Family reunion time!

Digging around in your DNA is getting cheaper and easier all the time. For only $207, you can now subscribe to 23andMe’s genotyping service, for instance, which gives you information about your genetic background, potential disease susceptibilities, and other traits. And as the numbers of people in such companies’ databases climb into the hundreds of thousands, it has become possible for software to connect customers who share so much DNA, they may well be relatives. For adoptees who don’t have access to their adoption records and are curious about biological family, there’s never been a better time to go searching. The New York Times follows the story of one 42-year-old woman who, after learning she was adopted,  finds her third cousin through a DNA service, and details the relationship that they form as she deals with the revelation that she is not, after all, the daughter of her adoptive parents.

About five weeks after shipping off two tiny vials of her cells from a swab of her cheek, Mrs. Vaughan received an e-mail informing her that her bloodlines extended to France, Romania and West Africa. She was also given the names and e-mail addresses of a dozen distant cousins. This month, she drove 208 miles from her hometown here to Evansville, Ind., to meet her third cousin, the first relative to respond to her e-mails. Mrs. Vaughan is black and her cousin is white, and they have yet to find their common ancestor. But Mrs. Vaughan says that does not matter.

“Somebody is related to me in this world,” she said. “Somebody out there has my blood. I can look at her and say, ‘This is my family.’ ”

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Artist’s rendering of a mitochondrian, the energy-producing
cellular structure affected by ARSACS

Scientists have pinpointed the cause of a rare, fatal neurodegenerative disorder called ARSACS, or autosomal recessive spastic ataxia of Charlevoix-Saguenay. The disease is due to defects in neuron’s mitochondria, the bit of biological machinery that generates energy for the cell—a structure known to be affected in Parkinson’s, Alzheimer’s, and other neurological diseases, as well.

ARSACS was first observed in the descendants of a small group of 17th century French settlers who made their homes near the Charlevoix and Saguenay rivers in what is now Quebec, and has since been seen worldwide. But its incidence remains unusually high in that particular French Canadian community, with 1 in 1,500 to 2,000 people developing ARSACS and 1 in 23 people unaffected genetic carriers of the disease.

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Because of two missing amino acids, this tomcod can swim through PCBs—and survive.

PCBs are nasty pollutants—they mess with hormones and have been linked to cancer—but until they were banned in 1977, dumping them in US rivers was a common practice for companies like GE. While plenty of wildlife suffered from ingesting PCBs, some fish in the Hudson and other be-sludged rivers evolved an immunity to the poisons, a intriguing example of quick adaptation that scientists have been watching with interest. A recent Economist article focusing on this research describes the fascinating genetic ju-jitsu that allows fish in the Hudson and in the harbor at New Bedford, MA, to keep themselves alive in PCB-contaminated waters. (more…)

Insight into long life is one of the new prize’s goals.

In 2006, the Genomics X Prize competition was announced: $10 million for sequencing 100 human genomes in 10 days for $10,000 apiece, to be kicked off in 2013. The idea was to spur innovation in technology by asking the (currently) impossible, the hallmark of the X Prize Foundation.

But while sequencing has gotten cheap, it hasn’t gotten all that much faster in the last five years, and none of the eight teams who signed up have ever gotten to the point where such a short time span could be feasible. So, Archon and Medco, the two companies funding the competition, have revamped the requirements. This week they’ve announced the new, improved Genomics X prize: $10 million for sequencing 100 human genomes in 30 days—but for $1,000 apiece. (Currently, getting your genome sequenced commercially runs about $5000 at the cheapest.) The new version of the competition, which will kick off on January 3, 2013, also has clearer standards for judging: the genomes have to be 98 percent complete and have no more than one error per million nucleotides.

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Sequencing the DNA in a scoop of dirt can tell scientists what creatures are living nearby, a new study using soil from safari parks shows, and the amount of DNA present can even tell how many individuals of each species there are, which could allow field biologists to get preliminary surveys of species. But though the team managed to identify nearly all the species they had expected in the parks, from wildebeest to elephants, they are still addressing how to take samples that accurately represent the area’s biodiversity—one would have to avoid elephant latrines or wildebeest sleeping areas, for instance—and there is the additional problem that rare or small creatures, like insects, might easily be missed. That said, it’s still an unusual and interesting way to take a look at an area’s inhabitants without actually tracking them down.

