They’re about three and a half feet tall and their origins are mysterious, but an isolated group of Ecuadorians with a genetic mutation causing dwarfism are making news for another reason: They hardly ever get cancer or diabetes. Medical researchers say the villagers’ genetic protection from these diseases could lead to preventative treatments for the general population–and could therefore increase human longevity.
The villagers’ condition is called Laron syndrome, which is caused by an insensitivity to growth hormone.
Laron syndrome results from a mutation in the gene that codes for growth hormone receptor (GHR), a protein that binds with the human growth hormone and ultimately results in the production of the insulin-like growth factor 1 (IGF1), causing cells to grow and divide. When a person has two of these mutated and non-working genes, they can develop the disease. [LiveScience]
Jaime Guevara-Aguirre, the leader of the study about the Ecuadorians appearing in Science Translational Medicine, has been looking into their condition and extraordinary resistance to age-related diseases for more than two decades, since his serendipitous discovery of the people while riding horseback in Ecuador.
“I discovered the population in 1987,” Dr. Guevara-Aguirre said in an interview from Ecuador. “In 1994, I noticed these patients were not having cancer, compared with their relatives. People told me they are too few people to make any assumption. People said, ‘You have to wait 10 years,’ so I waited. No one believed me until I got to Valter Longo in 2005.” [The New York Times]
Villagers living in Ecuador’s remote rainforests won a victory in one of the longest-running, most complex environmental lawsuits ever this week. A judge in Ecuador awarded $8.6 billion—with the possibility of another $10 billion or so on top of that—to plaintiffs suing Chevron for polluting the Amazon region during decades of energy exploration. But in a turn of events befitting the tangled web of international environmental law and fights over who should pay for pollution, there’s no guarantee the plaintiffs will actually see that money.
Judge Nicolas Zambrano awarded the $8.6 billion to pay for cleanup and for health care for Ecuadorians made sick by the pollution, plus 10 percent of that total added on top as reparations to the Amazon Defense Coalition. If Chevron doesn’t publicly apologize within 15 days of the ruling—and it isn’t going to—the ruling tacks on another $8.6 billion in punitive damages.
The pollution case itself is full of weird twists and turns. The first thing to know about this mess is that “Chevron” didn’t pollute the region—at least, not under that name.
Chevron does not, in fact, operate in Ecuador today; the American company acquired the lawsuit when it bought Texaco in 2001. Texaco started oil exploration activities with Ecuador’s state oil company Petroecuador back in 1964, and for the next three decades, the 47 plaintiffs say, the company contributed to dumping billions of gallons of waste oil in the region, causing loss of livelihood, widespread health problems and up to 1400 deaths. [TIME]