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A controversial proposal to switch the U.K.’s current system of voluntary organ donation to a system of “presumed consent” was rejected by the UK Organ Donation Taskforce, which said the change would not increase organ donations and could damage patient-doctor as well as donor-recipient relations. Presumed consent would designate everyone as an organ donor unless the individual or the family of the deceased opted out; the current system is just the opposite, harvesting organs only from people who opt in to organ donation.

The task force advised against the switch supported by Prime Minister Gordon Brown, the British Medical Association (BMA), and several physician groups. Nevertheless, Brown continues to support a presumed consent system. “While they are not recommending the introduction of a presumed consent system, as I have done, I am not ruling out a further change in the law,” he said [The Guardian].

The U.K. has one of Europe’s lowest rates of organ donation. Of an estimated 8,000 people on waiting lists for organ transplants, only about 3,000 receive transplants every year, and 1,000 die while waiting for a transplant. Vivienne Nathanson, the BMA’s Head of Science and Ethics, said presumed consent was not a panacea, but was likely to result in a 10 to 15 per cent increase in donated organs, if sufficient surgeons, intensive care beds and transplant coordinators were put in place. She said it would also encourage families to discuss their views, and make their wishes clear before death: “We know that the majority of the population want to be organ donors, but only 25 per cent are on the register” [Times Online].

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The European Commission has proposed a ban on medical research performed on our species’ closest relatives, the great apes. The pan-European initiative would extend a ban already in force in Austria, Great Britain, the Netherlands, and Sweden across the entire 27-member bloc. The ban, however, would not greatly affect current research, because no testing has been carried out on great apes in the EU for the past six years [The Scientist]. Nevertheless, the proposal [pdf] has received mixed reviews from both the scientific community, who fear excessive red tape, and animal rights groups, who say the ban does not go far enough.

If approved, the ban would prohibit researchers from using great apes, including chimpanzees, bonobos, gorillas, and orangutans, to test scientific “procedures,” although behavioral studies will still be allowed. There will also be exceptions for research that could save a great ape species threatened with extinction and in the case of a serious pandemic that affects humans. The proposal also affects research on other animals, stressing the “3Rs” of reducing the number of animals used, refining techniques to lessen pain and discomfort, and replacing animal studies with alternatives [ScienceNOW Daily News]. Some 12 million vertebrate animals are used each year in experiments throughout the 27-nation bloc — half for drug development and testing, a third for biology studies and the rest for cosmetics tests, toxicology and disease diagnosis [Reuters].

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About half of surveyed U.S. doctors say they regularly prescribe placebos without their patients knowledge, and most admit to no qualms about handing out vitamins, aspirin, and other benign pills that have little relevance to the symptoms their patients complain of, according to a new study. Several medical ethicists say they’re troubled by the results, including study coauthor Franklin Miller: “This is the doctor-patient relationship, and our expectations about being truthful about what’s going on and about getting informed consent should give us pause about deception” [The New York Times].

Study coauthor John Tilburt says these findings are a reflection of the modern mentality that for every symptom you may experience, there’s a pill to make it all better…. “Doctors feel pressured to prescribe something in order to show the patient that they are taking their symptoms seriously and trying to do something about it, so they try to find creative ways to make patients feel better, and will use any tool available, including psychological benefits” [ABC News].

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Ten intrepid genetic explorers have volunteered to have their genetic information posted on the Internet for anyone’s perusal, along with photographs, their disease histories, allergies, medications, ethnic backgrounds and a trove of other traits, called phenotypes, from food preferences to television viewing habits [The New York Times]. The 10 volunteers are the first participants in the Personal Genomics Project, an endeavor run by Harvard Medical School that hopes to offer free genetic testing to 100,000 people in exchange for their privacy.

The project aims to advance genome research by tapping volunteers who have a Facebook-mentality sense of privacy–minimal–and enough excitement about genomic science that they are willing to lay out their genetic and medical information so any researcher can sift through it for links between genes and traits. “There’s a hope that by making these data public, you can harness crowd-sourcing power in the same way that Wikipedia and YouTube and Google and Linux all emerged from cooperative, distributed efforts” [Boston Globe], said Harvard psychology professor Steven Pinker, who is one of the 10 pioneers.

