Comments on: Loss-of-function & variation in load http://blogs.discovermagazine.com/gnxp/2012/02/loss-of-function-variation-in-load/ Mon, 20 May 2013 01:52:00 +0000 hourly 1 http://wordpress.org/?v=3.4.2 By: Roofus http://blogs.discovermagazine.com/gnxp/2012/02/loss-of-function-variation-in-load/#comment-40673 Roofus Thu, 23 Feb 2012 17:01:02 +0000 http://blogs.discovermagazine.com/gnxp/?p=15832#comment-40673 Do the calculations take into account the fact that the sibling rates are correlated? The distribution of a difference of independent Poissons is a Skeelen distribution which is probably close to a normal in your example. Siblings though should be correlated right? Do the calculations take into account the fact that the sibling rates are correlated? The distribution of a difference of independent Poissons is a Skeelen distribution which is probably close to a normal in your example. Siblings though should be correlated right?

]]> By: Razib Khan http://blogs.discovermagazine.com/gnxp/2012/02/loss-of-function-variation-in-load/#comment-40672 Razib Khan Wed, 22 Feb 2012 21:58:00 +0000 http://blogs.discovermagazine.com/gnxp/?p=15832#comment-40672 #1, low frequency event. my understanding is that usually in biology it *underestimates* variation. also, they might have the real distribution in their sample in the supps. didn't check. #1, low frequency event. my understanding is that usually in biology it *underestimates* variation. also, they might have the real distribution in their sample in the supps. didn’t check.

]]> By: Jacob Roberson http://blogs.discovermagazine.com/gnxp/2012/02/loss-of-function-variation-in-load/#comment-40671 Jacob Roberson Wed, 22 Feb 2012 17:33:09 +0000 http://blogs.discovermagazine.com/gnxp/?p=15832#comment-40671 <i>poisson</i> I don't trust WP, so to verify: Poisson is used for mutations _____. A) Usually, general case? B) In studies like this, because they cast a wide net? C) ? poisson

I don’t trust WP, so to verify: Poisson is used for mutations _____.

A) Usually, general case?
B) In studies like this, because they cast a wide net?
C) ?

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