Although the spinal cord can recover from minor damage, severe injuries, like those that cause paralysis, are permanent…right? When deep cuts partially sever rats’ spinal cords, they isolate the lower part of the spine from the brain. Since that part of the spine is responsible for controlling the rats’ hind limbs, it leaves the legs paralyzed. A team of Swiss scientists tackled the challenge of restoring the brain-to-limb connection, successfully re-teaching paraplegic rats to walk, run, and climb stairs.
First, the researchers injected the isolated section of spinal cord with neuron-exciting chemicals called neurotransmitters. Then, they used electrodes on the outside of the spinal cord to send continuous electrical signals to those excited nerve cells. This chemical and electrical stimulation acted as a sort of molecular prosthesis for the signals that would normally come from the brain but that couldn’t get past the spinal injury.
A recent column by Dr. Pauline Chen at the New York Times explores a surprising oversight in modern healthcare: Doctors don’t really have a clue how to predict how long a patient will live. In the absence of a widely accepted, systematic method of prognosis, they’re kind of making it up—an informed guess, with the benefit of education and experience, but a guess nonetheless.
Prognosis was once a diligently studied, widely practiced part of a physician’s job, Chen writes. But as treatments improved, and keeping patients alive longer became ever more possible, the unpleasant but necessary skill of predicting when patients might die fell by the wayside. A recent study, she reports, revealed just how much:
What’s the News: As human societies adopted agriculture, their people became shorter and less healthy, according to a new review of studies focused on the health impacts of early farming. Societies around the world—in Britain and Bahrain, Thailand and Tennessee—experienced this trend regardless of when they started farming or what stapled crops they farmed, the researchers found.
This finding runs contrary to the idea that a stable source of food makes people grow bigger and healthier. The data suggest, in fact, that poor nutrition, increased disease, and other problems that plagued early farming peoples more than their hunter-gatherer predecessors outweighed any benefits from stability.
What’s the News: Scientists have identified three gene mutations that lead to acute myeloid leukemia, a cancer that afflicts white blood cells, which may lead to better cancer drugs in the future. As Wellcome Trust Sanger Institute hematologist George Vassiliou told the BBC, his team’s study “found critical steps that take place when the cancer develops. Identifying the biological steps … means we can look for new drugs to reverse the process.”
How the Heck:
What’s the Context:
Not So Fast: Researchers caution that it could take decades before new cancer-fighting drugs based on this study come on the market. This present study only used mice as subjects.
Reference: George S Vassiliou et al. “Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.” Nature Genetics. doi:10.1038/ng.796
Image: Wikimedia Commons / Bruce Wetzel