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This week, South African health minister Barbara Hogan got her country up to speed with the rest of the world with one statement: “We know that HIV causes AIDS” [Time]. The country’s new health minister has been in office for less than a month, but she has already broken with the health policies of the previous government, which questioned the scientific consensus on HIV and AIDS, and discouraged the use of life-saving AIDS drugs.

Her pronouncement at an international AIDS vaccine conference marked the official end to 10 years of denial about the link between HIV and AIDS by former President Thabo Mbeki and his health minister Manto Tshabalala-Msimang. Activists also accused Tshabalala-Msimang of spreading confusion about AIDS through her public mistrust of antiretroviral medicines and promotion of nutritional remedies such as garlic, beetroot, lemon, olive oil and the African potato [AP]. Tshabalala-Msimang earned the nickname “Dr. Beetroot” from frustrated activists for her recommendations.

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New health concerns have been raised about the plastic chemical bisphenol A (BPA); a study suggests that there is a link between high levels of exposure to BPA and an increased risk of heart disease and diabetes. While the new study doesn’t prove a cause and effect relationship, only a correlation, it is the first human survey to follow up on troubling findings from animal studies.

The chemical, which is often found in baby bottles, sports water bottles, and other non-recyclable containers, has gotten several waves of bad press in the past few months. A recent experiment showed that extremely high doses of the chemical damage monkeys’ brains, and other work in animals has suggested that BPA has the potential to disrupt normal hormone signalling by mimicking the natural hormone, oestrogen. Such studies have linked the chemical to a wide range of conditions, including low sperm count, altered fetal development, behavioural disorders in children and prostate cancer [Nature News].

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Meat and milk from the offspring of cloned animals may already be part of the U.S. food supply, the Food and Drug Administration announced this week. While the cloning process is too expensive (about $20,000 per animal) to justify creating clones that will be turned into hamburgers, some ranchers have cloned animals with desirable traits, which they then breed the old-fashioned way to create offspring. Officials said it is impossible to differentiate between cloned animals, their offspring and conventionally bred animals, making it difficult to know if offspring are in the food supply [Reuters].

The use of cloned livestock–particularly cows, swine, and sheep–has been fiercely debated in the United States and Europe. In January, the FDA declared that cloned animals and their offspring were as safe to eat as conventionally bred animals; regulators still ask that food companies follow a voluntary moratorium on using cloned animals for food production, but no such moratorium exists for the clones’ natural offspring. Those offspring may have made it into the food supply, a U.S. Agriculture Department spokesman said, but “they would be a very limited number because of the very few number of clones that are out there and relatively few of those clones are at an age where they would be parenting” [Reuters].

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A new study of a chemical commonly used in plastic containers found that it causes damage to monkey’s brains, raising new concerns over the chemical’s possible effects on humans. The chemical, called bisphenol A or BPA, has been the source of controversy for months as government agencies and scientists have gone back and forth on whether the substance is a health threat. BPA has been in commercial use since the 1950s, and is found in baby bottles, water bottles, in the lining used for canned goods, and many other items.

In the latest study, the research team exposed monkeys to levels of bisphenol A deemed safe for humans by the Environmental Protection Agency and found that the chemical interfered with brain cell connections vital to memory, learning and mood. “Our findings suggest that exposure to low-dose BPA may have widespread effects on brain structure and function,” the authors wrote [Washington Post].

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A new method to identify an individual’s genetic profile from a larger pool of genetic data could be a boon for forensic science, but is causing headaches for the National Institutes of Health. In response to a study describing the technique, the NIH quickly removed several publicly available databases of DNA information drawn from medical studies, citing concerns that patients’ privacy could be threatened.

The new type of DNA analysis could only identify an individual if that person’s genetic profile was already known. Such a confirmation could reveal patients’ participation in a study about a specific medical condition, denying them their presumed confidentiality, experts said [Los Angeles Times]. NIH officials say they took down the databases, which contained genetic data from more than 60,000 patients, as a precautionary measure, and say it’s unlikely that the privacy of any of those patients has been violated.

