Two American men and an Israeli woman have won the Nobel Prize for chemistry for work that probed the structure of the ribosome, the cell’s protein factory. Venkatraman Ramakrishnan, Thomas Steitz, and Ada Yonath worked separately to understand one of life’s core processes: the method by which ribosomes translate genetic code into proteins, the building blocks of all organisms.
Their work revealed what ribosomes, which produce proteins that control the chemistry in all living organisms, look like and how they function at the atomic level. The Laureates also created three-dimensional models that show how different antibiotics bind to the ribosome, research that has been used to develop new anti-infective medicines [Bloomberg].
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Three scientists who mastered light through technology have been awarded this year’s Nobel Prize for physics, for breakthroughs that the prize committee said “helped to shape the foundations of today’s networked societies.” Half of the $1.4 million prize goes to Charles Kao (pictured), for his work on fiber optics, while the other half will be divided between Willard Boyle and George Smith, two retired researchers from Bell Labs who invented the first imaging technology using a digital sensor instead of film, paving the way for the creation of digital cameras.
Kao’s discovery in fiber optics set the stage for the technological revolution that underpins today’s global communication systems, powering broadband internet connections and carrying data transmissions around the world. In 1966, he figured out how to transmit light for more than 100 kilometers using optical glass fibers, five times the length of the most advanced fibers then available [Bloomberg]. Fiber optics have become ubiquitous in today’s wired, networked world; the Nobel committee noted that if all the optical cables in use today were unraveled, it would equal a single thread more than a billion kilometers long, enough to circle the globe 25,000 times.
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The Nobel Prize for medicine has been awarded to three U.S. researchers who probed the mechanism of cellular division, and whose work opened new avenues both in the fight against cancer and attempts to slow aging. The prize will be shared by Australia-born Elizabeth Blackburn, Carol Greider, and London-born Jack Szostak.
The three researchers solved the mystery of how chromosomes, the rod-like structures that carry DNA, protect themselves from degrading when cells divide. The Nobel citation said the laureates found the solution in the ends of the chromosomes — features called telomeres that are often compared to the plastic tips at the end of shoe laces that keep those laces from unraveling [AP].
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Experiments conducted on squid brains in the early days of neuroscience created misunderstandings about the workings of the human brain that have persisted for 70 years, according to a new study. While the squid experiments did shed light on how messages are transmitted between brain cells with electrochemical signals (and led to a Nobel Prize for the experimenters), researchers are just now realizing that the results gave scientists a confused idea about the efficiency of neurons.
The story begins seventy years ago when a pair of British physiologists, Alan Hodgkin and Andrew Huxley, took the first stab at figuring out how neurons transmit electrical signals, known as action potentials. Because most neurons are small–in humans, a cubic millimeter of gray matter can contain 40,000 neurons–the duo turned to squid, which contain a giant axon, the long thin part of a neuron through which action potentials travel [ScienceNOW Daily News]. Those early experiments found that transmitting the action potential along the axon was a very inefficient process that used a great deal of energy, and neuroscientists ever since have assumed that mammal brains had the same inefficient wiring.
Researcher Henrik Alle, lead author of the new study published in Science, decided to reexamine the old assumptions. “I saw this old work,” says Alle. “I thought I cannot believe personally that nature would waste such energy.” Alle figured that nature would have made the process more efficient in mammals, whose brains send a huge number of messages [NPR News].
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Norman E. Borlaug, a world-renowned American botanist, died this past Saturday at his home in Dallas from complications due to cancer. Borlaug, who was 95, won the Nobel Peace Prize in 1970 for starting the “Green Revolution” that dramatically increased food production in developing nations and saved countless people from starvation [Washington Post]. Borlaug pioneered high-yield agricultural techniques, using cross-bred crops and nitrogen fertilizers, which helped India, Mexico, and other nations combat hunger and become self-sufficient producers of grains.
“Civilization as it is known today could not have evolved, nor can it survive, without an adequate food supply,” said Borlaug during his Nobel Lecture in 1970. “Yet food is something that is taken for granted by most world leaders despite the fact that more than half of the population of the world is hungry. Man seems to insist on ignoring the lessons available from history.”
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Trying to assess the importance of particular scientific papers has long been a tricky task. The current system relies on counting the number of times a paper is cited by others to determine how large an effect it has had on subsequent research, but this number can be misleading, a new study notes. Simply counting citations favors disciplines such as biology, where papers tend to be cited more, over fields such as mathematics, where citations are less frequent. In addition, a citation from a relatively marginal paper counts just the same as a citation from a leading researcher publishing in a marquee journal [Scientific American].
