpeting its arrival would like you to believe.
The study appears in the journal Archives of Pediatrics & Adolescent Medicine. In its introduction, study leader John B. Jemmott III concludes that “Theory-based abstinence-only interventions may have an important role in preventing adolescent sexual involvement.”
So what’s actually in the study? Between 2001 and 2004, Jemmott’s team studied 662 African-American middle schoolers in the northeastern United States, who were each paid $20 a session to attend sex-education classes. The kids were randomly assigned to one of several different programs: One program emphasized only abstinence, one both safe sex and abstinence, one just safe sex, and the last was a control group that simply taught healthy living—eating well, exercise, and the like.
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Today the British medical journal The Lancet, which published the 1998 study by Andrew Wakefield implying autism was linked to vaccinations, fully retracted the study in the wake of increasing allegations of misconduct against the lead author.
The 1998 paper, based on a small sample of 12 children, implied a connection between an autism-like disorder and a triple vaccine for measles, mumps and rubella [AFP]. Despite the small sample size, and a commentary published by The Lancet encouraging caution in interpreting the results, the Wakefield paper became one of the chief sources cited by the modern anti-vaccination movement. His assertion caused one of the biggest medical rows in a generation and led to a big fall in the number of vaccinations, prompting a worrying rise in cases of measles [Reuters].
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As if soccer, wars of incredible length, and the relative worth of wine vs. beer didn’t account for enough disagreements between Britain and France, add another spat to the pile: whether or not the G-spot really exists.
A few weeks ago, a team of scientists from King’s College London joined the ongoing scientific fray by publishing a new study on the much-debated female erogenous zone. It was the biggest to date, involving 1,800 women – all of whom were pairs of identical or non-identical twins. If the G-spot did exist, it said, then genetically identical twins would have been expected to both report having one. However, no such pattern emerged [The Telegraph]. As a result of the study, coauthor Tim Spector said, the study “shows fairly conclusively that the idea of a G-spot is subjective.”
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Cells just keep surprising us. Researchers have now found that, with a little genetic tweaking, they can transform skin cells into brain cells without having to first reprogram them to act like multipurpose stem cells. This finding, the first of its kind, is in this week’s edition of the journal Nature.
The researchers did their study on mice. They induced the change by inserting only three genes into cultured skin cells. Once those three genes activated, the skin cells converted into fully functioning nerve cells that even formed synapse connections with the other converted nerve cells [Popular Science]. That change took less than a week, a surprisingly rapid rate. Said team member Marius Wernig: “These are fully functional neurons. They can do all the principal things that neurons in the brain do” [AFP].
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Perhaps the original design is still the best. In this week’s Nature, Harvard’s Daniel Lieberman and his team reported on the impact force of people who are used to running barefoot versus those of us who wear spongy sneakers to protect the bottoms of our feet. Those who ran barefoot (the way humans evolved to run) moved differently, and with far less stress on their feet than the shoe-wearing masses.
The researchers first traveled to Kenya to watch endurance runners who grew up running sans shoes. The study—the first to test lifelong barefoot runners and not simply people trying it out—found that the barefoot runners landed on the front or middle of their feet. By contrast, runners in shoes typically land on their heels. Lieberman says: “This creates an impact; it’s like someone hitting your heel with a hammer with up to three times your body weight” [BBC News]. In follow-up tests in the United States, the team noted that barefoot runners put, on average, only a third of the initial impact force on their feet than their shod counterparts did.
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For years, prions have been known only as a serious danger to animal and human health. These misfolded brain proteins have been linked to fatal diseases–like mad cow disease in cattle and the deadly variant Creutzfeldt-Jakob disease in humans. But apart from causing these diseases, scientists puzzled for years about the exact function of a properly folded prion protein.
A new study in Nature Neuroscience may have some answers. After 20 years of research, an international team of neuroscientists reports that, in mammals, the mysterious proteins help to maintain the myelin sheath that protects the body’s nerves [Nature News]. A healthy sheath is necessary for nerve cells to transmit impulses rapidly.
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