Tag: personal genomics

Discovering Long-Lost Relatives Through Commercial DNA Tests

By Veronique Greenwood | January 24, 2012 12:16 pm

Family reunion time!

Digging around in your DNA is getting cheaper and easier all the time. For only $207, you can now subscribe to 23andMe’s genotyping service, for instance, which gives you information about your genetic background, potential disease susceptibilities, and other traits. And as the numbers of people in such companies’ databases climb into the hundreds of thousands, it has become possible for software to connect customers who share so much DNA, they may well be relatives. For adoptees who don’t have access to their adoption records and are curious about biological family, there’s never been a better time to go searching. The New York Times follows the story of one 42-year-old woman who, after learning she was adopted,  finds her third cousin through a DNA service, and details the relationship that they form as she deals with the revelation that she is not, after all, the daughter of her adoptive parents.

About five weeks after shipping off two tiny vials of her cells from a swab of her cheek, Mrs. Vaughan received an e-mail informing her that her bloodlines extended to France, Romania and West Africa. She was also given the names and e-mail addresses of a dozen distant cousins. This month, she drove 208 miles from her hometown here to Evansville, Ind., to meet her third cousin, the first relative to respond to her e-mails. Mrs. Vaughan is black and her cousin is white, and they have yet to find their common ancestor. But Mrs. Vaughan says that does not matter.

“Somebody is related to me in this world,” she said. “Somebody out there has my blood. I can look at her and say, ‘This is my family.’ ”

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CATEGORIZED UNDER: Health & Medicine

To Boost Database Diversity, 23andMe Offers Free Genome Tests to 10,000 African Americans

By Veronique Greenwood | August 8, 2011 1:23 pm


When people talk about how genetics testing is paving the way for personalized medicine, there’s a subtext that’s not always made clear: that’s personalized medicine for Northern Europeans and their descendants. Non-whites are hugely underrepresented in most collections of genomes, which means if you’re Asian or African, it’s hard to say what genetic predispositions you might have to certain diseases, or how you will react to drugs that target certain forms of enzymes, for example.

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23andMe Kicks Its Genomic Research into Gear with Parkinson's Study

By Veronique Greenwood | June 29, 2011 9:20 am


What’s the News: When personal genotyping service 23andMe was founded in 2006, most people were understandably focused on the benefits and the dangers of knowing your chances of getting an incurable disease. But a major part of the company’s business plan was eventually leveraging their users’ information to explore the genetic basis of disease.

With more than 100,000 people now in their database, 23andMe has been turning that into a reality. They’ve just published their first paper focusing on the origins of disease, pinpointing two new areas of the genome involved in Parkinson’s.

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CATEGORIZED UNDER: Health & Medicine

UC Berkeley Halts Its Freshman DNA Testing Project

By Andrew Moseman | August 13, 2010 2:55 pm

UCBerkeleyIs it medicine, or is it not?

In May, the University of California, Berkeley unveiled its “Bring Your Genes To Cal” program. The idea was, Berkeley’s 5,500 or so incoming freshman would have the option to have their DNA tested for three particular characteristics: Their metabolism of folate, tolerance of lactose, and metabolism of alcohol. Though the program was limited, it raised privacy hackles. And now the State of California has ruled: This is a medical test, and Cal can’t do it unless it’s in a clinical setting.

Mark Schlissel, UC Berkeley’s dean of biological sciences and an architect of the DNA program, said he disagreed with the state Department of Public Health’s ruling that the genetic testing required advance approval from physicians and should be done only by specially-licensed clinical labs, not by university technicians. The campus could not find labs willing to do the work and probably could not afford it anyway, Schlissel said. He also contended that the project deserved an exemption from those rules because it was an educational exercise [Los Angeles Times].

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Government Sting Operation Finds Problems With Personal Genetics Tests

By Andrew Moseman | July 23, 2010 10:31 am

23andmeThe summer of our government’s discontent (with personal genetics tests) continues. Yesterday an investigator with the Government Accountability Office reported back to Congress on its undercover investigation of the tests on the market, saying that testing the DNA of GAO staffers returned frequently contradictory and confusing answers.

“Consumers need to know that today, genetic testing for certain diseases appears to be more of an art than a science,” said GAO investigator Gregory Kutz [CBS News].

Here at 80beats, we’ve gone over some of the potential problems with these tests. DISCOVER blogger Ed Yong covers them in great detail in a post he wrote this week after getting his genes tested by 23andMe, including the dearth of data appropriate for interpreting results if you’re of Asian rather than European descent, and deciding whether to peek into the data that says whether you have a much higher than average risk for Parkinson’s disease.

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FDA: We're Going to Regulate Those Personal Genetics Tests, After All

By Andrew Moseman | June 14, 2010 11:56 am

23andmeThe Food and Drug Administration has a message for the personal genomics revolution: slow down.

