This Gooey Sponge Is Our Best Model Yet of a Working Brain

By Carl Engelking | August 12, 2014 2:54 pm
sponge brain

Researchers constructed functioning 3-D brain tissue using this doughnut-shaped scaffold. Credit: Tufts University

You may have heard someone’s memory praised with the saying “You have a brain like a sponge.” Well, here’s a twist: a sponge that’s like a brain.

A research team from Tufts University in Boston constructed a functioning 3-D brain model by seeding spongy silk scaffolds with mouse neurons. The researchers’ model was a happy home for cells, since it was a 3-D, layered environment that mimicked the structure of the real thing.

It also functioned like the real thing. Researchers say their model will serve as a useful, nondestructive way to study, in real-time, traumatic head injuries such as concussions.

Building a Brain

Growing artificial brain tissue isn’t new: neurons are routinely grown in a 2-D environment such as a petri dish. However their complex branching structure is nearly impossible to replicate in a flat environment.

To provide a brain-like matrix, researchers started with six layers of silk harvested from moth cocoons, mimicking the six layers of the human cortex (and dyed so they could easily be differentiated). The pores in the layers of scaffolding were varied in size and orientation to simulate the structure of the human cortex. Researchers then seeded this structure with thousands of cortical neurons harvested from rats.

Within days, the neurons started growing, forging connections that spanned the model’s layers – just like they would in a real brain. They also showed similar qualities as neurons in an intact brain, including their electrical activity and responsiveness.

Furthermore, the 3-D structure improved the transport of oxygen and nutrients to the cells, so the cells survived about 9 weeks – longer than other models. Researchers believe they could extend the life of their model by electrically stimulating the tissue to simulate a real-world environment.

Brain Bruising

After building their model, researchers dropped an 11-gram weight from various heights to injure the brain and assess its activity in real time – something you can’t do with humans and animals. The brain tissue’s physiological response to trauma was consistent with past research, proving its efficacy as a model. Researchers published their findings Monday in Proceedings of the National Academies of Science.

Going forward, researchers hope to incorporate other types of brain cells in their model to better mimic the brain’s complexity. Researchers also said scaffolds could be shaped like specific parts of natural brains for an accurate simulation.

As to how long it would be before you could grow your own pet brain by just adding water, however – no word yet.

CATEGORIZED UNDER: Mind & Brain, top posts
  • J. Fischer

    And we have the next Syfy movie, made by The Asylum.

  • Ctr Exc in Nanomed

    Even if this is the most brain-like model that’s yet been engineered from the top down (cerebral organoids are another in vitro model, but quite different since their structure is generated by differentiation from stem cells), it’s still not terribly brain-like. The fact that it has six layers is almost irrelevant, since in this study, all the layers contained the same neurons. Also, the scaffold material used here is vastly different from brain extracellular matrix– it takes up far more space, and according to the authors’ previous work, is far stiffer (this paper shows that the compressive strength of the whole construct is similar to that of chunks of brain, but smaller scale measures are also important).
    This isn’t to say that this work isn’t impressive– the enhanced viability they observe is exciting, and it’s cool to have an in vitro system in which to study responses to direct impact instead of other forms of mechanical deformation.

  • lololololcaster

    I hate to say this… but animal tests. It will be cruel, but we will get far more accurate results.

    I pity the poor mice, but I pity the poor men and women who die or end up disabled much more.


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