How do relatives correlate in traits?

By Razib Khan | December 30, 2011 1:24 am The Pith: Even traits where most of the variation you see around you is controlled by genes still exhibit a lot of variation within families. That’s why there are siblings of very different heights or intellectual aptitudes.

In a post below I played fast and loose with the term correlation and caused some confusion. Correlation is obviously a set of precise statistical terms, but it also has a colloquial connotation. Additionally, I regularly talk about heritability. Heritability is in short the proportion of phenotypic variance which can be explained by genetic variance. In other words, if heritability is ~1 almost all the variation in the trait is due to variation in genes, while if heritability is ~0 almost none of it is. Correlation and heritability of traits across generations are obviously related, but they’re not the same.

This post is to clarify a few of these confusions, and sharpen some intuitions. Or perhaps more accurately, banish them.

The plot above shows relationship between heights of fathers and heights of sons in standard deviation units (yes, I removed some of the values!). You see that the slope is ~0.45, and that’s the correlation. At this point you probably know that heritability of height is on the order of 0.8-0.9. So why is the correlation so low? A simple biological reason is that you don’t know the value of the mothers. If the parents are not strongly correlated (assortative mating) obviously the values of the sons is going to diverge from that of the father. That being said, you probably notice that the correlation here is about 1/2 that of the heritability you know has been confirmed in the literature. That’s no coincidence. One way to estimate heritability is to take the slope of the plot of offspring vs. parents, and multiply that by 2. Therefore, the correlation (which equals the slope) is 1/2 × h2, where h2 represents heritability.

Correlation (parent to offspring) = 1/2 × h2

1/2 turns out to be the coefficient of relatedness of a parent to offspring. I’ll spare you the algebra, but suffice it to say that this is not a coincide. Where r = coefficient of relatedness the correlation between sets of relatives on a trait value is predicted to be:

Correlation (relative to relative) = r × h2

Where r is simply the coefficient of relatedness across the pair of relatives. Here are some values:

rrelationship
0.5 (½)parent-offspring
0.25 (¼)grandparent-grandchild
1identical twins; clones
0.5 (½)full siblings
0.25 (¼)half siblings
0.125 (⅛)first cousins

Here’s the kicker: the correlation coefficient of the midparent value and the offspring value does not equal the slope of the line of best fit. This is why I had second thoughts about using the term “correlation” so freely, and then switching to heritability. The formula is:

Correlation (midparent to offspring) = 1/√2 × h2

So the correlation of midparent to offspring is 0.71 × heritability.

Why is this something you might want to know? I think people are sometimes confused about how an extremely heritable trait, like height, where you’re given heritability values of 0.90, still yields families with such a wide range of heights. Well, recall that the coefficient of relatedness among siblings is 1/2. So their correlation is going to be the same as with parents. Therefore, the magnitude will be half that of the heritability. A correlation of 0.45 is not small, but neither is it extremely tight. The histogram below illustrates this with the above data set. The values are simply the real difference between fathers and sons: CATEGORIZED UNDER: Quantitative Genetics

1. Jonathan Campbell

“Here’s the kicker: the correlation coefficient of the midparent value and the offspring value does not equal the slope of the line of best fit. This is why I had second thoughts about using the term “correlation” so freely, and then switching to heritability. The formula is:
Correlation (midparent to offspring) = 1/√2 × h2”

The sqrt(2) factor seems to mating which is totally uncorrelated with respect to height (i.e. the opposite of assortative mating).

For example if mating were completely assortative (you only mated with someone of exact same normalized height), then surely the midparent value would have the same variance as the father (or mother) value alone, as well as of the child value (assuming constant variance across generations, which I know may not be totally true, but likely will be in a steady state), and thus slope = correlation. The sqrt(2) seems to be based on a dampened midparent variance (as compared to parent variance) which is a result of unassortative mating.

The reason it seems based on unassortative mating is that the standard deviation of the sum of 2 uncorrelated variables (each with the same sd) is sqrt(2) times the standard deviation of one of the variables. If the variables are correlated the factor be more than sqrt(2).

2. Razib Khan

The sqrt(2) seems to be based on a dampened midparent variance (as compared to parent variance) which is a result of unassortative mating.

yes.

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