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	<title>Comments on: Malaria For Brains</title>
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	<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/</link>
	<description>A blog about life, past and future. Written by DISCOVER contributing editor and columnist Carl Zimmer.</description>
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		<title>By: Homer</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7695</link>
		<dc:creator>Homer</dc:creator>
		<pubDate>Mon, 29 Aug 2005 17:20:35 +0000</pubDate>
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		<description>It would be interesting to see if there were any connection between this shift of sugar hooks and autism, which might be a mutation of human brain development processes.  Might chimpanzee malaria be able to attach to the blood of autistic individuals?</description>
		<content:encoded><![CDATA[<p>It would be interesting to see if there were any connection between this shift of sugar hooks and autism, which might be a mutation of human brain development processes.  Might chimpanzee malaria be able to attach to the blood of autistic individuals?</p>
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		<title>By: John S Bolton</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7694</link>
		<dc:creator>John S Bolton</dc:creator>
		<pubDate>Thu, 25 Aug 2005 23:49:59 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7694</guid>
		<description>There is a huge disproportion between the chances for a good versus a bad mutation. If this is not so, why are we wasting so much time and money on protecting people from mutagenic radiation? Why aren&#039;t the bold seekers of new possibilities exposing their germline cells to radiation, if  the chances for a good mutation are within range of what some might try? A deletion mutant which disbles part of the deliberate design, so to speak, only to frustrate a parasite, looks like natural selection, not like the intelligent way to make man.</description>
		<content:encoded><![CDATA[<p>There is a huge disproportion between the chances for a good versus a bad mutation. If this is not so, why are we wasting so much time and money on protecting people from mutagenic radiation? Why aren&#8217;t the bold seekers of new possibilities exposing their germline cells to radiation, if  the chances for a good mutation are within range of what some might try? A deletion mutant which disbles part of the deliberate design, so to speak, only to frustrate a parasite, looks like natural selection, not like the intelligent way to make man.</p>
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		<title>By: Dan S.</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7693</link>
		<dc:creator>Dan S.</dc:creator>
		<pubDate>Thu, 25 Aug 2005 19:35:52 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7693</guid>
		<description>&quot;Deletion mutants decrease information content. Mutations are randomization and thus destruction of genetic information&quot;

I&#039;m not a scientist, and don&#039;t even have much informal education about this, besides some pop science stuff.  But as far as I can understand, this is missing the point that DNA isn&#039;t a &lt;i&gt;book&lt;/i&gt; (although spoken and written language is so redundant that up to a a point even extensive garbage, duplications, etc, won&#039;t effect the the abilty to ndrstnd wht s bng sd dnt you gurble agree?).  It&#039;s sort of a like a house blueprint that actually makes a house.  If some of the details get changed, there might be a big problem - uh oh, no outside door!  toliet draining into bedroom! loss of structural support!- it might not make a  difference (unseen supporting beams are a different color), it might be an improvement - hey, a window there? I like that!  There might be minute changes in insulation thickness, pipe material, wiring that might be improvements, problems, etc., depending on living conditions (thicker insulation in Alaska? Good.  In Brazil?  Maybe not?)  But a lot more complex.

