NCBI ROFL: Oh, the irony!

By ncbi rofl | September 30, 2010 7:33 pm

mr peanut(Not funny ha-ha, but unbelievable).

Transfer of peanut allergy from the donor to a lung transplant recipient.

“Among solid organs, transfer of peanut allergy from donor to recipient has been implicated after liver transplantation. We report the first case in which such transfer occurred after a lung transplant. A 42-year-old woman with history of sarcoidosis underwent a successful bilateral lung transplant from a donor who died from anaphylactic shock after eating peanut-related food. Seven months later, she ate a peanut butter cookie at a transplant support group meeting. Immediately thereafter, she developed an anaphylactic reaction, but survived with prompt treatment. During subsequent follow-up, she could recall three prior episodes of wheezing and difficulty breathing after eating peanut-related foods. The first episode occurred 4 days after the transplant. Prior to her transplant, she never had problems eating peanuts. Skin-prick testing confirmed peanut sensitization. She avoided peanuts and, although her skin-prick test became negative, she still manifested peanut allergy when formally challenged orally with the food. She was advised to continue abstaining from all peanut-related foods. This case emphasizes the importance of considering donor allergy transfer when caring for all solid-organ transplant recipients in order to avoid a life-threatening event.”


Photo: flickr/Digiart2001 | jason.kuffer

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  • kate C.

    There is a great case study problem to use with students in an immunology class or other sort of bio class that is based off of a similar case. I used it with my immunology students last spring and it went really well. I found it on the big Buffalo case studies page. In that (true story) the donor with the peanut allergy’s organs went to two people, and one person developed the allergy and the other didn’t – some of the organs passed it on, the other didn’t. Interesting stuff!

  • Katharine

    This is not terribly surprising.

    Although it does state the importance of exposing people to various things at early ages – bored immune systems make for miserable people.

  • chris

    Allergies seem to be genetic, it doesn’t matter what your exposed to at a young age, if your allergic you will have a reaction even if you are very young

  • BmoreKarl

    Look up NCBI on Urban Dictionary. This blog doesn’t seem to offer an alternative meaning (google turns up several), but in that context, NCBI ROFL is confusing.

  • Chris

    Allergies are both genetic and dependent on exposure. There’s plenty of research to suggest that under-challenged mast cells will over-react to allergens. Constant exposure to a particular allergen can actually yield a decreased allergic response over time as the mast cells adapt.

  • Natasha

    I have many different types of allergies, all food and pollen related and I recently developed asthma (I actually spent most of the night in the ER because of my asthma). My asthma, a form of reaction to an allergy, was actually caused by smoking. My allergies all developed around the time I was 8 to 12 and nobody in my immediate family has allergies, and I think out of my entire extended family, only about 2 people are allergic to anything at all, and that’s usually just one or two things, not the 15 things I’m allergic to. In my experience, I don’t think genetics played a role at all.

  • Mr Anonymous

    This story almost sounds like an urban legend “…at a transplant support group meeting…”. The story seems plausible (although I can imagine her allergy is due to a suppressed immune system not the lungs) but the story seems to pile on alot of coincidental facts and places. Really? At a transplant support group meeting? How nice. There’s too much irony here for this to be a REAL story. Hey, you never know though.

  • ringo

    Um, Mr Anon, if it gets published and makes its way to Pub Med, it’s not like you heard it from a friend-of-a-friend…

  • Jennifer Welsh

    @ Mr. Anon. Just thinking about your comment, aren’t allergies caused by an over-active immune system (attacking things it should be neutral to), so being on immune suppressants would suppress the allergies, also.

  • Mr Anonymous

    Just don’t believe everything that you read especially online! Even “respectable” online publications have been known to pick up or reprint bad information or have unethical posters. It may be true, but it follows the method of an urban legend too well.

  • IDunnoLol

    Please learn the definition of “irony.” It’s the exact OPPOSITE of irony.

  • poslatkvetiny

    I am running a site and i liked yours. Can you help me with this? Thanks!


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About ncbi rofl

NCBI ROFL is the brainchild of two Molecular and Cell Biology graduate students at UC Berkeley and features real research articles from the PubMed database (which is housed by the National Center for Biotechnology information, aka NCBI) that they find amusing (ROFL is a commonly-used internet acronym for "rolling on the floor, laughing"). Follow us on twitter: @ncbirofl


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