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	<title>Comments on: A golden age of sibling comparisons</title>
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	<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/</link>
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		<title>By: Razib Khan</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47980</link>
		<dc:creator>Razib Khan</dc:creator>
		<pubDate>Tue, 30 Oct 2012 06:09:24 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47980</guid>
		<description>dude, maybe. but you should stop talking like you are a behavior geneticist. at least to me ;-)</description>
		<content:encoded><![CDATA[<p>dude, maybe. but you should stop talking like you are a behavior geneticist. at least to me <img src='http://blogs.discovermagazine.com/gnxp/wp-includes/images/smilies/icon_wink.gif' alt=';-)' class='wp-smiley' /> </p>
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		<title>By: ohwilleke</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47979</link>
		<dc:creator>ohwilleke</dc:creator>
		<pubDate>Mon, 29 Oct 2012 19:02:28 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47979</guid>
		<description>&quot;if the environment is relatively uniform in a negative fashion that may be informative of the nature of response in variation across individuals of different genetic backgrounds.&quot;

Alas, Anna Karenina is on point here.  While posititive environments may all be similar to each other, negative environments can be negative in a multitude of individual ways.  There are probably a dozen common reasons that children are removed from their homes and the environmental effects associated with each one vary.  Unless you can sort based on reason for termination of parental rights (which is often legally suppressed by juvenile justice system rules), there are potentially signficant and hard to discern environmental exposure biases present.</description>
		<content:encoded><![CDATA[<p>&#8220;if the environment is relatively uniform in a negative fashion that may be informative of the nature of response in variation across individuals of different genetic backgrounds.&#8221;</p>
<p>Alas, Anna Karenina is on point here.  While posititive environments may all be similar to each other, negative environments can be negative in a multitude of individual ways.  There are probably a dozen common reasons that children are removed from their homes and the environmental effects associated with each one vary.  Unless you can sort based on reason for termination of parental rights (which is often legally suppressed by juvenile justice system rules), there are potentially signficant and hard to discern environmental exposure biases present.</p>
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		<title>By: Razib Khan</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47978</link>
		<dc:creator>Razib Khan</dc:creator>
		<pubDate>Mon, 29 Oct 2012 18:52:23 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47978</guid>
		<description>&lt;i&gt;since almost all foster parenting situations involve a fairly extended and almost always acutely negative period of environmental exposure at a developmentally critical time period in a genetic parent family before the foster parenting period begins. &lt;/i&gt;

as unpleasant as it is to consider, if the environment is relatively uniform in a &lt;i&gt;negative&lt;/i&gt; fashion that may be informative of the nature of response in variation across individuals of different genetic backgrounds.</description>
		<content:encoded><![CDATA[<p><i>since almost all foster parenting situations involve a fairly extended and almost always acutely negative period of environmental exposure at a developmentally critical time period in a genetic parent family before the foster parenting period begins. </i></p>
<p>as unpleasant as it is to consider, if the environment is relatively uniform in a <i>negative</i> fashion that may be informative of the nature of response in variation across individuals of different genetic backgrounds.</p>
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		<title>By: ohwilleke</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47977</link>
		<dc:creator>ohwilleke</dc:creator>
		<pubDate>Mon, 29 Oct 2012 18:45:51 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47977</guid>
		<description>&quot;Siblings share the same home environment.&quot;

In case of many traits, from personality to sexual orientation, birth order is a non-shared component of the otherwise shared environnment of siblings that may have material effects.

Of course, these issues are not present in the same way for fraternal twins.

Half-siblings pose much more useful natural experiements than foster parenting situations, since almost all foster parenting situations involve a fairly extended and almost always acutely negative period of environmental exposure at a developmentally critical time period in a genetic parent family before the foster parenting period begins.  This is not true to nearly the same extent in half-sibling situations. 

Within the universe of half siblings, cases in which war widows remarry and have new children might be particularly instructive as there is no selection bias in the sample for people who had poor marriages to start with that could have been a negative environmental impact on the older sibling.</description>
		<content:encoded><![CDATA[<p>&#8220;Siblings share the same home environment.&#8221;</p>
<p>In case of many traits, from personality to sexual orientation, birth order is a non-shared component of the otherwise shared environnment of siblings that may have material effects.</p>
<p>Of course, these issues are not present in the same way for fraternal twins.</p>
<p>Half-siblings pose much more useful natural experiements than foster parenting situations, since almost all foster parenting situations involve a fairly extended and almost always acutely negative period of environmental exposure at a developmentally critical time period in a genetic parent family before the foster parenting period begins.  This is not true to nearly the same extent in half-sibling situations. </p>
<p>Within the universe of half siblings, cases in which war widows remarry and have new children might be particularly instructive as there is no selection bias in the sample for people who had poor marriages to start with that could have been a negative environmental impact on the older sibling.</p>
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		<title>By: Razib Khan</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47976</link>
		<dc:creator>Razib Khan</dc:creator>
		<pubDate>Mon, 29 Oct 2012 16:05:37 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47976</guid>
		<description>#1, that&#039;s a hypothesis.  not been tested yet. though note that i&#039;m concerned more about average effects over many cohorts of siblings. don&#039;t expect much in 48 vs. 52 ibd.

#2, quantitative traits should reflect total genome content. i&#039;ve blogged this before at length; you&#039;re a long time reader, you should read me closer. there was a recent paper using genomic relatedness and IQ I believe. please google visscher, dreary, etc. not siblings though.

