Mediterranean men on the move

By Razib Khan | May 31, 2011 3:06 pm

ResearchBlogging.orgSeriously, sometimes history matches fiction a lot more than we’d have expected, or wished. In the early 2000s the Oxford geneticist Bryan Sykes observed a pattern of discordance between the spatial distribution of male mediated ancestry on the nonrecombinant Y chromosome (NRY) and female mediated ancestry in the mitochondrial DNA (mtDNA). To explains this he offered a somewhat sensationalist narrative to the press about possible repeated instances of male genocide against lineage groups who lost in conflicts.

Here is a portion of the book of Numbers in the Bible:

15 – And Moses said unto them, Have ye saved all the women alive?

16 – Behold, these caused the children of Israel, through the counsel of Balaam, to commit trespass against the LORD in the matter of Peor, and there was a plague among the congregation of the LORD.

17 – Now therefore kill every male among the little ones, and kill every woman that hath known man by lying with him.

18 – But all the women children, that have not known a man by lying with him, keep alive for yourselves.

Then there is the rape of the Sabine women. The ethnogenesis of the mestizo and mulatto populations of the New World in large part was the union between non-European women and European men. These are hard brutal myths and hard brutal facts. But do they reflect an essential aspect of the dynamics which have shaped our species’ past?

I’m not willing quite yet to add a confident weight upon this possibility, but this seems to be part at least part of the picture. You see a major disjunction on male and female lineages among South Asians for example. A new paper in PNAS adds weight to this possibility, albeit only incrementally. Ancient DNA reveals male diffusion through the Neolithic Mediterranean route:

The Neolithic is a key period in the history of the European settlement. Although archaeological and present-day genetic data suggest several hypotheses regarding the human migration patterns at this period, validation of these hypotheses with the use of ancient genetic data has been limited. In this context, we studied DNA extracted from 53 individuals buried in a necropolis used by a French local community 5,000 y ago. The relatively good DNA preservation of the samples allowed us to obtain autosomal, Y-chromosomal, and/or mtDNA data for 29 of the 53 samples studied. From these datasets, we established close parental relationships within the necropolis and determined maternal and paternal lineages as well as the absence of an allele associated with lactase persistence, probably carried by Neolithic cultures of central Europe. Our study provides an integrative view of the genetic past in southern France at the end of the Neolithic period. Furthermore, the Y-haplotype lineages characterized and the study of their current repartition in European populations confirm a greater influence of the Mediterranean than the Central European route in the peopling of southern Europe during the Neolithic transition.

First, the easy stuff. This is another datum which should make us skeptical of the idea of Neolithicization as an overwhelmingly indigenous process, spreading via cultural emulation. The Y chromosomal lineages sequenced here are very homogeneous, and seem to belong to a patrilocal kinship group. In contrast, the mtDNA lineages, which tell us about female ancestry, are much more diverse. They cover a much better sweep of contemporary European genetic diversity. The authors note that a minority of mtDNA lineages are of Middle Eastern origin, but the majority are of lineages which are presumed to have a deeper Paleolithic root, as supported by their greater variance. I think we should still be cautious of even this interpretation, but there does seem to be a notable difference in this one community between males and females which may be indicative of a particular social and cultural system.

The maps to the left show the relationship of mtDNA and Y lineages to modern patterns of European genetic variation. The darker the shading the higher proportion of lineages shared. The top figure illustrates female mtDNA, and you can see the broad correspondences between the ancient southwest French sample and modern groups. But observe the big difference in the second figure, which shows the male distributions. This is much more localized to particular regions of Iberia and Turkey. The overwhelming haplogroup in the cemetery was G2a-P15, which is rather rare in Europe today, and the region. What happened to these men? Genetic drift or population replacement perhaps. If one posits a model of long term smaller male effective populations then Y chromosomal lineages will be subject to more stochastic extinction and fixation events than mtDNA. I’m not sure if I believe this, but that is one model which doesn’t necessarily involve a conventional replacement of the male lineages a la Conan.

