The bell curve of personality?

By Razib Khan | May 9, 2012 11:27 pm

I stopped reading much in the area of personality and behavior genetics a few years back. The main reason is I had a really hard time believing there were very good quantitative measures of many of the traits. A secondary issue, though probably nearly as important, is that some friends were making it clear that they strongly suspected that a lot of the studies in the area of behavior genomics were “underpowered” in a statistical sense. These two issues gnawed at me to the point where I pretty much threw my hands up in the air. Mind you, I accept that personality is substantially heritable. But just because something is heritable does not mean that it is obvious that you’ll be able to detect “the gene” implicated in the variation of the trait. I accepted decades of findings in behavior genetics. But it didn’t seem like we were going anywhere beyond it.

Now a new paper out in PNAS uses genomics to shed light on this issue in the same manner as with intelligence or height. The paper is The genetic architecture of economic and political preferences, and it is free to all. The two primaries takeaways are:

- Yes, variations in traits like political ideology can be attributed in part due to variations in genes.

- These variations in genes are likely widely distributed and dispersed across the genome, so that it is probably unwise to speak of the “conservative” or “liberal” gene. Rather, like height and I.Q. one can imagine political and economic preferences as a continuous trait under polygenic influence.

On the one hand confirmation of the partially genetic nature of the variation of even complex behavioral and cogntivie traits should lend some credence to some of the arguments in works such as The Republican Brain and The Righteous Mind (as well as my friend David Dobbs’ forthcoming book on behavior genetics and personality). But it also makes science communication very difficult, because when people hear about genetics, they want to know about the specific and concrete gene. This is a game where molecular geneticists have a great advantage over quantitative or population geneticists, because their gene is far less an abstraction. Because heritable variation in personality is at some remove from our “common sense,” much of the public is ignorant or rejects the very idea. Unfortunately, the rest of the public which is open to heritable variation tend toward rather crude hereditarian models.

Of course there may come in a day in the future when the genes for illnesses like social anxiety disorder are well characterized (or more accurately in all likelihood, the genomic regions which are responsible for the variation, as there will be many). But that day is not this day. A paper such as the one above makes us more confident that the genes do exist, but it also tells us that finding those genes is going to be more difficult than we imagined.

CATEGORIZED UNDER: Behavior Genetics
MORE ABOUT: Behavior Genetics
  • http://emilkirkegaard.com Emil

    When i first read the title of this post, i was expecting u to talk about a single factor of personality. Some researchers think that the personality traits can be reduced to a single factor. Presumably becus the different traits correlate in some way. Example paper: http://www.sciencedirect.com/science/article/pii/S0092656607000256

    Btw Razib, is there any reason that u use “NetworkedBlogs”? It has the annoying feature of adding an overlay (or whatever to call it) when i click the links from Facebook. Any chance u can get rid of this?

  • http://neuroskeptic.blogspot.com Neuroskeptic

    “But it also makes science communication very difficult, because when people hear about genetics, they want to know about the specific and concrete gene”

    Exactly. I’m not sure anyone’s worked out a way of communicating “the gist of” highly multigenic variation yet. But nothing in science communication is impossible …

  • http://blogs.discovermagazine.com/gnxp Razib Khan

    #3, what should i use?

  • chris w

    How do they control for or estimate environmental differences in these GWAS studies?

  • http://blogs.discovermagazine.com/gnxp Razib Khan

    #4, depends on GWAS study. some traits aren’t much enviro (think medical). but you would need to control for background variables in something like a cognitive phenotype. make sure you get a homogeneous population. or you can do some statistical trickery to control for the effect of environment after the fact in some model.

  • http://theunsilencedscience.blogspot.com/ nooffensebut

    “I stopped reading much in the area of personality and behavior genetics a few years back.”

    It is unfortunate that you would blithely disregard so much science as bad science, as the evidence—particularly for the warrior gene—keeps piling up. After hundreds of studies on the gene, its mRNA, its enzyme, its metabolites, its epigenetics, its epistasis and corroborating lines of evidence with different ages, different populations, promoter-effect animal models, knock-out-gene animal models, different-allele dose responses, brain imaging, and so forth, maybe the collective body of research has accumulated a sample size worthy of attention.

  • http://blogs.discovermagazine.com/gnxp Razib Khan

    It is unfortunate that you would blithely disregard so much science as bad science,

    where the fuck did i say it was ‘bad science’? don’t put words into my mouth again. EVER. even if you have social retardation syndrome i assume you understand what i’m getting at.

  • Nihaya Khateb

    I have a new-old model for evolutionary behavior. I am going to speak about it in Ottawa congress this summer. I could not tell my idea now, but I can tell you that science un general and behavior in particular, could not reach it’s reality without connecting to intouition and to the street’ real life.

  • http://blogs.discovermagazine.com/gnxp Razib Khan

    #8, that’s a really bizarre comment. if you can’t tell us anything, then don’t tell at all.

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Gene Expression

This blog is about evolution, genetics, genomics and their interstices. Please beware that comments are aggressively moderated. Uncivil or churlish comments will likely get you banned immediately, so make any contribution count!

About Razib Khan

I have degrees in biology and biochemistry, a passion for genetics, history, and philosophy, and shrimp is my favorite food. In relation to nationality I'm a American Northwesterner, in politics I'm a reactionary, and as for religion I have none (I'm an atheist). If you want to know more, see the links at http://www.razib.com

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