Neandertals had red hair! (OK, some)

By Razib Khan | October 25, 2007 1:59 pm

Sometimes science is just too cool! A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals:

The melanocortin 1 receptor (MC1R) regulates pigmentation in humans and other vertebrates. Variants of MC1R with reduced function are associated with pale skin color and red hair in humans primarily of European origin. We amplified and sequenced a fragment of the MC1R gene (mc1r) from two Neanderthal remains. Both specimens have a mutation not found in ~3700 modern humans. Functional analyses show that this variant reduces MC1R activity to a level that alters hair and/or skin pigmentation in humans. The impaired activity of this variant suggests that Neanderthals varied in pigmentation levels, potentially to the scale observed in modern humans. Our data suggest that inactive MC1R variants evolved independently in both modern humans and Neanderthals.


neanderthalchild.jpgThe researchers took two Neandertal remains, extracted samples, and amplified the MC1R region. They were sniffing for a region which exhibited differences from modern human populations because likely contamination with H. sapiens sapiens DNA would make it difficult to distinguish sequences which were identical by state. Luckily something turned up, a non-synonymous substitution of an A to a G which encoded the amino acid Arginine instead of Glyceine. This SNP doesn’t seem to be found in modern human populations, they searched a sample size on the order of thousands, so if it is extant within our species it is at a very low frequency (and even if that particular SNP existed it is possible that it is a different mutation). They also checked to see if it might have been animal contamination, and that seems unlikely as the region around the SNP of interest didn’t seem fishy. Multiple extractions were performed and this SNP was detected in many of them independently, suggesting that it is authentic ancient DNA. Finally, they also ruled out the likelihood that later chemical processes could have generated the SNP after the death of the individuals in question.
The authors noted that comparisons with other taxa implied that this location was under functional constraint, which suggests that the amino acid change might have phenotypic implications. Now, one commonly thinks of these sorts of evolutionary genetic studies as historical sciences of inference, but this group went a little further. With some quick molecular genetic footwork they showed that the SNP in question does seem to result in reduced activity of the MC1R locus! From this the authors conclude that there was loss of function due to this genetic change at MC1R. Just to be sure they also checked contemporary loss of function mutations on MC1R, those known to result in fair skin and red hair, and the activity was indistinguishable.
I won’t go into the statistical inferences that they made from this N = 2. Yes, I know that they’re p-values, but sometimes it is enough to say that it is rather suspicious that two different Neandertal samples from distinct locations (one in Spain, the other in Italy) yielded the same unique SNP, which is not found in modern populations. Neandertals and proto-Neandertal populations were extant across northern Eurasia for nearly an order of magnitude longer than modern humans have been, they had a long time to adapt to local ecological conditions. If low UV levels select for lighter skin, Neandertals should have had lighter skin. I have argued in this space that lightening of skin might be relatively recent in human evolutionary history; perhaps a response to poor nutrition due to the shift to agriculture. These data suggest rather that high latitudes and low UV are also sufficient conditions, as no one would posit that Neandertals practiced agriculture. Nevertheless, there were differences between Neandertals and the modern humans who succeeded them in terms of behavior and likely items consumed as food and their proportions. In all honesty I doubt that the diets were different enough that the selective pressures would have been very different from nutrient deficiencies, but I can’t ignore the fact that several skin lightening mutations seem to have increased in frequency rather recently, tens of thousands of years after modern humans settled the north (e.g., at SLC24A5, SLC45A2 and OCA2). It may be that MC1R is under weaker constraint than these loci, which required a more stringent intersection of conditions to be driven to selection for loss of function. Nature is as it is, and our theories need to take into account the twists and turns she throws our way.
Finally, I will add one thing: Europeans are the most polymorphic of world populations on MC1R , there are a host of moderate frequency alleles segregating in the gene pool. Some researchers have argued that this is evidence of relaxation of functional constraint, so that over time neutral loss of function variants built up within the gene pool. But because that time scale would be on the order of hundreds of thousands of years, earlier than human habitation of the north, others have argued that frequency dependent selection might have resulted in the emergence of many alleles which produced novel phenotypes subject to sexual preferences. Within Europeans the variation on MC1R is often hard to attribute to particular phenotypes aside from the combination of red hair and very fair skin. The authors in the above paper dismiss the possibility of gene flow, and that is certainly a straightforward implication when you have an SNP which doesn’t seem extant in moderns. But, as John Hawks has long noted tens of thousands of years is a long time, and if this variation was relatively neutral in fitness in relation to a host of other loss of function mutants which generated light skin it might have simply gone extinct due to drift even if it crossed in human populations. The fact that it is found in two individuals separated geographically suggests it wasn’t particularly rare or localized, but the presence of multiple red hair mutants among modern humans still leaves open the possibility that some of these “jumped” from Neandertals. Also remember that a loss of function mutation is often easy to generate from scratch, so an a priori the model of independent mutations is quite attractive (it might be more likely that Neandertal introgression might occur on gain of function mutants, which are harder to come by and so more valuable).
neandertalclassic.jpgThat’s the science. But what’s the cultural impact? Not much on a grand scale, this is just really cool. Nevertheless, the classic mental image of the Neandertal seems to be of a very dark-haired individual, perhaps a bit swarthy. Then there is the other image of Neandertals as a fairer population prefiguring some of the characteristics of northern Europeans. These physical types are illustrated by two works of first contact between Neandertals and modern humans, Jane Auel’s Earth’s Children series and Dance of the Tiger by Björn Kurtén. In Auel’s work the less advanced Neandertals are a dark-haired race perceived to be subhuman by the blonde Nordic looking anatomically modern populations whom they encounter. Though Auel humanizes the Neandertals in many ways, it remains that on the great chain of being they are the inferior, doomed to extinction. Kurtén, in contrast, depicts the newly arrived modern humans as dark-skinned, and the Neandertals as fair-haired and light-eyed. His logic was simple, a newly arrived population from the south should naturally be less well adapted to high latitudes than a long resident one, and fair complexions were a northern adaptation (Kurtén’s work also presents a peculiar twist in terms of characterizing exactly how modern humans were superior, and why the Neandertals went extinct). In any case, what does the data show? It seems clear that Auel’s picture is not just implausible a priori, the recent data suggests that blue eyes are a relatively recent evolutionary development (on the order of 10,000 years), so the Nordic conquest of Neandertals could not have occurred because the Nordic phenotype itself derived from its antecedents relatively recently.1 And the data above suggests that Neandertals themseves may have been rather fairly complected, so I will finish with a Wikipedia passage concering William Golding’s 1955 novel of first contact between moderns and Neandertals, The Inheritors:

