Slug-Inspired Glue Can Heal a Broken Heart

By Breanna Draxler | January 9, 2014 11:56 am
heart surgery

Heart surgeries may one day be less invasive and require less healing time with this bio-inspired glue. Image credit: fivepointsix/Shutterstock.

When it comes to mending a broken heart, researchers say they may have found the key. And it comes in the form of a slug-inspired glue.

Most heart defects today are fixed via surgeries that involve stitches or staples. But these sutures can do damage to the heart’s fragile tissue, especially because the heart still has to stretch and strain to pump blood as it heals. And while surgical glues do exist, they are meant to close up skin wounds—some are toxic while others simply can’t stick to a wet, beating heart.

Inspired by Slugs

But what can stick to slippery surfaces and still move around? Slugs. These slimy creatures secrete extremely sticky adhesives that (as the hikers among you may know) work even on rain-wet rocks and mud-slicked trails.

A team from Boston Children’s Hospital and MIT mimicked the slug’s slime in the lab and came up with an adhesive that is über sticky, water- and blood-proof, and dries in seconds via UV light. It’s even biodegradable.

bio-inspired glue helps heal heart wounds

The waterproof, light-activated glue can successfully secure biodegradable patches to seal holes in a beating heart. Image credit: Karp Laboratory

Sticking to the Heart

To test the glue, researchers used pig hearts, which are pretty anatomically close to the human version. The hearts had holes in some of the trickiest spots to mend: pulsing cardiac walls and big, high-pressure blood vessels.

The researchers applied the glue, which they call “hydrophobic light-activated adhesive” or HLAA, to small biodegradable patches, which they affixed to the holes. They then shone a UV light to activate the adhesive. In less than five seconds, the holes were sealed, and the stretchy sealant held for a 24-hour monitoring period.

In the real world, glued patches would need to stay in place long enough for the heart to heal over the wound, so long-term testing is necessary and next on the researchers’ list.

Super Glue to the Rescue

The slug-inspired glue could lead to less-invasive surgeries and faster healing times, which is good news for the 40,000 babies born with congenital heart defects in the U.S. each year. The researchers say it could also be used on other slippery moving parts like the intestines, as well as emergency surgeries where quick sutures are necessary to take care of a trauma.

The paper, published in Science Translational Medicine, suggests this stuff could be ready to roll out to market in two to three years, assuming long-term trials and human testing prove successful.

CATEGORIZED UNDER: Health & Medicine, top posts
  • Arthur Smith

    Thanks slugs! <3

  • Linda Henchon

    What will they think of next? God has provided all cures in nature. Apparently science just has to find them. Interesting article.

    • john doe

      What an awesome god, giving us glue to fix hearts. He also provides unbelievers for muslims to slaughter, rape, rob, burn their homes and churches, take their lands, or execute them for being atheist or gay. God has also provide the right sized rocks to stone women to death for adultery or for being raped. God is great is he not?

    • Dilbert

      Which god(s) – the Sun god or some other man-made BS god(s)? Throughout history, the masses have always spread their superstitious dung and subjugated non-believers! So, congrats – you are them! :)

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