http://blogs.discovermagazine.com/discoblog/2009/04/06/when-fruit-gets-deadly-woman-eats-grapefruit-nearly-loses-leg/ Quirky, funny, and surprising science news from the edge of the known universe. Tue, 24 Nov 2009 08:28:02 -0600 http://wordpress.org/?v=2.8.4 hourly 1 http://blogs.discovermagazine.com/discoblog/2009/04/06/when-fruit-gets-deadly-woman-eats-grapefruit-nearly-loses-leg/comment-page-1/#comment-22544 Gwenny Wed, 08 Apr 2009 16:51:42 +0000 http://blogs.discovermagazine.com/discoblog/2009/04/06/when-fruit-gets-deadly-woman-eats-grapefruit-nearly-loses-leg/#comment-22544 Epic story title fail. The conclusion is that it was the trip, not the grapefruit yet you put that misleading title. Epic story title fail. The conclusion is that it was the trip, not the grapefruit yet you put that misleading title.

]]> http://blogs.discovermagazine.com/discoblog/2009/04/06/when-fruit-gets-deadly-woman-eats-grapefruit-nearly-loses-leg/comment-page-1/#comment-22477 Uncle Al Mon, 06 Apr 2009 21:07:58 +0000 http://blogs.discovermagazine.com/discoblog/2009/04/06/when-fruit-gets-deadly-woman-eats-grapefruit-nearly-loses-leg/#comment-22477 Grapefruit (naringin and aglycone naringenin, bergapten, 6',7'-dihydroxybergamottin ) is a potent inhibitor of the intestinal cytochrome P-450 3A4 system. Co-administration with pharma could drastically reduce necessary oral dosages. This would be a financial disaster for the industry - especially for high dose HIV protease inhibitors. Grapefruit (naringin and aglycone naringenin, bergapten, 6′,7′-dihydroxybergamottin ) is a potent inhibitor of the intestinal cytochrome P-450 3A4 system. Co-administration with pharma could drastically reduce necessary oral dosages. This would be a financial disaster for the industry – especially for high dose HIV protease inhibitors.

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