Read more at Scientific American.

Image courtesy of malcyzk / flickr

RNAs from rice can survive digestion and make their way into mammalian tissues, where they change the expression of genes.

What’s the News: It’s no secret that having lunch messes with your biochemistry. Once that sandwich hits your stomach, genes related to digestion have been activated and are causing the production of the many molecules that help break food down. But a new study suggests that the connection between your food’s biochemistry and your own may be more intimate than we thought. Tiny RNAs usually found in plants have been discovered circulating in blood, and animal studies indicate that they are directly manipulating the expression of genes.

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Children of older mothers, scientists have long known, are at higher risk for certain genetic disorders such as Down syndrome. But the father’s age is matters, too. As a father’s age increases, research shows, so does his child’s risk of mental illness, schizophrenia and autism in particular. In Scientific American, Nicole Grey explores the link between a father’s age and his child’s health, as well as the tricky questions about what mechanisms are behind the that link: genes, epigenetic changes, environment, or some combination of the three.

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What’s the News: Whether genes can be property is an ongoing controversy in the world of biotechnology, and last week saw the latest court battle in that war: Upon appeal, a suit brought by the ACLU charging that genes aren’t products of human ingenuity and thus cannot be patented was settled largely in favor of Myriad Genetics, the biotech company that has patents on two BRCA genes. The genes are linked to hereditary breast and ovarian cancer, and plaintiffs charged that Myriad’s exclusive test for the genes kept patients from getting second opinions.

A detailed description of the court’s reasoning can be found over at Ars Technica. But for those of you who are thinking, what? someone else can own my genes?, chew on this: About 20% of human genes are patented or have patents associated with them, according to a comprehensive analysis. Here’s why.

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What’s the News: What if the egg is fine and the sperm is dandy, but you still can’t seem to have a baby? Couples who are having trouble conceiving can testify to the frustration of learning that there’s no clear reason for their infertility. Now, however, scientists have found a genetic mutation that makes outwardly normal sperm much less fertile, potentially explaining many such cases and suggesting new routes to conception.

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What’s the News: By knocking out a single gene, scientists at the University of Pennsylvania have significantly increased the physical endurance of lab mice, as explained in their recent paper in the Journal of Clinical Investigation. The researchers also found that certain variants of the same gene may be linked to greater endurance in humans.

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What’s the News: Scientists have been rooting around in the rice genome for years, and the same goes for wheat. But now the long-recalcitrant potato genome has finally been sequenced. Time for a celebration? Perhaps, but biologists can’t rest for long: in addition to the just-published genome, there are still three more to sequence in each commercial potato.

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What’s the News: When personal genotyping service 23andMe was founded in 2006, most people were understandably focused on the benefits and the dangers of knowing your chances of getting an incurable disease. But a major part of the company’s business plan was eventually leveraging their users’ information to explore the genetic basis of disease.

With more than 100,000 people now in their database, 23andMe has been turning that into a reality. They’ve just published their first paper focusing on the origins of disease, pinpointing two new areas of the genome involved in Parkinson’s.

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What’s the News: While you may be able to hide your age with makeup and plastic surgery, don’t think that your deception is foolproof. Researchers have now developed a technique to ascertain your age to within five years using only your saliva. The new method, published in the journal PLoS One, could someday be used by forensic experts to pinpoint the age of crime suspects.

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Could Neanderthal DNA have protected our ancestors from diseases?

What’s the News: While we humans have certainly outlasted our hominin cousins, new research shows that Neanderthal and Denisovan genes may have helped us spread far and wide. By mating with the two species, our ancestors acquired genes that allowed them to adapt to diseases outside of Africa far quicker than would have been otherwise possible, according to Peter Parham, a professor of microbiology and immunology at Stanford University.

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