&lt;i&gt; And on a related note, is the maternal component going to be slightly larger in men since the X chromosome is bigger than the Y?&lt;/i&gt;

i think that&#039;s what&#039;s going on. there&#039;s not as much stuff on the Y. i don&#039;t even know if it&#039;s added into the computation? i just focus on the autosomes for that reason.</description>
		<content:encoded><![CDATA[<p>#1, that&#8217;s a hypothesis.  not been tested yet. though note that i&#8217;m concerned more about average effects over many cohorts of siblings. don&#8217;t expect much in 48 vs. 52 ibd.</p>
<p>#2, quantitative traits should reflect total genome content. i&#8217;ve blogged this before at length; you&#8217;re a long time reader, you should read me closer. there was a recent paper using genomic relatedness and IQ I believe. please google visscher, dreary, etc. not siblings though.</p>
<p><i> And on a related note, is the maternal component going to be slightly larger in men since the X chromosome is bigger than the Y?</i></p>
<p>i think that&#8217;s what&#8217;s going on. there&#8217;s not as much stuff on the Y. i don&#8217;t even know if it&#8217;s added into the computation? i just focus on the autosomes for that reason.</p>
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		<title>By: Superfast Jellyfish</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47975</link>
		<dc:creator>Superfast Jellyfish</dc:creator>
		<pubDate>Mon, 29 Oct 2012 14:46:06 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47975</guid>
		<description>#5--Right, but shouldn&#039;t the maternal sharing and paternal sharing add up to be about 100% instead of 97.2%? And on a related note, is the maternal component going to be slightly larger in men since the X chromosome is bigger than the Y?</description>
		<content:encoded><![CDATA[<p>#5&#8211;Right, but shouldn&#8217;t the maternal sharing and paternal sharing add up to be about 100% instead of 97.2%? And on a related note, is the maternal component going to be slightly larger in men since the X chromosome is bigger than the Y?</p>
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		<title>By: Karl Zimmerman</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47974</link>
		<dc:creator>Karl Zimmerman</dc:creator>
		<pubDate>Mon, 29 Oct 2012 12:59:52 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47974</guid>
		<description>4 -

I&#039;d hazard a guess this is because you don&#039;t share an X chromosome with your father (presuming you&#039;re male) and you don&#039;t share a Y chromosome with your mother.</description>
		<content:encoded><![CDATA[<p>4 -</p>
<p>I&#8217;d hazard a guess this is because you don&#8217;t share an X chromosome with your father (presuming you&#8217;re male) and you don&#8217;t share a Y chromosome with your mother.</p>
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		<title>By: Superfast Jellyfish</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47973</link>
		<dc:creator>Superfast Jellyfish</dc:creator>
		<pubDate>Mon, 29 Oct 2012 11:51:31 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47973</guid>
		<description>According to 23andme I share 49.9% of my genes with my mother and 47.3% with my father. Is it possible to have numbers that fall a few percentage points short of 100%, or is this just random error?</description>
		<content:encoded><![CDATA[<p>According to 23andme I share 49.9% of my genes with my mother and 47.3% with my father. Is it possible to have numbers that fall a few percentage points short of 100%, or is this just random error?</p>
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		<title>By: JL</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47972</link>
		<dc:creator>JL</dc:creator>
		<pubDate>Mon, 29 Oct 2012 11:48:55 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47972</guid>
		<description>Miley, regarding height, read the paper Razib linked to at the start of his post. As to IQ, I don&#039;t think this research design has yet been applied to it.</description>
		<content:encoded><![CDATA[<p>Miley, regarding height, read the paper Razib linked to at the start of his post. As to IQ, I don&#8217;t think this research design has yet been applied to it.</p>
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		<title>By: Miley Cyrax</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47971</link>
		<dc:creator>Miley Cyrax</dc:creator>
		<pubDate>Mon, 29 Oct 2012 01:56:18 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47971</guid>
		<description>Is there a correlation between sibling genomic similarity and the closeness of their height? What about genomic similarity and closeness of their IQ?</description>
		<content:encoded><![CDATA[<p>Is there a correlation between sibling genomic similarity and the closeness of their height? What about genomic similarity and closeness of their IQ?</p>
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		<title>By: Luke Raines</title>
		<link>http://blogs.discovermagazine.com/gnxp/2012/10/a-golden-age-of-sibling-comparisons/#comment-47970</link>
		<dc:creator>Luke Raines</dc:creator>
		<pubDate>Mon, 29 Oct 2012 00:54:09 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/gnxp/?p=18890#comment-47970</guid>
		<description>Quote: &quot;I also know that my relatedness to my siblings is 0.52, 0.51, and 0.48.&quot;

Do these differences in relatedness reflect any differences in your relationships with your siblings? I know the differences are small but I wonder if people can instinctively tell which siblings they are most similar to genetically and whether this knowledge is reflected in their relationships with those siblings.</description>
		<content:encoded><![CDATA[<p>Quote: &#8220;I also know that my relatedness to my siblings is 0.52, 0.51, and 0.48.&#8221;</p>
<p>Do these differences in relatedness reflect any differences in your relationships with your siblings? I know the differences are small but I wonder if people can instinctively tell which siblings they are most similar to genetically and whether this knowledge is reflected in their relationships with those siblings.</p>
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