Blogs / 80beats

It doesn’t matter if they only smoke when the kids are out of the house, or when they’re alone in the car, or even if they only smoke outside; researchers still warn that toxic chemicals exhaled by cigarette smokers cling to their clothes and hair, and linger in upholstery, curtains, and carpets. In a new study, researchers say the public is well aware of the health effects of second-hand smoke, when nonsmokers are directly exposed to the cigarette smoke of others, but hasn’t yet caught on to the danger of what they call “third-hand smoke.” Lead author Jonathan Winickoff explains that third-hand smoke is what one smells when a smoker gets in an elevator after going outside for a cigarette, he said, or in a hotel room where people were smoking. “Your nose isn’t lying,” he said. “The stuff is so toxic that your brain is telling you: ’Get away’” [The New York Times].

The researchers say that there is no safe level of exposure to tobacco smoke, and note that children are particularly susceptible to ill-effects from the toxic residue left behind long after a cigarette has been stubbed out. Among the substances in third-hand smoke are hydrogen cyanide, used in chemical weapons; butane, which is used in lighter fluid; toluene, found in paint thinners; arsenic; lead; carbon monoxide; and even polonium-210, the highly radioactive carcinogen that was used to murder former Russian spy Alexander V. Litvinenko in 2006. Eleven of the compounds are highly carcinogenic [The New York Times].

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Cancer will be the world’s leading killer by 2010, edging out heart disease for the top spot, according to the latest report by the World Health Organization (WHO). Though cancer rates in the United States have just recently begun to decrease, elsewhere in the world cancer is on a steady rise. Experts cite tobacco, increasingly Western lifestyles, and inadequate medical care as the factors contributing to the cancer epidemic in developing countries. “In the U.S., we pay a lot of attention to cancer trends, and the trend has been encouraging,” says Dr. Richard Schilsky… “But we have forgotten that there is a big wide world out there. Cancer is a global problem” [TIME].

According to the WHO report, 12 million new cases of cancer will be diagnosed this year and 7 million will die from the disease. The group forecast a 1 percent increase globally each year, with emerging economies such as China, Russia and India being hit the hardest [CNN]. The report also projects a 38 percent population increase in less developed countries by 2030. Taken together, that means by 2030 an estimated 20 to 26 million new cases of cancer will be diagnosed annually and 13 to 17 million deaths will be cancer-related.

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When a hummingbird or a hawk moth sups on the sweet nectar of a wild tobacco plant, they’re not just getting a tasty meal in exchange for their services in spreading the plant’s pollen. Instead, a new study shows that the nectar may be a complex chemical cocktail that simultaneously attracts and repels pollinators in order to optimize the amount of time they spend at each flower, and the attention they pay to flowers on different plants. “This paper shows just how sophisticated a plant can be in using chemistry to get what it wants,” [The Scientist] says lead researcher Ian Baldwin.

The researchers had already analyzed the chemical composition of tobacco plants’ nectar; they found that the compound benzyl acetone is the primary attractant, and that the plants “spike” their nectar with nicotine, presumably as a poisonous deterrent to insects. But in a clever experiment, the research team created genetically modified plants with different levels of these two chemicals. In greenhouse and field experiments, the scientists were surprised to find that not only did nicotine deter nectar robbers and plant nibblers, but the right dose prevented pollinators from lingering too long at any one flower, increasing the number of flowers visited [Science News].

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Researchers say they have turned a tobacco plant into a living factory that can produce individualized vaccines to fight a type of cancer known as follicular lymphoma. While similar vaccines have been grown inside animal cells, researchers say this new process is quicker and less expensive, and could carry less risk to the patient, as animal cells might hold unknown viruses [BBC News].

In the new technique, researchers took biopsies from each lymphoma patient and isolated the gene that produces tumor-fighting antibodies, which is slightly different in each person. In each case, they then used a genetically engineered tobacco virus to bring the gene into a tobacco plant, where the plant responded by turning out antibodies. One week later the tobacco leaves were picked and ground into pulp, and the antibodies were extracted. These antibodies are put into a patient newly-diagnosed with the disease, to “prime” the body’s immune system to attack any cell carrying them. If successful, this would mean the body would then recognise and destroy the lymphoma cells [BBC News].

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