This last chapter is the only one written from the humans’ vantage, and here Golding’s style assumes full depth in the humans’ ability to describe and comprehend what has happened. Interestingly, the humans see the furry, reddish creatures by whom they are beset as a type of forest demon whom they regard with fearful superstition.

Related: I’ve posted a lot about skin and eye color. Kambiz has more commentary.
Note: Red hair emerges because of a lack of balance between the production of dark eumelanin and red-yellow pheomelanin. When both are down regulated in terms of production one obtains ash blonde hair. I am not totally clear as to why the authors above assume that pheomelanin production would also not be effected. Also, I obviously glossed over their molecular genetic confirmation that the SNP in question resulted in loss of function. First, I’m not that interested in molecular genetics outside of an evolutionary context. Second, that means that I would mangle their methods because of my weakness in this area.
1 – Auel also depicts black Africans and East Asians in their modern forms as well. Again, it seems unlikely that either of these types were extant 40,000 years ago. Though Auel aims for verisimilitude, in many ways her works are more likely science fiction than historical fiction, she takes regular modern human psychologies and transports them into exotic locales.

CATEGORIZED UNDER: Genetics
  • J-Dog

    If I recall, Auel also hypothesized the Neandertals not being able to talk. Thanks for the tip on Golding – I will look in my local library for The Inheritors.

  • Jeb, FCD

    The link to DOI infor is broken.

  • http://www.scienceblogs.com/gnxp razib

    fixed.

  • Mowgli

    As an aside – why are Neandertals usually referred to as and evolutionary dead ends? (see bbc story – http://news.bbc.co.uk/1/hi/sci/tech/7062415.stm )
    They had bigger brains, they seemed to have elaborate funerals. These people aren’t simpletons. Excuse the cliche, but let’s not forget auschwitz. A people whose intelligence is higher can be wiped out but a people whose intelligence is lower.

  • http://www.scienceblogs.com/gnxp razib

    As an aside – why are Neandertals usually referred to as and evolutionary dead ends?
    because they didn’t leave descendants. evolution doesn’t care about any characteristic at the end of the day except reproductive fitness. stuff about funerals and big brains is totally irrelevant.

  • rach

    does this mean the Irish are the most pure living descendants of the neandertals?

  • http://www.scienceblogs.com/gnxp razib

    does this mean the Irish are the most pure living descendants of the neandertals?
    the polymorphism isn’t found in any modern population. so no. this is a different variant than modern red heads.