I don&#039;t get ID creationism.  It insists that things are very complex, yet very simple.  Doesn&#039;t seem interested in actually appreciating how cool thing are.</description>
		<content:encoded><![CDATA[<p>&#8220;Deletion mutants decrease information content. Mutations are randomization and thus destruction of genetic information&#8221;</p>
<p>I&#8217;m not a scientist, and don&#8217;t even have much informal education about this, besides some pop science stuff.  But as far as I can understand, this is missing the point that DNA isn&#8217;t a <i>book</i> (although spoken and written language is so redundant that up to a a point even extensive garbage, duplications, etc, won&#8217;t effect the the abilty to ndrstnd wht s bng sd dnt you gurble agree?).  It&#8217;s sort of a like a house blueprint that actually makes a house.  If some of the details get changed, there might be a big problem &#8211; uh oh, no outside door!  toliet draining into bedroom! loss of structural support!- it might not make a  difference (unseen supporting beams are a different color), it might be an improvement &#8211; hey, a window there? I like that!  There might be minute changes in insulation thickness, pipe material, wiring that might be improvements, problems, etc., depending on living conditions (thicker insulation in Alaska? Good.  In Brazil?  Maybe not?)  But a lot more complex.</p>
<p>I don&#8217;t get ID creationism.  It insists that things are very complex, yet very simple.  Doesn&#8217;t seem interested in actually appreciating how cool thing are.</p>
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		<title>By: John S Bolton</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7692</link>
		<dc:creator>John S Bolton</dc:creator>
		<pubDate>Thu, 25 Aug 2005 02:24:14 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7692</guid>
		<description>Deletion mutants decrease information content. Mutations are randomization and thus destruction of genetic information, except for the very rare ones which actually improve the informational content functionally. If not so, then why would lethal mutagenesis be lethal, rather than an enrichment of genetic informational diversity?</description>
		<content:encoded><![CDATA[<p>Deletion mutants decrease information content. Mutations are randomization and thus destruction of genetic information, except for the very rare ones which actually improve the informational content functionally. If not so, then why would lethal mutagenesis be lethal, rather than an enrichment of genetic informational diversity?</p>
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		<title>By: ruidh</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7691</link>
		<dc:creator>ruidh</dc:creator>
		<pubDate>Wed, 24 Aug 2005 17:12:16 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7691</guid>
		<description>Doug,

Any mutation *increases* the information content of the species genome. The assertion that the mutution reduces information content of the genome is contrafactual.

Natural selection then operates to reduce that information content over long periods of time by selecting for strongly advantageous mutations and selecting against strongly disadvantageous mutations.

This ebb and flow of information over time is how evolution works. The net result is a tendancy to increase the information content of all genomes summed across all species corresponding to biological diversity.</description>
		<content:encoded><![CDATA[<p>Doug,</p>
<p>Any mutation *increases* the information content of the species genome. The assertion that the mutution reduces information content of the genome is contrafactual.</p>
<p>Natural selection then operates to reduce that information content over long periods of time by selecting for strongly advantageous mutations and selecting against strongly disadvantageous mutations.</p>
<p>This ebb and flow of information over time is how evolution works. The net result is a tendancy to increase the information content of all genomes summed across all species corresponding to biological diversity.</p>
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		<title>By: Juan</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7690</link>
		<dc:creator>Juan</dc:creator>
		<pubDate>Wed, 24 Aug 2005 15:31:09 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7690</guid>
		<description>Just curious:
Doug wrote:&quot;If the research were conducted under a creationist methodology the result would be the same.&quot; Isn&#039;t this a self contradictory sentence or oxymoron.
I always thought that creationism is faith based: you belief in it or not. Period. Ergo, there can not be any methodology or research in creationism as they are mutually exclusive.</description>
		<content:encoded><![CDATA[<p>Just curious:<br />
Doug wrote:&#8221;If the research were conducted under a creationist methodology the result would be the same.&#8221; Isn&#8217;t this a self contradictory sentence or oxymoron.<br />
I always thought that creationism is faith based: you belief in it or not. Period. Ergo, there can not be any methodology or research in creationism as they are mutually exclusive.</p>
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		<title>By: Jo&#227;o Carlos</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7689</link>
		<dc:creator>Jo&#227;o Carlos</dc:creator>
		<pubDate>Wed, 24 Aug 2005 14:52:26 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7689</guid>
		<description>An interesting issue here is that is possible say that Plasmodium falciparum speciated 3 million years ago. When Plasmodium falciparum get stuck inside hominid red blobs it lost the hability to infect other primates red blobs. A reprodutive barrier was formed when that happened.

So, the data give us information about a speciation event. But creationists will lie and say that there is no proof that evolution will give speciation.

