Bioengineers have made great strides harnessing the body’s ability to start over, whether regenerating heart tissue and bones, or using stem cells to regrow fingertips. Still, much of regenerative medicine’s promise remains inside the laboratory—or at least that was what I thought when I began reporting for The Body Builders: Inside the Science of the Engineered Human.
Some clinicians, like Dr. Eugenio Rodriguez, aren’t waiting for trials to be completed to help patients. Instead, they are already adding regenerative technologies to their medical toolboxes, and using them to save human limbs. Years ago down in Delray Beach, Florida, Rodriguez, a trauma surgeon, caused a bit of a sensation after exploring the regenerative powers of pig guts. Read More
Many cultures swear by the benefits of a hot bath. But only recently has science began to understand how passive heating (as opposed to getting hot and sweaty from exercise) improves health.
At Loughborough University we investigated the effect of a hot bath on blood sugar control (an important measure of metabolic fitness) and on energy expended (number of calories burned). We recruited 14 men to take part in the study. They were assigned to an hour-long soak in a hot bath (40˚C) or an hour of cycling. The activities were designed to cause a 1˚C rise in core body temperature over the course of one hour. Read More
In January 1958, two medical officers at Porton Down, Britain’s military science facility, exposed their forearms to 50-microgram droplets of a substance called VX, which was a new, fast-acting nerve agent that could kill by seeping through the skin.
VX, short for “venomous agent X,” is tasteless, odorless and causes uncontrollable muscle contractions that eventually stop a person’s breathing within minutes. That experiment in 1958, according to University of Kent historian Ulf Schmidt, was perhaps the first human test of VX in the Western world. Read More
Pathogens move fast.
You wake up one morning feeling ready to take on the world. On your way to work, you notice your throat’s a bit scratchy, your forehead a bit warm. By lunch you’ve got a pounding headache and it hurts to breathe. Co-workers agree, you’ve got whatever’s been going around. You end the day early, using the last of your strength to drag yourself to bed. Read More
In the long view, modern history is the story of increasing rights of control over your body – for instance, in matters of reproduction, sex, where you live and whom you marry. Medical experimentation is supposed to be following the same historical trend – increasing rights of autonomy for those whose bodies are used for research.
Indeed, the Nuremberg Code, the founding document of modern medical research ethics developed after the Second World War in response to Nazi medical experiments, stated unequivocally that the voluntary, informed consent of the human subject is essential. Every research ethics code since then has incorporated this most fundamental principle. Exceptions to this rule are supposed to be truly exceptional. Read More
The concept of being able to predict the sex of a baby during early pregnancy or even influence it by eating or doing certain things when trying to conceive has been the subject of public fascination and debate for many centuries. But surely the sex of a fetus is exclusively determined by the father’s sperm, carrying an X chromosome for girls and a Y chromosome for boys?
It turns out this is not the full story. Since the 17th century, it has been recognized that slightly more boys are born than girls. This is strange – if the sex were determined solely by chromosomes, the probability of either should be 50 percent and not variable. This must mean that, although the same number of boys and girls are conceived initially, more female fetuses than male ones are lost during the pregnancy. Read More
No one wants to catch the flu, and the best line of defense is the seasonal influenza vaccine. But producing an effective annual flu shot relies on accurately predicting which flu strains are most likely to infect the population in any given season. It requires the coordination of multiple health centers around the globe as the virus travels from region to region. Once epidemiologists settle on target flu strains, vaccine production shifts into high gear; it takes approximately six months to generate the more than 150 million injectable doses necessary for the American population. Read More
Earlier this week, a story begging to go viral fell onto writers’ laps: We have a new organ called the mesentery, which is a broad, fan-shaped fold that lines the guts. Here at Discover we pounced on the story, and so did CNN, the Washington Post, LiveScience, Smithsonian, Vice News Tonight, Jimmy Kimmel and many, many more.
We got it all wrong, and it’s time for us to spill our guts.
In our reporting, one burning question we wanted answered was who, or what, determines when a hunk of tissue “officially” becomes an organ. So we posed the question to J. Calvin Coffey, the Limerick University Hospital researcher who presented evidence in The Lancet Gastroenterology and Hepatology to “justify designation of the mesentery as an organ.”
“That’s a fascinating question. I actually don’t know who the final arbiter of that is,” he told us. Read More
Most women experience some type of morning sickness during pregnancy, but some women develop a far more serious condition.
Hyperemesis gravidarum (HG), which causes severe nausea and vomiting during pregnancy, affects as many as 3 percent of pregnancies, leading to over 167,000 emergency department visits each year in the U.S.
And yet, the disease is neither well-understood nor well-known, even with the flurry of headlines when it was announced that the Duchess of Cambridge during her pregnancies suffered from the condition. Read More
Advances in reproductive technology may radically change the options we have for starting a family. We’re not too far from fundamentally redefining what it means to start a family.
Do you want to have children, but don’t have a partner? Do you want children with your partner, but it’s a same-sex relationship? Or perhaps you’re a woman who wants children without the burden of a 9-month pregnancy. You might opt for ectogenesis, or moving gestation to an artificial womb.
Here’s a glimpse of this brave new world of baby-making. Read More