To try to get around these problems, a pair of researchers decided on a different tactic: They took the algorithm that Google uses to determine how to rank the Web pages turned up in a search result, and used it to rank the importance of scientific articles. The Google PageRank algorithm checks the number of times each Web page is linked to in order to determine its importance, which is equivalent to counting citations. But it has several other aspects that were very useful when applied to ranking scientific papers. The algorithm gives greater weight to citations from papers that list only a few references, and also to citations from papers that are themselves often cited. “Because of these attributes, PageRank readily identifies a large number of scientific ‘gems’–modestly cited articles that contain ground-breaking results” [arXiv], the researchers write. Among those gems turned up in the researchers first experiment were nine papers written by future Nobel Prize winners.
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President-elect Barack Obama has thrilled the scientific community with the leaked news that he plans to nominate a Nobel Prize-winning physicist with a passion for green technology for the post of energy secretary. The likely nominee, Steven Chu, currently heads the Lawrence Berkeley National Laboratory, and shared the Nobel in physics in 1997 for developing a method to cool and trap atoms.
Recently, however, Chu’s interests have shifted away from particle physics and towards finding scientific solutions for global warming. In an interview last year, Chu said he began to turn his attention to energy and climate change several years ago. “I was following it just as a citizen and getting increasingly alarmed,” he said. “Many of our best basic scientists [now] realize that this is getting down to a crisis situation” [Washington Post]. Since he became director of Lawrence Berkeley Lab in 2004 he has focused on making it a world leader in alternative energy research, spearheading research initiatives on solar energy and biofuels.
Obama is also expected to nominate Carol Browner, the EPA administrator under President Clinton, as the top White House official on climate and energy policy, and Lisa Jackson, who was until recently was New Jersey’s environmental protection chief, to head the EPA. Along with Chu, these people will be at the center of Obama administration’s energy and environment policy, which aims to reduce greenhouse gas emissions growth and have energy efficiency play an important role in an expected economic stimulus package [CNET].
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Three researchers who worked on a fluorescent protein found in jellyfish and developed it into a standard laboratory tool have been awarded the Nobel Prize in chemistry, the prize committee announced today. The three researchers, Osamu Shimomura, Martin Chalfie, and Roger Tsien, worked separately to first isolate the protein, which glows brightly when exposed to ultraviolet light, and then to develop ways to use it as a luminescent marker in the cells of other organisms.
Said the prize committee: “The remarkable brightly glowing green fluorescent protein, GFP, was first observed in the beautiful jellyfish, Aequorea victoria in 1962…. Since then, this protein has become one of the most important tools used in contemporary bioscience. With the aid of GFP, researchers have developed ways to watch processes that were previously invisible, such as the development of nerve cells in the brain or how cancer cells spread” [Reuters].
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Three scientists who probed the mysteries of particle physics have been awarded the Nobel Prize in physics, the Royal Swedish Academy of Sciences announced today. The winners are Yoichiro Nambu, a Tokyo-born American citizen, and Makoto Kobayashi and Toshihide Maskawa of Japan. Nambu identified a mechanism called spontaneous broken symmetry in subatomic physics. Kobayashi and Maskawa work predicted the existence of three families of elementary particles known as quarks. According to the Standard Model of particle physics, quarks are the sub-units of protons and neutrons, which together make up the nuclei of atoms [BBC News].
“Spontaneous broken symmetry conceals nature’s order under an apparently jumbled surface,” the academy said in its citation. “Nambu’s theories permeate the standard model of elementary particle physics. The model unifies the smallest building blocks of all matter and three of nature’s four forces in one single theory.” Kobayashi and Maskawa “explained broken symmetry within the framework of the standard model but required that the model be extended to three families of quarks” [AP].
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Three researchers who discovered viruses that cause serious diseases have been awarded the Nobel Prize in medicine, the Nobel Foundation announced today. The prize was awarded jointly to France’s Francoise Barre-Sinoussi and Luc Montagnier, who worked together to identify the HIV virus that causes AIDS, and also to the German scientist Harald zur Hausen who discovered the human papilloma viruses (HPV) that can cause cervical cancer.
Barre-Sinoussi, who is the eighth woman to win the medicine prize since the first Nobel Prizes were handed out in 1901, worked with Montagnier to discover the HIV virus. Shortly after reports in the early 1980s of a new immunodeficiency syndrome, researchers all over the world raced to find the cause. The two [researchers] cultured cells from lymph nodes of patients. They first detected the enzyme reverse transcriptase, which meant that a retrovirus was active. Further searching turned up retroviral particles, which could kill white blood cells and which also reacted with antibodies from infected patients [Scientific American].
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