Pig Hearts Could Someday Beat in Human Chests

By Carl Engelking | April 30, 2014 1:52 pm

pigs

A new source for desperately-needed heart transplants is a step closer to reality. Scientists reported this week that pig hearts transplanted into baboons have lasted more than a year without being rejected—a promising step toward using such organs for human transplants. Until now, pig hearts transplanted into primates had only lasted a maximum of six months before they were rejected.

Roughly 3,000 people in the United States are on the waiting list for a heart transplant on any given day, but only 2,000 hearts become available each year. The new advancement offers hope that pig hearts could someday help meet this need.

Making a Switch

Pigs are anatomically similar to humans, so they make an ideal candidate for inter-species transplants. The biggest problem with transplanting organs from animals to humans, however, is rejection from the recipient’s immune system.

In the current study scientists overcame this hurdle by genetically modifying pigs from the time of conception. They excised pig genes known to cause an immune reaction in primates and humans, and added several human genes.

When the pigs were grown they sacrificed them, and implanted the pig hearts into the abdomens of baboons. They didn’t replace the monkeys’ original hearts, but the new hearts were still connected to baboons’ circulatory system. The baboons were also pre-treated with medication to suppress their immune systems. Over 500 days later, the researchers report, the hearts are alive and functioning. The results were presented Monday at a meeting of the American Association for Thoracic Surgery in Toronto.

The next step, researchers say, is to use the same combination of genetic engineering and immunosuppression to fully replace a baboon heart with a pig heart.

 

Photo credit: mubus7/Shutterstock

CATEGORIZED UNDER: Health & Medicine, top posts
  • http://www.mazepath.com/uncleal/qz4.htm Uncle Al

    Pig Hearts Could Someday Beat in Human Chests” “fully replace a baboon heart with a pig heart” Its been done with near 100% success – Congresscritters.

  • Daniel Anderson

    NO..no . no. We are too close to re-growing our own organs – we should be focused on that…not putting in the bacon-blood-beaters….

    • Freelance Philosophy

      If we all work on the same thing someone is wasting time.

      • Daniel Anderson

        True but not really schooling me, here, mr smarty pants. Let’s say a relative gets a pig heart and a stranger gets a new one around the same time. In reflection try saying that again without choking on the words.

        • Freelance Philosophy

          I am sure that different situations will merit different solutions. Creating IPSC colonies from patients’ skin can take weeks, and once you have the steam cells months are required to induce differentiation and structural formation of those steam cells.

          Many people in need of heart transplants simply don’t have the time, while others might.

          Even in a future where every person with high cholesterol has a backup heart growing for them somewhere someone will slip through the cracks and need a heart where preparations have not been made, in the case where that person were you I think you’d take the pig ticker.

          • Daniel Anderson

            nah…that point it’ll be the gene therapy…take out the predisposition for higher tenancy to collect cholesterol deposits. :-)

          • Daniel Anderson

            if all else fails…then mayyyybe…give ya that…but that’s after we exhaust bio-mechanics…..

            oh, what the hay….give me a giraffe heart…lol Leave pig for Christmas dinner and strips on my McMuffin so I can build up that cholesterol…

      • Daniel Anderson

        You’re right… to that logic, then I think someone should start working on a sort of “carriage” that rolls but does not have horses…something powered by some “fuel” of some sort…nobody’s working on anything like that…

  • http://blogs.discovermagazine.com Scott Macdonald

    I’ve often wondered how much of me would have to be in a pig so I wouldn’t reject its organs? Would it be can ableism if you cooked the doner?

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