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80beats

Posts Tagged ‘Tasmanian devil’

Puffers, Platypi & Penises With Teeth: 8 Surprising Genomes That We’ve Sequenced

<p class="MsoNormal">It’s been over 30 years since scientists sequenced the first <a href="http://en.wikipedia.org/wiki/Genome">genome</a>—that of a particular bacteria-infecting virus called <a href="http://en.wikipedia.org/wiki/Bacteriophage">bacteriophage</a> fX174—and they've only gotten better at it since then. Many of the genomes that researchers have chosen to map are obvious choices, like disease-causing bacteria, but some might surprise you. Here are a few of the interesting genomes scientists have sequenced, starting with one of the most recent: the naked mole rat.</p>
<p class="MsoNormal">The <a href="http://en.wikipedia.org/wiki/Naked_mole_rat">naked mole rat</a> is a remarkable creature—OK, it’s downright freaky—that’s said to look like a penis with teeth. They live entirely in underground tunnels and never see the sun; have long life spans for their size (30 years compared to a common rat’s 4 years); feel no pain in their skin; survive and thrive in oxygen-poor environments; and are resistant to strokes and a number of diseases, cancer included. Last week, a research consortium posted the <a href="http://www.naked-mole-rat.org/">draft sequence of the naked mole rat’s genome online</a>; further study may unlock the genetic clues to this unique animal’s survival abilities.</p>
<p class="MsoNormal"> </p><p>An international team of researchers recently <a href="http://blogs.discovermagazine.com/80beats/2011/06/29/we-have-the-tasmanian-devils-genome-will-it-help-save-them-from-extinction/">mapped the genome of these little devils</a> in hopes of saving them from extinction. The <a href="http://en.wikipedia.org/wiki/Tasmanian_devil">Tasmanian devil</a> population has decreased by an alarming 70 percent since 1996 because of a <a href="http://en.wikipedia.org/wiki/Devil_facial_tumour_disease">deadly cancer</a>. Researchers and conservationists plan to use the animal’s genome to selectively breed diverse individuals, widening the gene pool and making future generations more resistant to diseases.</p>
<p> </p><p class="MsoNormal">Late last year, a consortium led by confectioner Mars Inc. announced that it completed sequencing <a href="../80beats/2010/09/15/cacao-trees-genetic-secrets-may-bolster-the-chocolate-supply/">a draft of the cocoa tree’s genome</a>. They posted the sequence online at the <a href="http://www.cacaogenomedb.org/">Cocoa Genome Database</a>. At the same time, rival chocolate maker Hershey also announced that researchers it funded had mapped the cocoa genome, later <a href="http://www.nature.com/ng/journal/v43/n2/full/ng.736.html">publishing results in<em> Nature Genetics</em></a>. By analyzing the tree’s genes, scientists hope to be able to develop pest- and disease-resistant <a href="http://en.wikipedia.org/wiki/Cocoa_tree">cocoa trees</a>, as well as tastier cocoa varieties.</p>
<p class="MsoNormal"> </p><p class="MsoNormal">A team of researchers at MIT revealed in 2007 that they <a href="http://www.nature.com/nature/journal/v447/n7141/full/nature05805.html">deciphered the DNA of the gray short-tailed opossum</a>, the first <a href="http://en.wikipedia.org/wiki/Marsupial">marsupial</a> to have its genome mapped. Some scientists believed that opossums—and marsupials in general—have a primitive immune system because they lack key proteins found in placental mammals (the non-marsupials) that regulate immunity. But when the researchers compared the genomes of opossums and humans, they <a href="../loom/2007/05/09/did-grandma-have-a-pouch-and-other-thoughts-on-the-opossums-genome/">found a surprising number of similar immune-related genes</a>, meaning it’s useful for just the opposite of the expected reason: The gray short-tailed opossum is a nice <a href="http://en.wikipedia.org/wiki/Model_organism">model</a> for immunology research.</p>
<p class="MsoNormal"> </p><p class="MsoNormal">Biologists have long considered the <a href="http://en.wikipedia.org/wiki/Platypus">platypus</a> a fascinating creature, resembling a hodgepodge of different animal parts. And in 2008, when researchers at Louisiana State University <a href="http://discovermagazine.com/2009/jan/090">sequenced the platypus genome</a>, they discovered that its DNA is actually a mash-up of mammalian, avian, and reptilian features. This discovery supports the idea that the platypus represents an ancient branch on the mammalian tree.</p>
<p class="MsoNormal"> </p><p class="MsoNormal"><a href="http://en.wikipedia.org/wiki/Fugu">Fugu</a>—the poisonous puffer fish <a href="http://japanesefood.about.com/cs/seafoodfish/a/fugublowfish.htm">sought after by brave suchi-eaters</a>—has the smallest known <a href="http://en.wikipedia.org/wiki/Vertebrate">vertebrate</a> genome. When researchers <a href="http://www.jgi.doe.gov/News/news_7_25_02.html">unraveled its genetic structure in 2002</a>, they found that 75 percent of its genes have direct human counterparts, even though the fish and humans diverged from their common ancestor over 400 million years ago. By comparing human and fugu genomes, researchers found almost 1,000 previously unidentified human genes.</p>
<p class="MsoNormal"> </p><p class="MsoNormal">Last year researchers <a href="../80beats/2010/06/21/will-unlocking-the-genome-of-body-lice-help-us-destroy-them/">sequenced the genome of body lice</a>, one of our long-time enemies. <a href="http://en.wikipedia.org/wiki/Body_louse">Body lice</a>, which feed on your blood and nothing else, spread many diseases, including <a href="http://en.wikipedia.org/wiki/Typhus">typhus</a> and <a href="http://en.wikipedia.org/wiki/Trench_fever">trench fever</a>. Scientists have learned that the lice genome is incredibly streamlined and the critters have few genes that could detoxify harmful chemicals, as explained in an article in <em><a href="http://www.pnas.org/content/early/2010/06/16/1003379107">PNAS</a></em>. By exploiting that weakness, we may be able to finally defeat this pest.</p>
<p class="MsoNormal"> </p><p class="MsoNormal">The <a href="http://en.wikipedia.org/wiki/Sponge">sea sponge</a> may seem like an odd choice for genomic research considering that its simple body lacks muscles, organs, and nerve cells, but the creature provides a wealth of information on <a href="http://www.nature.com/nature/journal/v466/n7307/full/nature09201.html">how multicellular organism arose</a>. When <a href="../notrocketscience/2010/08/06/pocket-science-%E2%80%93-lessons-from-spongy-genomes-and-a-deadly-bat-killing-disease/">researchers sequenced the sponge’s genome in 2010</a>, they found genes that help individual cells cooperate as a group: how to divide, send signals to one another, and distinguish between friends and outsiders. The sponge genome also contains cancer-related genes, suggesting that individual cells have needed to defend against cancer for as long as they’ve co-existed in the same body.</p>
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July 12th, 2011 Tags: cocoa, DNA sequencing, fugu, genetics, genomics, lice, naked mole rat, opossum, platypus, puffer fish, sea sponge, Tasmanian devil
by Joseph Castro in Environment, Living World, Top Posts | 7 Comments » | RSS feed | Trackback >

