History and Geography of Genes on a Desktop

By Razib Khan | October 25, 2010 10:14 am

In case you don’t know, Dienekes Pontikos has been posting a lot of analyses of available population genetic data sets with the ADMIXTURE program. You can find his myriad posts under the ADMIXTURE-experiments tag. Below is a bar plot he generated today. To follow up a debate which occurred last spring, it does seem from several of his results that there is some evidence of Berber admixture among the Sephardic Jews.

ADMIXTURE10

CATEGORIZED UNDER: Anthroplogy, Genetics
MORE ABOUT: Admixture, Genetics
  • onur

    To follow up a debate which occurred last spring, it does seem from several of his results that there is some evidence of Berber admixture among the Sephardic Jews.

    Doesn’t necessarily follow. It might also be from Egypt, or a result of the fact that the original Jews were geographically close to Egypt, or a combination of the possibilities.

  • http://blogs.discovermagazine.com/gnxp Razib Khan

    some evidence != necessarily follow

  • Antonio

    I am surprised about the admixtures among Utah Whites. I would expect more northern Europe component and nothing from Asia. Does it make sense? Actually, I think I never fully understood the meaning of Utah Whites in these studies, what is the deal with such group :)

  • JL

    Is the East Asian component in Utah whites actually Amerindian?

  • onur

    some evidence != necessarily follow

    Of course. I completely understand your logic. After all, even weak evidence is called “evidence”, no matter how weak it is.

  • http://blogs.discovermagazine.com/gnxp Razib Khan

    the berber admixture model is more parsimonious than the others. and since you like to assert the obvious as if it’s an interesting point, of course that does not entail that it is correct. but one can not dismiss it out of hand.

  • pconroy

    JL,

    I would think that the slight East Asian admixture in Utah Whites is just that, and not Amerindian. As a similar study carried out by Polako/Davidski shows that among others, some Irish people carry a slight amount of East Asian admixture, as well as slight Amerindian admixture – these are people who are 100% Irish, not American Whites.

    Here is the Global K=10 Ireland results.

  • onur

    Conroy, as Dienekes pointed out, methodology is very important. From the apparent differences in their results, it seems to me that Dienekes and Polako are using different methodologies. So it is hard to make inference about Dienekes’ results based on Polako’s results.

  • pconroy

    Onur,
    His methodology is here: Eurogenes 500K BGA Project

    Read it for yourself.

    The main difference I see is that they choose different reference populations, and that will alter results accordingly.

  • onur

    The main difference I see is that they choose different reference populations, and that will alter results accordingly.

    As I have explained many times on Dienekes’ blog, choosing reference populations are a very significant part of the methodology in every population genetics analysis. So it is of utmost importance to choose them very carefully.

  • onur

    Typo correction for “choosing reference populations arein comment #10: choosing reference populations is

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This blog is about evolution, genetics, genomics and their interstices. Please beware that comments are aggressively moderated. Uncivil or churlish comments will likely get you banned immediately, so make any contribution count!

About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com

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