Search Results for 'slc24a5'

SLC24A5 – more than just skin color?

October 5, 2007 | By | 8 Comments

Over the past few weeks I’ve been looking closely at all the skin color related genes in humans which have been studied over the past few years. A little over two years ago the evolutionary biologist Armand Leroi wrote: We don’t know what the differences are between white skin and black skin, European skin versus […]

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Selection happens; but where, when, and why?

November 8, 2013 | By | 8 Comments

One of the secondary issues which cropped up with Nina Davuluri winning Miss America is that it seems implausible that someone with her complexion would be able to win any Indian beauty contest. A quick skim of Google images “Miss India” will make clear the reality that I’m alluding to. The Indian beauty ideal, especially […]

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The end of genomics, the beginning of analysis

September 11, 2013 | By | Add a Comment

Evolutionary processes which play out across the tree of life are subject to distinct dynamics which can shape and influence the structure and characteristics of individuals, populations, and whole ecosystems. For example, imagine the phylogeny and population genetic characteristics of organisms which are endemic to the islands of Hawaii. Because the Hawaiian islands are an […]

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Pigmentation, phylogeny, history, and adaptation

August 7, 2013 | By | 25 Comments

The above figure is from Norton et al.’s Genetic Evidence for the Convergent Evolution of Light Skin in Europeans and East Asians. It shows that rs16891982 on the SLC45A2 locus exhibits strong differentiation between Europe and the rest of the world. This is in contrast to SLC24A5, where the well known allele which differentiates Africans/East Asians […]

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Buddy, can you spare a genetic distance statistic?

July 20, 2013 | By | Add a Comment

You have probably heard or read that most genetic variation is within races, not between races. This assertion has led, in my opinion, to unwarranted inferences. Often bracketed under “Lewontin’s Fallacy”, the basic intuition is that if most variation is within races, then races as a taxonomic unit are without utility or substantive basis. This […]

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Pigmentation: the simplest of complex traits not so simple?

March 24, 2013 | By | 6 Comments

One of the pitfalls about talking about genetics, especially human genetics, is that the public wants a specific gene for a specific trait. Ergo, the “God gene” or the “language gene.” In some cases science has been able to pull a rabbit out of the hat, and offer up a gene for a trait. But […]

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Evidence that Afrikaners surely have non-European ancestry

March 23, 2013 | By | 7 Comments

I was reviewing some literature for a blog-post-to-come and I noticed a figure in a paper I’ve long been aware of which indicates to me that Afrikaners surely have a non-trivial proportion of non-European ancestry. The paper is Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2. It’s a forensics result. Basically […]

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Is Girls’ Generation the outcome of the Pleistocene mind?

February 19, 2013 | By | 30 Comments

There’s an excellent paper up at Cell right now, Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant. It synthesizes genomics, computational modeling, as well as the effective execution of mouse models to explore non-pathological phenotypic variation in humans. It was likely due the last element that this paper, which pushes […]

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Not all genes are created the same

August 28, 2012 | By | Add a Comment

The map to the right shows the frequencies of HGDP populations on SLC45A2, which is a locus that has been implicated in skin color variation in humans. It’s for the SNP rs16891982, and I yanked the figure from IrisPlex: A sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence […]

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Europeans got less shaded in stages

August 27, 2012 | By | 24 Comments

The Pith: the evolution of lighter skin is complex, and seems to have occurred in stages. The current European phenotype may date to the end of the last Ice Age. A new paper in Molecular Biology and Evolution, The timing of pigmentation lightening in Europeans, is rather interesting. It’s important because skin pigmentation has been […]

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The law of reversion to type as cultural illusion

August 9, 2012 | By | 26 Comments

A comment below: Does the higher genetic diversity in sub-Saharan Africans explain why mixed children of blacks + other couples usually look more black than anything? As in, the higher number of genetic characteristics overwhelms those of the other parent and allows them to be present in the child. But this makes you ask: is […]

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Ashkenazi Jews are not inbred – 2

July 21, 2012 | By | 7 Comments

I know I excoriate readers of this weblog for being stupid, ignorant, or lazy. But this constant badgering does result in genuinely insightful and important comments precisely and carefully stated on occasion. I put up my previous post in haste, and when I published it I wasn’t totally happy with the evidence from which the […]

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Not out of Sheba

June 22, 2012 | By | 9 Comments

Liya Kebede, Credit There is a new paper, Ethiopian Genetic Diversity Reveals Linguistic Stratification and Complex Influences on the Ethiopian Gene Pool, which is being sensationalized in the media. For example, the BBC headline: ‘DNA clues to Queen of Sheba tale’. I assumed that this was just the media, but to my surprise the authors […]

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The evolution of the human face

March 26, 2012 | By | 31 Comments

The face is an important aspect of our phenotype. So important that facial recognition is one of many innate reflexive cognitive competencies. By this, I mean that you can recognize a face in a gestalt manner, just like you can recognize a set of three marbles. You don’t have to think about it in a […]

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Neanderthals came in all colors

March 19, 2012 | By | 13 Comments

There’s a report in Science about a new short paper about Neandertal pigmentation genetics. The context is this. First, in 2007 an ingenuous paper was published which inferred that it may be that Neandertals had red hair, at least based on an N = 2 from two divergent locations. The new study looks at three […]

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Natural selection and dopamine receptor genes

March 9, 2012 | By | 3 Comments

Long time readers will be familiar with the large literature in behavior genetics/genomics and dopamine receptor genes. So with that, I point you to a paper exploring the patterns of variation and their relationship to possible natural selection, No Evidence for Strong Recent Positive Selection Favoring the 7 Repeat Allele of VNTR in the DRD4 […]

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The social and biological construction of race

February 12, 2012 | By | 36 Comments

Many of our categories are human constructions which map upon patterns in nature which we perceive rather darkly. The joints about which nature turns are as they are, our own names and representations are a different thing altogether. This does not mean that our categories have no utility, but we should be careful of confusing […]

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Mendelism is not magic

January 16, 2012 | By | 16 Comments

Michelle points me to this article in The Lost Angeles Times, The Colors of the Family: I was holding my 1-year-old, ambling about downtown with some friends. White friends. She must have thought my boy belonged to one of them. There’s a simple explanation: I’m black but my son, Ashe, is white. At least he […]

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Peeling the population genetic Indian onion

December 8, 2011 | By | 12 Comments

There’s a new paper in The American Journal of Human Genetics, Shared and Unique Components of Human Population Structure and Genome-Wide Signals of Positive Selection in South Asia. It’s free, so go read it. I don’t have time to comment in detail, but I did read the paper, and I want to mention a few […]

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But it still adapts!

December 4, 2011 | By | 6 Comments

Dienekes and Maju recently pointed to a paper, Contrasting signals of positive selection in genes involved in human skin color variation from tests based on SNP scans and resequencing, in Investigative Genetics. Skin color is an interesting trait because it’s one of the big “wins” in human genomics over the past 10 years. To a great […]

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