Beware of scientific revolutions!

By Razib Khan | August 28, 2011 12:15 am

Above is the Ngram result for paradigm shift, a ubiquitous descriptive concept which can be quite slippery when applied to contemporary science. For example, every few years there is always a new “revolution” which is going to overturn “Darwinism.” Be it punctuated equilibrium, symbiogenesis, or epigenetics. But over time revolutionary fervor abates, and the orthodoxy remains standing, albeit with modifications and alterations, making it all the more robust.

I thought of this when I saw Andrea Cantor’s comment below in relation to twin studies:

Twin studies underestimate heritability only if you subscribe to the crude notion that the effect of genes is additive, i.e., keeping “environments” the same, the more similar two people are genetically the more alike they will be. This ignores everything we now know about the way genes work.

Genes are not self-activating: they do not turn themselves on and produce traits. Genes do not, in fact, produce anything. Genes are turned on and off by the epigenome in response to environmental inputs. If you are inclined to doubt this, then consider: If all the cells in our body are supposed to contain identical DNA, how do you account for the existence of different tissues and cells types (answer: the epigenome). Twins have been shown to have significantly different epigenomes in the womb. Does this show that twin studies underestimate heritability? Of course not. It shows, rather, that these studies are out of touch with advances in molecular genetics.

You are all committed to a crude, 19th century conception of the relationship between genotype and phenotype. Twin studies are based upon a scientific paradigm that has remained unchanged since the time of Galton. Problem is, recent advances in molecular genetics are bringing about a paradigm shift in the science of genetics.

Twin studies make it seem all so easy: All you need is a large data set that has zygosity status and statistical software and any undergraduate can unravel the biomolecular basis of human behavior.
Would that it were so easy.


I get comments like this frequently. Often I don’t publish them (in fact, I usually ban the commenter). These contributions to the discussion exhibit internal coherency, and thankfully they’re not personal attacks (though they do tend to stink of condescension). But they don’t really further the discussion, and are liable to just confuse people. I let this comment through because I thought it might be interesting to respond to it, to clarify a few points.

I highlighted some buzzwords and tendencies which unify a broad range of commenters/opinionators on science, from Creationists to quasi-Blank Slaters. There are general terms such as “paradigm shift.” There are almost always references to how dated the science that you are alluding to is. You are “out of touch” (or being perverse). Then there are the weird “what does that even mean?” assertions which often litter this class of comments. This is probably the main reason I often don’t let these comments through: they waste your time because they require a lot of interpretation. I honestly don’t know what it means to assert that anyone would think that twin studies can unravel the “biomolecular basis of human behavior.” I’d like to meet the person who thinks this. Finally, there are the specific buzzwords. Here you have epigenome. A reference to the mysterious connection between genotype and phenotype usually helps to impress as well.

But it turns out that I didn’t even need to respond. Luke Jostins is at it again, defending the honor of the twin study! Here’s his comment:

@Andrea Cantor

The relationship between biological interaction and genetic addativity on the variance component scale is more complex than I think you realise, and the common terms between the two (additivity, interaction, etc) seem to have thrown off your intuition. The fact is that virtually all the assumptions of twin studies have been extensively tested, and they have all been found to be relatively good approximations (statistically) the behaviour of genetic risk in populations, in certain relatively well characterised circumstances. This doesn’t mean that biological systems aren’t full of interaction, or that epigenetic effects are not important, or that genetic effects are stationary over time, or that interactions between genes and environment do not exist. It just means that your intuitive feel that these effects result in statistical non-additivity on the genetic risk scale is wrong.

In other words, Andrea Cantor doesn’t know what she’s talking about. That’s fine. But using her comment as a prototype, I hope it will help us navigate the turbulent waters of the scientific discourse.

CATEGORIZED UNDER: Behavior Genetics
MORE ABOUT: twin studies
  • Justin Giancola

    Symbiogenesis: wow, that’s pretty neat stuff; the full version of that idea was new to me. If it indeed applies to mitochondria, then why just?

  • John Emerson

    Thomas Kuhn hated the way his ideas were received even in the scientific and scholarly community, to say nothing of the general culture. He regretted that he had ever used the phrase “paradigm shift” or even the word “paradigm”.

    In 1999 one of the stupidest people I’ve ever known, a woman running the knicknack section of a bookstore, came in from a management in-service completely pumped about The Paradigm Shift To Excellence. That was the bottom. There’s nowhere to fall from there.

  • Darkseid

    i’m still, and always will be, a beginner but isn’t the epigenome inherited as well? otherwise, how would any gene ever get any directives at any time? it seems she’s mistaken and also very condescending and pretentious. that’s a good commenting policy, though. the more deleted comments there are tighter the discussion gets. a person like me may not realize she’s completely wrong and, thus, am getting bad info (indirectly) from this site and it also wastes everyone’s time and depletes your daily decision making energy for no reason.

  • ackbark

    Her tone reminds me of some kind of house style of something I cannot put my finger on.

    What is it?

  • observer

    The appeal to epigenetics as the “way out” from the often decisive impact of genetics is just one more rearguard action employing obfuscation as its primary weapon. As with the others, it takes a phenomenon of limited application and significance, and attempts to blow it up into an overarching account that explains everything inconvenient away.

    But it is based, of course, in ignorance — the ignorance of the obfuscator, and the hoped for ignorance in the audience.

  • Bob

    Well, it seems a shame to me: I suspect she’s (he’s?) non-stupid. I’m guessing she is in a group (Sociology department?) where they say this kind of thing to each other. It lets them enjoy a belief that they’re up on the latest science, while at the same time steering clear of anything conceivably racist. What a mess.
    Cheers,
    –Bob

  • DK

    This ignores everything everything we now know about the way genes work. Genes are not self-activating: they do not turn themselves on and produce traits. Genes do not, in fact, produce anything. Genes are turned on and off by the epigenome

    I stopped reading there. A person writing stuff like this cannot possibly say anything worthwhile reading on any subject even most tangentially related to genes.

  • biologist

    in the cases of epistasis, intuition is incorrect about it causing substantial non-additive variance

    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265475/
    “Data and Theory Point to Mainly Additive Genetic Variance for Complex Traits”

    Abstract: The relative proportion of additive and non-additive variation for complex traits is important in evolutionary biology, medicine, and agriculture. We address a long-standing controversy and paradox about the contribution of non-additive genetic variation, namely that knowledge about biological pathways and gene networks imply that epistasis is important. Yet empirical data across a range of traits and species imply that most genetic variance is additive. We evaluate the evidence from empirical studies of genetic variance components and find that additive variance typically accounts for over half, and often close to 100%, of the total genetic variance. We present new theoretical results, based upon the distribution of allele frequencies under neutral and other population genetic models, that show why this is the case even if there are non-additive effects at the level of gene action. We conclude that interactions at the level of genes are not likely to generate much interaction at the level of variance.

    if you take each of the suggested mechanisms one at a time you find basically the same conclusion. while these mechanisms are interesting biologically they do not contribute substantially to non-additive variance for most complex traits — at least according to the available evidence and theory.

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This blog is about evolution, genetics, genomics and their interstices. Please beware that comments are aggressively moderated. Uncivil or churlish comments will likely get you banned immediately, so make any contribution count!

About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com

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