  • rach

    a long time ago on the other gene expression – somebody, g cochran, i think – was saying that they were going to publish findings about a living group of neandertals. did anything come of that?

  • http://scienceblogs.com/gnxp razib

    it is 2 or 3 papers down the line i think. i never asked greg who he thinks they are, but i assume the irish or something. hawks has been talking about morphological overlap between moderns and neandertals for a while now….

  • Edward Haworth

    To be fair to Jean Auel she did backpedal a bit – in some of the sequels there were blonde Neanderthals!

  • http://www.scienceblogs.com/gnxp razib

    in some of the sequels there were blonde Neanderthals!
    which one? i read ‘em all but shelter of the stones or whatever.

  • http://www.writersdailygrind.blogspot.com Anne Gilbert

    Several comments here:
    First, there seem(as I understand it) to be several MC1R variants in “modern” populations. Like GNXP, I don’t totally understand the molecular genetics here, but assuming tht Neandertal red hair(if that indeed is what they discovered) is still another variant that doesn’t happen to be found in “modern” European populations, but functioned pretty much the same way as MC1R in “modern” popuations, several possibilities arise. First, as John Hawks has suggested, introgression. Second possibility. Since the two Neandertal fossils appear to have been separated geographically and the gene was widespread, there may have been other variants as well, possibly one exactly like the “modern” one (for all we know. Or MC1R mutates a lot, but is slightly different in different populations. Since Neandertals aren’t around any more, but they seem to have had other genes that functioned like “modern” ones and were essentially the same thing. It’s probably kind of impossible to tell at the moment, but the discovery itself is exciting!
    Finally, Jean Auel’s portrayal of dark-haired, dark-eyed Neandertals who couldn’t “really” talk, has always struck me as odd. I think it’s a bit of unconscious racial bias, myself, which is one reason I kind of cringe when I hear her name mentioned in other contexts.
    One last thing: That picture of the girl on the top. I know it’s been Photoshopped or something, but that is the most unnatural looking red hair I’ve ever seen! It looks more like the kind of “red” hair some people with a bad dye job get, or else some kids who want to look “punk” or something, will get unnatural looking colors like that and dump them in their own hair! I doubt if any self-respecting Neandertal would have done such a thing, even if the materials had been available (vbg) And if you want to see a much better picture of a redheaded Neandertal(and I Photoshopped her a long time ago, please visit The Writer’s Daily Grind at:
    http://www.writersdailygrind.blogspot.com.
    You can’t miss her!
    Anne G

  • Edward Haworth

    I think it was Plains of passage – I’m far from sure which one but I know I didn’t make it up!

  • Neziha

    The interesting thing about this to me is that to my knowledge Neanderthals were primarily carnivorous, which challenges assumptions about pigmentation evolution and diet.

  • Mememe

    Anne:
    “As well as in humans, red hair can be found in other mammalian species such as orangutans, squirrels, and highland cattle. Red hair or fur can be found in some breeds of dog and cat, and certain species of fox and deer.”
    Orangutan I believe it is a MC1R variant and they live close to the equator. Reality is Neanderthals could have brought this with them into Europe all the from Africa for all we know. There are several populations of humans who have red hair who are not “pale” and “blond” hair as well.

  • Junction

    “i assume the irish or something…”
    The Travellers, Aran Islands?

  • pconroy

    Junction,
    Growing up in Ireland I don’t ever remember seeing a red-headed Traveller, though many blonds and dirty-blonds.
    This site – based on some of Carleton Coon’s work – has some info on the Aran Islanders, especially that:
    The type is characterized by a great head length and an exceptionally low head height, a very long face and nose, and an excess of blue eyes and golden and red hair.
    and 2 photos:
    Aran Man, and Aran Youth

  • pconroy

    Aran Youth – profile view, seems to show him complete with Occipital Bun?!

  • Junction

    hawks has been talking about morphological overlap between moderns and neandertals for a while now….
    All modern humans or just “out of Africa” Asians and Europeans?
    They are still found fairly often among Basque, Lapp and Finn individuals. Bushmen from South Africa and Australian aborigines often have occipital buns also. A rare occurrence is found in the north of England where the occipital bun is widespread in south Lancashire.
    Could (Finns, etc.)the folks in south Lancashire also be modern neandertals?

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This blog is about evolution, genetics, genomics and their interstices. Please beware that comments are aggressively moderated. Uncivil or churlish comments will likely get you banned immediately, so make any contribution count!

About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com

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