Tag: connectomics

How to Make a Transparent Mouse with a Few Simple Ingredients

By Veronique Greenwood | August 31, 2011 3:02 pm

embryos
On the left: A mouse embryo preserved in para-formaldehyde. On the right: A mouse embryo soaked in Scale for two weeks.

What’s the News: The trouble with brains, organs, and tissues in general, from a biologist’s perspective, is that they scatter light like nobody’s business. Shine a light into there to start snapping pictures of cells with your microscope, and bam, all those proteins and macromolecules bounce it around and turn everything to static before you’ve gotten more than a millimeter below the surface. Scientists at RIKEN in Japan, however, have just published a special recipe for a substance that makes tissue as transparent as Jell-O, making unprecedentedly deep imaging possible.

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CATEGORIZED UNDER: Mind & Brain
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