Creationists are liars, they forget that there is a Commandement to not lie inside the Bible. They will go to Hell. :p

Jo&#227;o Carlos

Sorry the bad english, my native language is portuguese.</description>
		<content:encoded><![CDATA[<p>An interesting issue here is that is possible say that Plasmodium falciparum speciated 3 million years ago. When Plasmodium falciparum get stuck inside hominid red blobs it lost the hability to infect other primates red blobs. A reprodutive barrier was formed when that happened.</p>
<p>So, the data give us information about a speciation event. But creationists will lie and say that there is no proof that evolution will give speciation.</p>
<p>Creationists are liars, they forget that there is a Commandement to not lie inside the Bible. They will go to Hell. :p</p>
<p>Jo&atilde;o Carlos</p>
<p>Sorry the bad english, my native language is portuguese.</p>
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		<title>By: Dan S.</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7688</link>
		<dc:creator>Dan S.</dc:creator>
		<pubDate>Wed, 24 Aug 2005 03:19:11 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7688</guid>
		<description>To be fair, the moral and ethical values content of evolutionary theory is likewise basically nonexistant.*  Of course, nobody expects science to provide such things (unless they&#039;re very, very, very silly people . . .

* Of course, other (mainstream) religious interpretations and traditions, as well as many non-religious systems, offer these values, often without pretending to be science out of some strange sense of aggrieved inferiority.

Now back to the science . . .</description>
		<content:encoded><![CDATA[<p>To be fair, the moral and ethical values content of evolutionary theory is likewise basically nonexistant.*  Of course, nobody expects science to provide such things (unless they&#8217;re very, very, very silly people . . .</p>
<p>* Of course, other (mainstream) religious interpretations and traditions, as well as many non-religious systems, offer these values, often without pretending to be science out of some strange sense of aggrieved inferiority.</p>
<p>Now back to the science . . .</p>
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		<title>By: Dan S.</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7687</link>
		<dc:creator>Dan S.</dc:creator>
		<pubDate>Wed, 24 Aug 2005 03:14:57 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7687</guid>
		<description>Doug, you&#039;re missing the point again, I think.  The entire scenario is based on chimps and humans evolving from a common ancestor; likewise with  &lt;i&gt;P. rechnowi&lt;/i&gt; and &lt;i&gt;P. falciparum&lt;/i&gt;.

Frankly, I can&#039;t understand what you&#039;re saying.  People have used genetics to study the relationship between different varieties and species of brassicas (although it gets a little hinky what with hybridization and weird plant stuff).  They&#039;re descended from a common ancestor, although in this case many of the changes result from artificial selection.  Sugar and table beets are related to swiss chard, they&#039;re related to spinach, and they&#039;re related to lambquarters (Chenopodium spp.)  (I may be garbling the details here, but this is the general idea).  Common descent.  What&#039;s the problem?

In regard to the use of the word &quot;evolution,&quot; remember that for science, beet to sugar beet and goo* to you (I do love that phrase, although adding in &#039;zoo&#039; makes it too unwieldy, methinks) is essentially the same thing.

* living goo, though.  Evolution doesn&#039;t deal with how life started, just what it did once it showed up.
___________

Something Carl is very good at is conveying the excitement - both of pure discovery and practical knowledge - of such research.  Creationism, for its adherents, surely offers a kind of satisfaction, but it is of a very different nature.  The scientific-wonder-and-productive-usefulness content of creationism seems to me to be essentially nil.

&quot;So if we engineered Neu5Gc out of Chimps they might develop bigger brains? Cool.&quot;
Great, just what we need, intelligent poop-flingers . . .

. . . wait.  Don&#039;t we have those already . . .?