Personal DNA tests have been available for years now from companies like 23andMe and Pathway Genomics, and the direct-to-consumer tests have sold briskly even while the companies tried to sort out whether or how their systems would be regulated by the FDA. Then last month, Pathway took the next big step, offering to sell their tests over the counter in the nation’s largest drugstore chain, Walgreens.

For the FDA, that was one step too far, and it began to make noise about regulation. Now the agency’s leader in this field, Alberto Gutierrez, has sent official letters to all the major personal DNA-testing companies saying it intends to regulate the tests as medical devices, and that the companies must provide evidence of their scientific validity.

The letters, posted on the F.D.A. Web site on Friday, say the companies must apply for approval or discuss with the agency why certain test claims do not require such approval. But the letters stop short of saying the tests must be taken off the market until they are approved. Dr. Gutierrez said in an interview that it would be unfair to remove the tests from the market because the agency had not clearly told the companies that the devices needed approval [The New York Times].

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Walgreens' Genetic Tests on Hold, Under Congressional Investigation

By Andrew Moseman | May 20, 2010 1:41 pm

PathwayWhen Walgreens, the nation’s biggest drugstore chain, announced last week that personal genomics tests would join diet soda and pregnancy tests in its aisles, we gave some reasons that might not be such a great thing. We weren’t the only ones concerned: The Food and Drug Administration said it would investigate the tests, and now Congress is involved. It opened an investigation into personal genomics tests yesterday.

House Committee on Energy and Commerce, chaired by Rep. Henry A. Waxman, just sent out official requests for information to the big three personal genomics companies—23andMe, Navigenics, and Pathway Genomics.

Waxman’s interest was piqued by the move—quickly rescinded last week after the FDA objected—by Pathway to sell its DNA-collection kits in Walgreen’s drugstores. The letters ask the companies for information on, among other things, how they analyze test results to determine someone’s risk for any disease or drug response, and how accurately the DNA tests identify genetic risks [Newsweek].

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5 Reasons Walgreens Selling Personal DNA Tests Might Be a Bad Idea

By Andrew Moseman | May 12, 2010 4:00 pm

WalgreensWhile you’re down at the drug store picking up toothpaste and sleeping pills, why not have your DNA tested? Walgreens says that this month it will become the first drug store to offer personal genomics tests in its store. For the low, low price of $20-30 you can pick up a kit to take a sample of your own saliva, which you mail off to Pathway Genomics, a company partnering with Walgreens.

Customers can then go Pathway’s Web site and order tests. Pathway says the tests — for drug response, “pre-pregnancy planning” and “health conditions” — start at $79 and run up to $249 for all three [AP].

With the personal genomics trend continuing to accelerate, this was perhaps an inevitable development. But the fact that personal tests are going into drug stores doesn’t mean that personal tests are as readily reliable or regulated as the rest of the tests and medications that fill the aisles.

1. The FDA is not pleased.

The Pathway test has not been approved by the Federal Drug Administration. In a statement after announcing this deal, Walgreens washed their hands of responsibility in this regard, saying Pathway assured them that the product didn’t require FDA approval. The FDA, however, does not agree.

In a statement, the FDA said it has regulatory authority over all lab-developed tests. “As new technologies become available and are marketed directly to consumers, FDA will consider all regulatory options,” the agency said. “Consumers should understand that the claims made by a company with an unapproved test have limitations and that they should not be making important medical and lifestyle decisions without first consulting a health care professional” [Wall Street Journal].

The FDA isn’t the only public body worried about these tests. Here in New York, where DISCOVER is located, we won’t be able to run down to Walgreens and pick up a DNA test. The state considers these to be medical tests, and medical tests require a license. When personal genomics companies first began to spring up, New York State issued nearly 40 cease-and-desist orders in 2007 and 2008. It’s still going to take some time to sort out the legality of who can look into your genome.

2. Can you actually learn anything useful?

Remember, only six years have passed since the human genome was fully sequenced. Incorporating personal genomics into medicine is moving fast, but it’s still in the early stages.

In most cases, the current level of DNA scanning technology and science is unable to offer meaningful predictions about the risk that a person will get a disease. “It is a really wonderful form of recreation,” said Scott R. Diehl, a geneticist at the University of Medicine and Dentistry of New Jersey. But as for applying it to health care, he said, “It’s very premature” [The New York Times].

The tests by personal genomics companies like 23andMe and Pathway look at particular point mutations that scientists think to be associated with diseases like Alzheimer’s or cystic fibrosis. Making clear predictions from a person’s DNA, though, will require not only a further understanding of what genes are linked to what diseases, but also how those genes interact with environmental factors, lifestyle choices, and each other, as our reporter found out in 2008 when having her DNA examined by several of the most prominent companies.

All that knowledge won’t come fast, or cheap.

That might take a few years and require sequencing a person’s entire genome, not just sampling selected bits, as the companies do now [The New York Times].

