Fat and tuberculosis

By Razib Khan | June 23, 2009 11:29 pm

Obesity May Have Offered Edge Over TB:

Over the course of human evolution, people with excess stores of fat have been more likely to survive famines, many scientists believe, living on to pass their genes to the next generation.
But these days, obesity is thought to be harmful, leading to chronic inflammation and metabolic disorders that set the stage for heart disease. So what went awry? When did excess fat stop being a protective mechanism that assured survival and instead become a liability?
A provocative new hypothesis suggests that in some people, fat not only stores energy but also revs up the body’s immune system. This subgroup may have enjoyed a survival advantage in the 1800s, when people were plagued by a disease that decimated Europe: tuberculosis.

The original paper is here. I’m skeptical, but I’d like people who know more about the history and distribution of tuberculosis to weigh in. My working assumption is that excess fat was helpful in most pre-modern contexts (i.e., female fertility) and obesity wasn’t common and simply a modern overshoot.

CATEGORIZED UNDER: Evolution, Health
  • bioIgnoramus

    “Overweight” seems to be the best band for life expectancy, which makes me wonder what evidence can possibly exist to justify the “over” prefix.

NEW ON DISCOVER
OPEN
CITIZEN SCIENCE
ADVERTISEMENT

Discover's Newsletter

Sign up to get the latest science news delivered weekly right to your inbox!

Gene Expression

This blog is about evolution, genetics, genomics and their interstices. Please beware that comments are aggressively moderated. Uncivil or churlish comments will likely get you banned immediately, so make any contribution count!

About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com

ADVERTISEMENT

See More

ADVERTISEMENT

RSS Razib’s Pinboard

Edifying books

Collapse bottom bar
+

Login to your Account

X
E-mail address:
Password:
Remember me
Forgot your password?
No problem. Click here to have it e-mailed to you.

Not Registered Yet?

Register now for FREE. Registration only takes a few minutes to complete. Register now »