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	<title>Comments on: DNA Replication</title>
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	<link>http://blogs.discovermagazine.com/gnxp/2012/04/dna-replication/</link>
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		<title>By: Discovering</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/04/dna-replication/#comment-41636</link>
		<dc:creator>Discovering</dc:creator>
		<pubDate>Mon, 16 Apr 2012 23:19:03 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=16247#comment-41636</guid>
		<description>three.Feasibility: analysis around how reasonable the specifications are in phrases of energy, time, charges.</description>
		<content:encoded><![CDATA[<p>three.Feasibility: analysis around how reasonable the specifications are in phrases of energy, time, charges.</p>
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		<title>By: TGGP</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/04/dna-replication/#comment-41635</link>
		<dc:creator>TGGP</dc:creator>
		<pubDate>Thu, 12 Apr 2012 05:48:11 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=16247#comment-41635</guid>
		<description>The video was new to me. Thanks.</description>
		<content:encoded><![CDATA[<p>The video was new to me. Thanks.</p>
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		<title>By: Evan Guiney</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/04/dna-replication/#comment-41634</link>
		<dc:creator>Evan Guiney</dc:creator>
		<pubDate>Wed, 11 Apr 2012 19:09:09 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=16247#comment-41634</guid>
		<description>@ Chris

There&#039;s a really good reason the lagging strand has to be done in such a weird backward fashion, rather than allowing DNA to be polymerized &#039;in both directions&#039;; its proofreading. As the polymerase moves along, it sometimes incorporates an incorrect base, and usually catches itself and removes the improperly paired base. It can then try again, and almost always adds the correct letter. (this in itself if insanely awesome.)

But a polymerase that evolved to elongate &quot;backwards&quot; wouldn&#039;t have this proofreading option, because of the chemistry of the DNA backbone. Chew backwards from the growing end of a DNA strand, and you are always left with a reactive oxygen exposed to add the next base to. But from the other direction, if you chew away, you leave an unreactive phosphate group, to which no further bases can be added. So DNA can only grow in one direction!</description>
		<content:encoded><![CDATA[<p>@ Chris</p>
<p>There&#8217;s a really good reason the lagging strand has to be done in such a weird backward fashion, rather than allowing DNA to be polymerized &#8216;in both directions&#8217;; its proofreading. As the polymerase moves along, it sometimes incorporates an incorrect base, and usually catches itself and removes the improperly paired base. It can then try again, and almost always adds the correct letter. (this in itself if insanely awesome.)</p>
<p>But a polymerase that evolved to elongate &#8220;backwards&#8221; wouldn&#8217;t have this proofreading option, because of the chemistry of the DNA backbone. Chew backwards from the growing end of a DNA strand, and you are always left with a reactive oxygen exposed to add the next base to. But from the other direction, if you chew away, you leave an unreactive phosphate group, to which no further bases can be added. So DNA can only grow in one direction!</p>
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		<title>By: Chris</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/04/dna-replication/#comment-41633</link>
		<dc:creator>Chris</dc:creator>
		<pubDate>Tue, 10 Apr 2012 15:33:28 +0000</pubDate>
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		<description>Simply amazing on two fronts.  That this is happening all the time in our bodies and the fact that we can actually show how this is working.  Although I always wondered why that second strand has to be put together in such an odd fashion.  You&#039;d think it&#039;d be pretty easy to evolve helicase to do one forward and backward rather than twisting the DNA around.</description>
		<content:encoded><![CDATA[<p>Simply amazing on two fronts.  That this is happening all the time in our bodies and the fact that we can actually show how this is working.  Although I always wondered why that second strand has to be put together in such an odd fashion.  You&#8217;d think it&#8217;d be pretty easy to evolve helicase to do one forward and backward rather than twisting the DNA around.</p>
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		<title>By: nyblackatheist</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/04/dna-replication/#comment-41632</link>
		<dc:creator>nyblackatheist</dc:creator>
		<pubDate>Tue, 10 Apr 2012 15:01:43 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=16247#comment-41632</guid>
		<description>DNA replication leads to genetic mutation.An imperfect process means there is no perfect designer. freethoughthiphop.com</description>
		<content:encoded><![CDATA[<p>DNA replication leads to genetic mutation.An imperfect process means there is no perfect designer. freethoughthiphop.com</p>
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		<title>By: Darkseid</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/04/dna-replication/#comment-41631</link>
		<dc:creator>Darkseid</dc:creator>
		<pubDate>Tue, 10 Apr 2012 12:21:17 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=16247#comment-41631</guid>
		<description>I&#039;m as godless as they come but whenever I see this clip its difficult to not ask yourself certain questions.  What an amazing process.</description>
		<content:encoded><![CDATA[<p>I&#8217;m as godless as they come but whenever I see this clip its difficult to not ask yourself certain questions.  What an amazing process.</p>
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