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The Food and Drug Administration released a draft report on Friday saying that a chemical used in baby bottles and other plastics is not a health threat. The FDA announcement is just the latest twist to a health story that has already alarmed and confused consumers; the chemical, called bisphenol A or BPA, was recently declared a toxin by the Canadian government, and several states are considering banning products that contain it. In April, Wal-Mart announced that its stores will stop selling baby bottles containing BPA.

BPA, a plastic-hardening chemical, is similar to the hormone estrogen. A report in April from the U.S. National Toxicology Program said animal studies suggested its use may pose a cancer risk and lead to early or delayed puberty [Bloomberg]. But the new FDA report says that only small amounts of the chemical leach out from bottles and the lining used for canned foods, and says that it doesn’t pose a threat to infants or adults.

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In a controversial new procedure, doctors removed the hearts from three severely brain damaged infants soon after the babies were removed from life support and transplanted the organs to three other infants, where the hearts were restarted. The news is raising complicated questions about when a patient can be declared dead, and whether doctors are pushing an already controversial organ-retrieval strategy beyond acceptable legal, moral and ethical bounds [The Washington Post].

The hearts of the three donor babies stopped beating soon after their ventilators were removed. In the first case, the Denver team waited three minutes after what appeared to be the last heartbeat. But because there has never been a case where the heart restarted itself after 60 seconds, they waited only 75 seconds for their next two cases [Reuters]. All three babies who received new hearts would have died without the transplants; six months after the operations, all three were doing fine. Doctors believe the swift organ removals from the donor babies increased the odds of survival for the recipient babies.

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At the age of 75, men should stop getting screened for prostate cancer, according to new recommendations from a government task force. The group reported finding evidence that the benefits of treatment based on routine screening of this age group “are small to none” [AP]. Those potential benefits are far outweighed by the possible anxiety, unnecessary surgery, and harmful side effects that elderly men can experience if the screening finds early-stage prostate cancer and the patient chooses to treat it.

Most oncologists already argue against treating most men in that age group for prostate cancer because they are more likely to die from some other cause than from their tumor [Los Angeles Times]. Prostate cancer often progresses slowly, and doctors say it can take 10 years before a patient begins to show symptoms. Many doctors now advocate a “watchful waiting” approach when prostate cancer is detected, instead of aggressive treatment that can cause impotence, incontinence, and bowel problems.

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Last week’s suicide by a government biodefense researcher who had been linked to the mailing of anthrax-laced letters in 2001 has raised thorny questions about whether the benefits of biodefense research outweigh the risks. Researcher Bruce Ivins had reportedly been informed by the FBI that he was about to be indicted for murder in the incident that killed five people and sent 17 more to the hospital.

Some observers point out that biodefense research has vastly increased since the terrorist attacks of 2001, and raise the question: Has the unprecedented boom in biodefense research made the country less secure by multiplying the places and people with access to dangerous germs? … Nationwide, an estimated 14,000 people work at about 400 laboratories and have permission to work with so-called select agents, which could be used in a bioterror attack, although not all are authorized to handle the most toxic substances, like anthrax [The New York Times].

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California is striking a blow against obesity and heart disease: On Friday, Governor Arnold Schwarzenegger signed a bill outlawing the use of trans fats in all restaurants and bakeries. The bill creates the first state-wide ban of trans fats, but follows the path set out by cities like New York City and Philadelphia, which have already evicted the substance from restaurants within city limits.

Trans fats are created by pumping hydrogen into liquid oil at high temperature, a process called partial hydrogenation. The process results in an inexpensive fat that prolongs the shelf life and appearance of packaged foods and that, many fast-food restaurants say, helps make cooked food crisp and flavorful [The New York Times]. The artificial fats have been shown to increase levels of “bad” cholesterol and decrease levels of “good” cholesterol, and are therefore linked to heart disease.

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A report from an European Union agency says that while meat and milk from cloned animals appears to be safe for human consumption, more studies are needed to prove the point. While the document from the European Food Safety Authority is not the final word on the matter, it seems to indicate that European consumers won’t be chowing down on steaks from cloned cows anytime soon.

“For cattle and pigs, food safety concerns are considered unlikely. But we must acknowledge that the evidence base is still small. We would like to have a broader data base and we need further clarification” [Reuters], said an agency official. The report also said that cloning has a negative impact on the health and welfare of the animals, as clones are more likely to be born with birth defects and often die younger.

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