But the dispersal of G2a-P15 at low frequencies around the Mediterranean is also consistent with the possibility of repeated replacement of male lineages across the arc of history. This has historical precedent, the Greek colonies alonge fringes of  the Mediterranean were founded by men, sometimes explicitly exiled from their home polis. They had often had to “obtain” local women to perpetuate themselves. This isn’t supposition or conjecture, but outlined in some of the texts which record how colonies were founded in the Archaic pre-Classical period. Of course we do know that these sorts of transplantations could also involve women, they seem to have in the case of the Etruscans.

Additionally, this may also be a case of male “leap-frog” migration patterns, which break apart the null model of genetic variation which is modeled by isolation-by-distance. The argument is that the expansion of farming from the eastern Mediterranean did not occur via demic diffusion by land, but rather through a process of maritime transplantation, and then subsequent expansion from the nascent nuclei. Again, we can look at the expansion of the maritime Greeks. There was no contiguous region of Greek settlement between Greece proper and “Magna Graecia” in southern Italy and Sicily. Connections were by sea, which makes sense insofar as long distance sea transport was far cheaper energetically than land migration. I see no reason why these ancient farming Diasporas couldn’t have maintained a sort of cultural continuity for centuries through ritual or regular contacts via maritime transit.

A second point in this paper is that this population seems to have lacked in totality the allele which is diagnostic of lactase persistence across much of Europe today. The authors observe that that allele has a frequency of ~43% in the modern French population (it’s dominant, so that means that ~35% of the French are lactose intolerance). I would be curious about the frequency in the south of France, as traditionally the north of France was the domain of butter, while that to the south more of olive oil (historically the south of France witnessed the preservation of the Gallo-Roman aristocracy, which explicitly adopted Frankish modes of dress in 5th century as a way to assimilate into the non-clerical administrative apparatus of the Merovingian monarchy, but maintained their cultural distinction). The authors conclude from the lack of the LP allele that the individuals buried in the cemetery were from a different migration stream than those which founded the LBK society in central Europe, and who may have invented the dairy culture.

I think the “big picture” that is shaping up is that there were multiple intrusions, eruptions, replacements, and assimilations, across prehistoric Europe, just as there were across many regions of the world. On the whole I suspect males played more of a role in this process than females, though I’m not confident that we will see a consistent pattern of female lineages in a given area being markers for the Paleolithic populations. There may have been so much shifting and layering that the original people, the oldest of old, may only be accessible via ancient DNA. Speaking of which, thank god we’re finally entering the golden age of ancient DNA! Many questions will no doubt finally be resolved.

Dienekes Pontikos also has a lot to say about this. I’m sure some of you who are more versed in mtDNA and NRY haplogroups will also offer you 2 cents!

Citation: Marie Lacan, Christine Keyser, François-Xavier Ricaut, Nicolas Brucato, Francis Duranthon, Jean Guilaine, Eric Crubézy, & Bertrand Ludes (2011). Ancient DNA reveals male diffusion through the Neolithic Mediterranean route PNAS : 10.1073/pnas.1100723108

CATEGORIZED UNDER: Anthroplogy, Genetics, Genomics
  • Gary B

    I happened to be thinking of something closely related to this yesterday, with the observation that conquering armies have historically very often seeded the conquered population with their own, presumably more ‘fit’ genes, while also generally reducing or eliminating the males of the losing population. This seems to me to be an effective mechanism for ‘improving’ the gene pool of the conquered population – in the sole sense of having succeeded in that environment! (As a desk jockey I like to think I have a certain type of fitness that does not express well in that environment, but does have its merits.)

    Since similar behaviors have been seen in various primates (and, IIRC some other mammals and perhaps non-mammals) it seems to be a social extrapolation of a behavior related to evolutionary fitness.

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  • http://www.buildinghistory.org/distantpast/ Jean M

    Bryan Sykes heavily invested, both academically and commercially, in his vision of The Seven Daughters of Eve (2001) – the matriarchs of the European population, only one of whom (Jasmine i.e. mtDNA J) he pictured as arriving from the Near East with farming. The rest he saw as more ancient in Europe.