We Have the Tasmanian Devil’s Genome. Will It Save Them From Extinction?

What’s the News: Due to a vicious disease, the population of the endangered Tasmanian devil has decreased by at least 70 percent since 1996. The cancer, devil facial tumor disease, spreads when an infected devil bites another, typically during feeding or mating. Because Tasmanian devils are so genetically similar, their bodies don’t recognize the intruding cancer cells as foreign.

But now, researchers have sequenced the genome of two devils and created a genetic test that could help breeders select genetically diverse mates. The test will help conservationists breed future generations of Tasmanian devils that are prepared for the cancer, as well as other types of diseases.

(more…)

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June 29th, 2011 Tags: animals, cancer, diseases, genetic diversity, genome, habitat loss, infectious disease, Tasmanian devil
by Joseph Castro in Environment, Living World | 1 Comment » | RSS feed | Trackback >

Extinct Tasmanian Tiger May Have Screwed Itself by Inbreeding


Tasmanian tigerThe Tasmanian tiger may have been threatened by inbreeding before humans hunted the marsupial into extinction, a new genetic analysis suggests. The last captive tiger died at a Tasmanian zoo in 1936 after a decades-long effort by farmers and hunters to kill the creatures and collect a government bounty, but the new study suggests that the tigers’ lack of genetic diversity left them particularly vulnerable to the human onslaught and outbreaks of disease. “It’s looking like the thylacines were sort of on their last legs,” says Webb Miller [Science News], one of the coauthors.

Researchers sequenced the mitochondrial DNA of two Tasmanian tigers, more properly known as thylacines, from tissue samples preserved at museums in Sweden and the United States. And while the researchers’ main goal was to investigate the roots of the thylacine’s extinction, they acknowledge that having a complete genome at their disposal is sure to prompt talk of cloning. Says Miller: “Our goal is to learn how to prevent endangered species from going extinct…. I want to learn as much as I can about why large mammals become extinct because all my friends are large mammals,” Professor Miller added. “However, I am expecting that publication of this paper also will reinvigorate discussions about possibly bringing the extinct Tasmanian tiger back to life” [BBC News]. Some scientists think that the thylacine would be one of the easiest extinct animals to resurrect, as it died out recently and several well-preserved specimens exist in museums.

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January 13th, 2009 Tags: cloning, endangered species, extinction, genetics, Tasmanian devil, Tasmanian tiger
by Eliza Strickland in Living World | 23 Comments » | RSS feed | Trackback >





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