Show me the data

By Razib Khan | January 26, 2010 4:16 pm

Update: Also see p-ter at Gene Expression Classic.
Follow up on
yesterday’s post on the new Dickson et al. paper from David Goldstein’s lab, A New Way to Look for Diseases’ Genetic Roots:

The Icelandic gene-hunting firm deCODE genetics, which emerged last week from bankruptcy, has long led in detecting SNPs associated with common disease. Dr. Kari Stefansson, the company’s founder and research director, agreed that whole genome sequencing would “give us a lot of extremely exciting data.” But he disputed Dr. Goldstein’s view that rare variants carried most of the missing heritability. Both deCODE genetics and scientists at the Broad Institute in Cambridge, Mass., have sequenced regions of the genome surrounding SNPs in search of rare variants, but have found very few, Dr. Stefansson said.
“We can speculate till we are blue in our faces,” he said, “but the fact of the matter is that there is no substitute for data.”

It would have been nice to get a quote from someone whose recent career hasn’t been as checkered as Stefansson. The issue of missing heritability is going to be interesting in the near future….


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About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at


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