3. Overreaction—and mixed results

As the FDA noted in its statement quoted above, customers must understand the limitations of these tests—and not act too drastically. As DISCOVER’s own Kat McGowan wrote last year, “Another worry is that people may overreact to their results. Someone who has an elevated risk of breast cancer, for example, might take a drastic step like getting a mastectomy, not realizing that the test predicts increased risk, not a particular outcome.”

Then again, if you get curious enough to try multiple tests, you might have the opposite problem. Some curious folks who’ve tried out multiple personal genomics firms have received contradictory answers.

4. The fine print

Even if you don’t act on the information that a personal genetic test brings, it could impact you emotionally to learn about your ancestry or your family (say, if your father wasn’t your genetic father). That’s why the fine print on personal-genomics products is so extensive.

And the ramifications could do beyond the emotional realm. The Genetic Information Nondiscrimination Act of 2008 offers some protection for personal genetic information, but how much is not terribly clear. Things are changing fast in the world of personal genomics, and it may be difficult or impossible to predict the significance, or even risk, of information you learn in 2010. As 23andMe’s terms and conditions notes:

Even if you share genetic information that has no or limited meaning today, that information could have greater meaning in the future as new discoveries are made. If you are asked by an insurance company whether you have learned genetic information about health conditions and you do not disclose this to them, this may be considered to be fraud.

5. Ready for the shelves?

Still, though, why shouldn’t you have the choice of whether to test your own genome? You get to test yourself in other health capacities:

Drug stores already carry a variety of diagnostic tests, like those for pregnancy, cholesterol and blood sugar. When some of these tests were introduced, there was controversy about whether consumers could test themselves.

Although broader in scope, Pathway’s test is not the first DNA-based analysis to be sold in drug stores. Sorenson Genomics began selling a paternity test through Rite Aid stores in late 2007. Sorenson has sold more than 100,000 tests through Rite Aid and other major pharmacy chains since then, according to Jacob Moon, a spokesman for the company [The New York Times].

But personal genomics is a different ballgame. Paternity tests and pregnancy tests bring you clear yes-or-no answers; they don’t evaluate complicated, multifactorial questions like those that personal DNA tests try to answer. And that complexity may be more than consumers bargained for.

Related Content:
DISCOVER: How Much Can You Learn from a Home DNA Test?
DISCOVER: Your Genome, Now Available for a Relative Discount
Gene Expression: Creative Destruction in Personal Genomics
Gene Expression: Personal Genomics Is Dead; Long Live Personal Genomics

Image: flickr / twodolla

CATEGORIZED UNDER: Health & Medicine

Now For Sale at Fire Sale Prices: Thousands of People's Genomes

By Aline Reynolds | November 18, 2009 4:47 pm

dna-sequence-webDeCode Genetics, a genome sequencing and drug development company, found out the hard way that predicting disease risk simply by reading someone’s genes isn’t so straightforward. On Tuesday, deCode filed for chapter 11 bankruptcy protection in Delaware. The company’s financial problems have also raised some troubling questions about genetic privacy.

DeCode’s mission was to uncover genetic risk factors for common diseases and to develop personal genome scans so individuals could learn their risk. DeCode quickly became the leader in the worldwide race to identify the causes of common disease. The company’s researchers discovered mutations linked to schizophrenia, heart disease, diabetes, prostate cancer and many other illnesses. Its approach was to identify the mutations first in Icelanders and then to confirm them in other populations [The New York Times]. Iceland was seen as an ideal spot for genetic studies, because the population was fairly isolated and the country has excellent medical and genealogical records. However, the company’s early successes did not translate into dollars, in part because the mutations they found only account for a small percentage of the overall incidence of a given disease.

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Want Your Genome Sequenced? Got $68,000? Try Your Luck on eBay!

By Aline Reynolds | April 23, 2009 3:59 pm

genome“People ordered genomes for Christmas” [The New York Times], says the chief executive of the personal gene-sequencing company Knome, commenting on the recent increased demand for his company’s services. Now, Knome is partnering with the non-profit X Prize Foundation to auction its complete genome scan service on eBay. Bidding will open at $68,000—far below Knome’s current price of $99,000. The auction starts Friday and will continue for 10 days. The highest bidder will walk away with a full readout of their gene map, along with a complete interpretation of their genetic details [CNN].

The auction is essentially a publicity stunt [The New York Times] for the company, and is set to begin Friday in order to coincide with DNA Day, the anniversary of the discovery of the double helix structure. Proceeds will benefit the X Prize Foundation, an educational institute offering a $10 million prize for the sequencing of 100 genomes in 10 days for less than $10,000 per genome. Knome and other personal genetics companies claim that besides identifying risk of diseases, sequencing can also determine an individual’s potential reaction to certain drugs and pick out those that may be ineffective or even toxic…. Genomics plays a critical role in the move towards personalized medicine [CNN].

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CATEGORIZED UNDER: Health & Medicine, Technology

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