Blogs / 80beats

In the first major doping scandal of the Beijing Olympics, a North Korean pistol shooter has been stripped of his silver and bronze medals after testing positive for the drug propranolol. The drug, which belongs to a class called beta-blockers, would not be considered a performance-enhancing drug in most sports; it works by blocking the action of adrenaline, and therefore lowers blood pressure and heart rate.

Cardiologist Sandeep Jauhar explains that while propranolol is used to treat high blood pressure, it has additional uses: “It’s also used to treat other conditions that are mediated by high adrenaline levels, such as tremor and performance anxiety. Beta blockers don’t lower the anxiety level, but they lower manifestations of the anxiety, such as fast heart rate, sweating, and tremor” [Scientific American]. Anti-doping officials from the International Olympic Committee (IOC) believe that the shooter, Kim Jong Su, used the drug to keep his hands from shaking during the competition.

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Researchers have developed two drugs that mimic some of the effects of exercise in mice, leading to rampant speculation that people may soon be able to take a dose of “exercise in a pill.” The dramatic study showed that the drugs built fat-burning muscles in mice and increased their endurance on an exercise wheel. Four years ago researchers bred genetically engineered mice that could run much further than normal, but this is the first test to prove that drugs can have the same effect [Telegraph].

“It’s tricking the muscle into ‘believing’ it’s been exercised daily,” said the study’s lead researcher, Ronald Evans…. “It’s basically the couch potato experiment, and it proves you can have a pharmacologic equivalent to exercise” [Wired News]. One drug proved effective for mice that were already exercising regularly, increasing their running time by 68 percent and distance by 70 percent. The other drug worked on mice that hadn’t been trained to exercise; that compound increased their running time by 23 percent and distance by 44 percent.

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Despite the International Olympic Committee’s vow to vigilantly test for performance enhancing drugs at the Summer Olympics in Beijing, some scientists and sports doctors say that athletes are likely to cheat at the games, and get away with it.

The focus is on erythropoietin (EPO), a hormone naturally produced by the kidneys which regulates red blood cell production. When extra EPO is injected before a competition, it boosts performance by increasing the amount of red blood cells in an athlete’s body; those blood cells then carry more oxygen to the hard-working muscles.

Anti-doping agencies regularly test athletes for EPO, but some researchers say the agencies can’t develop tests fast enough to keep up with new “copycat” versions of EPO, often produced by pharmaceutical companies in India, Cuba, and China. These cheap versions of EPO, often called biosimilars, can be easily bought over the internet…. Some scientists who track and monitor the development of copycat EPO drugs say there could be up to 80 different versions now being manufactured in different parts of the world [BBC News].

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