    Unfortunately for Sykes, he was just plain wrong. Now that aDNA researchers have better techniques to guard against contamination, and can test to a much higher degree of resolution on the mtDNA tree, the picture has turned completely around. Two papers last year showed that Neolithic people in Northern Europe were completely unrelated to their Mesolithic predecessors, who were overwhelmingly U4 and U5. It no longer looks as though H1 and H3 were spread from the Franco-Cantabrian refuge either. See my blog post: Franco-Cantabrian refuge for what? Not mtDNA H1, H3.

    New papers attempting to set their own material in context do not always reflect the latest discoveries. There is often a long delay between submission and publication of a paper. This is the second paper which has attempted to reconcile the old Sykes story with what is emerging from Y-DNA, not realizing that the Seven Daughters saga has gone the way of the dodo.

    Some of the mtDNA haplogroups found in this study are indeed ancient in Europe – the U5 for sure. But not the majority.

  • http://dioegenesartemis.blogspot.com/ Diogenes

    This data makes everything even more interesting.
    Absence of J2 and E1b1b fits rather well with their possible expansion with Semitic only after 3000BC in the Near East (and later in Europe).
    This cave could well be a family graveyard. Some individuals appear to be closely related. So uniformity in Y-DNA haplogroups is not so surprising.
    Supposing it is representative, lack of much G in Europe nowdays, combined with some G in peripheral LBK found before, and lack of R in the sample, may mean that several waves with major demographic impact made their way to Europe, which I think lends more support to complete replacement models. Higher forager-associated mtDNA haplogroups (like U5b) than today could also be explained by such a model.

    Absence of R1b may be due to their presence elsewhere, such as in major river valley settlements colonised earlier, and in possible hybridised forager and semi-forager populations. So “late foragers” may actually turn out to have plenty R1b (if late foragers are found with some R1b as I think it’s likely, it’ll be interesting to see what people will say). New arrivals such as some secondary waves may have had enough agricultural advantages to have a bigger demographic impact in less fertile regions left fallow by earlier waves.
    R1b could then regain ground if it was based in the richer areas, which upon acquiring innovations, would due to higher density and surplus be natural elite-formation centres for less fertile regions over several millennia. These events wouldn’t necessarily imply major autossomal changes or discontinuity. Patriarchal societies would tend to transmit Y-DNA (prestige of uniterrupted male lines to elites) but not so much autossomes.
    Greater amounts of forager-associated mtDNA than found today also can be explained by Treilles being a new settlement by a new Near Eastern wave, in a previously fallow area.

  • melqart

    I can’t make the farmer/forager dichotomy fit very well with many of the places where I think I know a bit about the prehistory – for instance, of the much more complex farmer/forager/herdsman trichotomy in the middle east; or the corn and kitchen garden hunter-foragers of North America.

  • http://washparkprophet.blogspot.com ohwilleke

    One doesn’t need a full on Book of Numbers scenario to get the result.

    One can simply have a scenario in which farming disrupts the viability of hunter-gathering by disrupting the local ecology enough to make most people who adhere to that approach die of starvation or dramatically decline in numbers due to factors like infant mortality increases or farm culture disease, and to have a minority of women taken as brides (at least some of the time in arrangements as voluntarily as would be the case with couples within hunter-gatherer society) who leave legacies. The new wave doesn’t have to be the direct warlike means of slaughter of the men. Indeed, it is hard to believe that warlike slaughter could have been that completely successful at that relatively rudimentary level of military prowess.

    There might have been selective slaughter’s of men, but exile to marginal hunting and foraging areas seems more plausibe as the main basis for the marginalization of the Y-DNA of members of the hunter-foraging societies.

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This blog is about evolution, genetics, genomics and their interstices. Please beware that comments are aggressively moderated. Uncivil or churlish comments will likely get you banned immediately, so make any contribution count!

About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com

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