In the presence of ultraviolet light, the nanoparticle
shrinks from 150 to 40 nanometers.
As anyone who has played with a powerful laser or just suffered a bad sunburn can attest, light has an impressive power to physically change objects. And now we know that light can make nanoparticles expand and contract like miniature Hoberman Spheres. MIT and Harvard researchers engineered nanoparticles that shrink to less than a third of their original size when exposed to ultraviolet rays; in the darkness or under visible light, they open back up to their more stable, larger size.
Nanoparticles have been touted as an effective way to deliver cancer-killing drugs straight to tumors without harming healthy cells in the process. But the structure of a tumor can block all but the smallest particles—those less than 100 nanometers (billionths of a meter)—from penetrating to the cancer’s heart. To deliver drugs to the entire tumor, the researchers suggest that the particles could be deployed while UV light keeps them in their smaller form, about 40 nanometers. Then, when the UV light is switched off, the particles will open to their full 150-nanometer size and release the drugs.