Synthetic associations and all that

By Razib Khan | January 18, 2011 2:28 pm

PLoS Biology has four items of great interest out today:

– Synthetic Associations Created by Rare Variants Do Not Explain Most GWAS Results
– Synthetic Associations Are Unlikely to Account for Many Common Disease Genome-Wide Association Signals
– The Importance of Synthetic Associations Will Only Be Resolved Empirically
– Common Disease: Are Causative Alleles Common or Rare?

These are a response to last year’s paper on synthetic associations from the Goldstein lab. Here’s a critique of that that paper. I plan on reviewing the first in the list above soon. #3 is a response to #1 and #2 from David Goldstein, while #4 is a summation more aimed at the general audience.

CATEGORIZED UNDER: Genetics, Genomics
  • John Smith

    “Here’s a critique of that critique of that paper” – made me expect a critique of a critique! :D
    Very useful entry regardless!

  • razib

    Tx. Was hurrying 2 doctor’s appointment.

  • http://www.wired.com/wiredscience/geneticfuture/ Daniel MacArthur

    Worth noting that one of the critiques was lead by two members of Genomes Unzipped (Jeff Barrett and Carl Anderson) – I’m led to believe they’re writing a blog post about this that should go live tomorrow.

  • http://blogs.discovermagazine.com/gnxp Razib Khan

    yeah, i figured.

  • Pingback: The rise of genetic architecture | Gene Expression | Discover Magazine()

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This blog is about evolution, genetics, genomics and their interstices. Please beware that comments are aggressively moderated. Uncivil or churlish comments will likely get you banned immediately, so make any contribution count!

About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com

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