Daily Data Dump – Friday

By Razib Khan | August 27, 2010 1:00 pm

Have a good weekend.

The ratio of human X chromosome to autosome diversity is positively correlated with genetic distance from genes. This is in my RSS, but not on the Nature site, so here’s the snip I have: “The ratio of X-linked to autosomal diversity was estimated from an analysis of six human genome sequences and found to deviate from the expected value of 0.75. However, the direction of this deviation depends on whether a particular sequence is close to or far from the nearest gene. This pattern may be explained by stronger locally acting selection on X-linked genes compared with autosomal genes, combined with larger effective population sizes for females than for males.” Looks interesting.

Journal: Hauser fabricated data. Scientists can be “too big fail” it seems.

Epistasis: Obstacle or Advantage for Mapping Complex Traits? They argue that it’s an advantage, and you can squeeze more juice by taking into account gene-gene interactions.

Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. There’s a model that unexpected deaths from infections which should be benign or asymptomatic are actually due to genetic variation. Specifically, these deaths run in families. Was there a time when everyone was symptomatic? It seems that this is a case where looking at indigenous populations who haven’t been as exposed to pathogens would be of interest.

Does Your Language Shape How You Think? It seems more a matter of degree if so.

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Comments (6)

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  1. Anonymous | August 27, 2010
  1. The word to “” has a nasty habit of escaping quotation marks.

  2. bioIgnoramus

    “Hauser will teach … Psychology E-1006: “The Moral Sense: From Genes to Law” in the spring.”
    Now you’re just being silly.

  3. bioIgnoramus

    ““Without knowing the exact specifics of the case, what I would say is if you want to chase someone out of the field forever, that doesn’t seem like the right idea,” said Michael S. Landy…”That’s just hurting that person and the field. Seems to me that there has to be a middle ground.””

    Mr Landy, I fart in your general direction.

  4. bioIgnoramus

    “Research and teaching are my passion,” Hauser said in the statement.
    And fabricating data. Three things: research, teaching and fabricating data.
    And expressing pious sentiments. Four things: research, teaching, fabricating data, and expressing pious sentiments. ………….

  5. J.J.E.

    By pure chance I ran into Hammer today. He had the preprint. It seems like for the most distant categories of genes the X and Autosomes were indistinguishable from one another whereas the closer regions showed the X having lower diversity.

    So, as I understand it, they are leaning towards interpreting those distal regions as being more representative of “neutrality” and the more proximal regions being influenced by purifying selection or selective sweeps, thereby decreasing diversity. The implication is that the ratio isn’t the simple 3/4 you’d get if males and females had the same reproductive success. Instead, you get the X having more diversity than you’d expect by that model, perhaps because famales have a lower variance in mating success than males.

    Oh, and since the X is more influenced than the autosomes by loss of diversity due to selection, many of the variants (either +ive or -ive) are likely to be recessive.


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About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com


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