Comments on: The world is as it should be in personal genomics

By: Mark Adams

Mark Adams — Sat, 28 Apr 2012 09:40:38 +0000

Runs of homozygosity (ROH) are also informative of inbreeding and can be applied usefully to individuals. See Kirin et al http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0013996

By: Anthony

Anthony — Thu, 26 Apr 2012 15:03:56 +0000

Razib – is there data as to the standard deviation of the contributions of the ancestors?

By: Razib Khan

Razib Khan — Thu, 26 Apr 2012 00:33:55 +0000

#5, expected value is 0.25. and, you know that for the autosome:

paternal grandfather + paternal grandmother = 0.5, and the same for maternal.

By: Hassan

Hassan — Thu, 26 Apr 2012 00:21:48 +0000

Razib, this might sound ignorant/stupid of me. But is there any formal research that shows what the average contributions by each grandparent (the average of paternal grandfather, maternal grandmother’s, etc.)?

Should I expect a person to generally have paternal grandfather > paternal grandmother and maternal grandmother >maternal grandfather?

By: Razib Khan

Razib Khan — Wed, 25 Apr 2012 01:52:06 +0000

henry, the authors of plink assume you’re doing GWAS. so they think you’re looking for a very homogeneous population with about equal relatedness. with that in mind, i think they mean to imply that negative F would be a sample you didn’t want your study.

By: Henry Harpending

Henry Harpending — Wed, 25 Apr 2012 01:49:04 +0000

Razib a negative F does not necessariy nor even likely represent sample contamination. It is simply the genetic covariance between parents (always relative to some base population.) If the genetic covariance between the parents is negative then the child is (relatively) outbred and F is negative.

Kinship and inbreeding coefficients are much more general than the pedigree calculations one learns in intro genetics.

Good looking child by the way. Congrats.

Henry

By: Ed

Ed — Tue, 24 Apr 2012 18:11:19 +0000

Very interesting. I didn’t know that the contributions would vary by paternal/maternal grandfathers and grandmothers.

By: Nihaya Khateb

Nihaya Khateb — Tue, 24 Apr 2012 17:01:59 +0000

Razib, I will follow your posts until your daughter reaches the age of adolecent. It’s interesting for me to know how will you then analize her behavior? would you find out that part of her behavior is paternal and the other part is maternal? and when you will have another children: who would have mor parts of your brain and who will have more parts of maternal brain? I have read your comparing of behavior between your brothers, and I liked your conclusions because thy resemble mine.But I think that we inherit our brain structure exactly like the way we inherit any other organ. Our behavior depends basicly on the structure of our brain that we inherited from our parents. Because of the complicated function of the brain, scientists do’nt beleive in this idea of mine. I hope that you someday will be convinced with my model for I rely on your observations.