Search Results for 'slc24a5'

Dominance, the social construct that confuses

July 25, 2011 | By | Add a Comment

A story in The Los Angeles Times seems to point medical implications of being a sickle cell carrier, Sickle cell trait: The silent killer: At least 17 high school and college athletes’ deaths have been tied to sickle cell trait during the past 11 years. The group includes Olivier Louis, a player at Wekiva High […]

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Southeast Asian migrations, Indians and Tai

July 23, 2011 | By | Add a Comment

If you have not read my post “To the antipode of Asia”, this might be a good time to do so if you are unfamiliar with the history, prehistory, and ethnography of mainland Southeast Asia. In this post I will focus on mainland Southeast Asia, and how it relates implicitly to India and China genetically, […]

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The rise of genetic architecture

January 19, 2011 | By | Add a Comment

In science, like most things, one prefers simple over complex whenever possible. You keep adding variables until the explanatory juice starts hitting diminishing marginal returns. So cystic fibrosis is due to a mutation at one gene, and the disease expresses recessively at that locus. The reality is that one mutation accounts for ~65-70% of cystic […]

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Of association & evolution

January 9, 2011 | By | Add a Comment

Two of the main avenues of research which I track rather closely in this space are genome-wide association studies (GWAS), which attempt to establish a connection between a trait/disease and particular genetic markers, and inquiries into the evolutionary parameters which shape the structure of variation within the human genome. Often with specific relation to a particular […]

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To classify humanity is not that hard

December 14, 2010 | By | Add a Comment

In my post below I quoted my interview L. L. Cavalli-Sforza because I think it gets to the heart of some confusions which have emerged since the finding that most variation on any given locus is found within populations, rather than between them. The standard figure is that 85% of genetic variance is within continental […]

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Every variant with an author!

September 29, 2010 | By | Add a Comment

I recall projections in the early 2000s that 25% of the American population would be employed as systems administrators circa 2020 if rates of employment growth at that time were extrapolated. Obviously the projections weren’t taken too seriously, and the pieces were generally making fun of the idea that IT would reduce labor inputs and […]

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Not all genes are equal in the eyes of man

September 13, 2010 | By | Add a Comment

A few days ago I was listening to an interview with a reporter who was kidnapped in the tribal areas of Pakistan (he eventually escaped). Because he was a Westerner he mentioned offhand that to “pass” as a native for his own safety he had his guides claim he was Nuristani when inquiries were made. […]

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Chosen genes of the Chosen People

August 27, 2010 | By | Add a Comment

Last spring two very thorough papers came out which surveyed the genetic landscape of the Jewish people (my posts, Genetics & the Jews it’s still complicated, Genetics & the Jews). The novelty of the results was due to the fact that the research groups actually looked across the very diverse populations of the Diaspora, from […]

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Desmond Tutu, Spaniards, and genetic distance

August 21, 2010 | By | Add a Comment

Since we’ve been talking about Fst a fair amount, I thought it might be nice to put it in some concrete graphical perspective. First, to review Fst in the genetic context measures the proportion of genetic variation which can be attributed to between population differences. To give a “toy” example if you randomly divided the […]

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PCA, Razib around the world (a little)

August 10, 2010 | By | Add a Comment

I have put up a few posts warning readers to be careful of confusing PCA plots with real genetic variation. PCA plots are just ways to capture variation in large data sets and extract out the independent dimensions. Its great at detecting population substructure because the largest components of variation often track between population differences, […]

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Better prediction through better measurement

May 11, 2010 | By | Add a Comment

One of the most successful achievements of the “post-genomic era” has been the elucidation of the genetic architecture which undergird the variation in human pigmentation. I like to point out that in 2005 the geneticist Armand Leroi observed in his book Mutants that we didn’t know the genetics of normal variation in relation to the […]

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Natural selection & recombination in the human genome

March 26, 2010 | By | Add a Comment

If you are like me, and if you are reading this weblog there is a significant probability you are like me, you read L. L. Cavalli-Sforza‘s History and Geography of Human Genes in the 1990s, and in the early aughts Spencer Wells’ A Journey of Man. Science has come very far in the last in […]

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OCA2 makes East Asians white and Europeans blue

March 5, 2010 | By | Add a Comment

Over the history of this weblog I have blogged about pigmentation a fair amount. The major reason is that that’s where the money is; unlike height, let alone intelligence, the genetic architecture and evolutionary history of pigmentation has been elucidated with relative clarity. That is, we know roughly the number and nature of the genes […]

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The parallel lives of threespine stickleback

March 1, 2010 | By | Add a Comment

A few days ago I pointed to a paper which suggests the possible utility of looking at selection on standing genetic variation on quantitative traits to get a sense of the role of adaptation in the human genome. We humans like to think we’re a complex species, so I see no a priori reason why […]

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The genetics of Scottish hair color variation

January 7, 2010 | By | Add a Comment

In the aughts the elucidation of human pigmentation genetics was of one the major successes of ‘omic’ techniques. The fact that humans exhibit some continuous variation in complexion was strongly suggestive that more than one gene was at work to generate the range of the phenotype. On the other hand pedigree based studies going back […]

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Obesity as part of normal human variation

August 20, 2009 | By | Add a Comment

Common body mass index-associated variants confer risk of extreme obesity: To investigate the genetic architecture of severe obesity, we performed a genome-wide association study of 775 cases and 3197 unascertained controls at 550 000 markers across the autosomal genome. We found convincing association to the previously described locus including the FTO gene. We also found […]

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93 ancestrally informative markers to categorize them all

July 30, 2009 | By | Add a Comment

An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels: Results In this study, genotypes from Human Genome Diversity Panel populations were used to further evaluate a 93 SNP AIM panel, a subset of the 128 AIMS set, for distinguishing continental origins. Using both model-based and relatively model-independent […]

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What makes the mice nice

June 9, 2009 | By | Add a Comment

Domestication has a long history. It predates the invention of writing by thousands of years. In the history of biology the study of domestication is closely connected to the emergence of experimental and theoretical biology out of the shadow of natural history. Chapter I of The Origin of Species is preoccupied with animal breeding. The […]

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Adaptation might not be a spherical cow

June 5, 2009 | By | Add a Comment

In Natural selection of a human gene: FUT2 I referred to a paper, Signals of recent positive selection in a worldwide sample of human populations (see my earlier review). Now the same group has a follow up paper which takes a slightly different tack, The Role of Geography in Human Adaptation: Since the beginning of […]

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Skin color is not race

May 14, 2009 | By | Add a Comment

One of the peculiarities of American discussion about race is that skin color is assumed to be synonymous with racial distinctions. That is, skin color is not just a trait, but it is the trait which defines between population differences. There’s a reason for this, the skin is the largest organ and it is very […]

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