Carl, any chance you&#039;d toss something off here about recent work using genetic material extracted from ancient bones to work out evolutionary relationships, etc?   Besides the thing with the &lt;a href=&quot;http://biology.plosjournals.org/perlserv/?request=get-document&amp;doi=10.1371/journal.pbio.0030241&quot; rel=&quot;nofollow&quot;&gt;horses&lt;/a&gt;, there was something cool released earlier this month &lt;a href=&quot;http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6VRT-4GTVWB4-B&amp;_coverDate=08%2F09%2F2005&amp;_alid=306310628&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_qd=1&amp;_cdi=6243&amp;_sort=d&amp;view=c&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=b58bc9b913c2957d0751731bcccd5498&quot; rel=&quot;nofollow&quot;&gt;about&lt;/a&gt;  cougars, cheetahs, Miracinonyx and sabretooths . . .   (oh my!)</description>
		<content:encoded><![CDATA[<p>Doug, you&#8217;re missing the point again, I think.  The entire scenario is based on chimps and humans evolving from a common ancestor; likewise with  <i>P. rechnowi</i> and <i>P. falciparum</i>.</p>
<p>Frankly, I can&#8217;t understand what you&#8217;re saying.  People have used genetics to study the relationship between different varieties and species of brassicas (although it gets a little hinky what with hybridization and weird plant stuff).  They&#8217;re descended from a common ancestor, although in this case many of the changes result from artificial selection.  Sugar and table beets are related to swiss chard, they&#8217;re related to spinach, and they&#8217;re related to lambquarters (Chenopodium spp.)  (I may be garbling the details here, but this is the general idea).  Common descent.  What&#8217;s the problem?</p>
<p>In regard to the use of the word &#8220;evolution,&#8221; remember that for science, beet to sugar beet and goo* to you (I do love that phrase, although adding in &#8216;zoo&#8217; makes it too unwieldy, methinks) is essentially the same thing.</p>
<p>* living goo, though.  Evolution doesn&#8217;t deal with how life started, just what it did once it showed up.<br />
___________</p>
<p>Something Carl is very good at is conveying the excitement &#8211; both of pure discovery and practical knowledge &#8211; of such research.  Creationism, for its adherents, surely offers a kind of satisfaction, but it is of a very different nature.  The scientific-wonder-and-productive-usefulness content of creationism seems to me to be essentially nil.</p>
<p>&#8220;So if we engineered Neu5Gc out of Chimps they might develop bigger brains? Cool.&#8221;<br />
Great, just what we need, intelligent poop-flingers . . .</p>
<p>. . . wait.  Don&#8217;t we have those already . . .?</p>
<p>Carl, any chance you&#8217;d toss something off here about recent work using genetic material extracted from ancient bones to work out evolutionary relationships, etc?   Besides the thing with the <a href="http://biology.plosjournals.org/perlserv/?request=get-document&amp;doi=10.1371/journal.pbio.0030241" rel="nofollow">horses</a>, there was something cool released earlier this month <a href="http://www.sciencedirect.com/science?_ob=ArticleURL&amp;_udi=B6VRT-4GTVWB4-B&amp;_coverDate=08%2F09%2F2005&amp;_alid=306310628&amp;_rdoc=1&amp;_fmt=&amp;_orig=search&amp;_qd=1&amp;_cdi=6243&amp;_sort=d&amp;view=c&amp;_acct=C000050221&amp;_version=1&amp;_urlVersion=0&amp;_userid=10&amp;md5=b58bc9b913c2957d0751731bcccd5498" rel="nofollow">about</a>  cougars, cheetahs, Miracinonyx and sabretooths . . .   (oh my!)</p>
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		<title>By: Nick (Matzke)</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7686</link>
		<dc:creator>Nick (Matzke)</dc:creator>
		<pubDate>Tue, 23 Aug 2005 23:51:15 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7686</guid>
		<description>Creationists/IDers couldn&#039;t come up with a rigorous definition of &quot;information increase&quot; vs. &quot;information decrease&quot; if their life depended on it.  They employ these terms in contradictory, arbitrary ways to discount any proposed example, and their arguments rely on a vague colloquial definition of &quot;information&quot; rather than anything resembling real information theory, which is entirely about the transmission and storing of messages, and not at all about &quot;meaning&quot;.  See:

Information Theory and Creationism
&lt;a href=&quot;http://www.talkorigins.org/faqs/information/infotheory.html&quot; rel=&quot;nofollow&quot;&gt;&lt;a href=&quot;http://www.talkorigins.org/faqs/information/infotheory.html&quot; rel=&quot;nofollow&quot;&gt;http://www.talkorigins.org/faqs/information/infotheory.html&lt;/a&gt;&lt;/a&gt;

For examples of the evolution of new genes with new functions, which should count as &quot;new genetic information&quot; in anybody&#039;s book, see:

Evolution of new information
&lt;a href=&quot;http://www.evowiki.org/index.php/Evolution_of_new_information&quot; rel=&quot;nofollow&quot;&gt;&lt;a href=&quot;http://www.evowiki.org/index.php/Evolution_of_new_information&quot; rel=&quot;nofollow&quot;&gt;http://www.evowiki.org/index.php/Evolution_of_new_information&lt;/a&gt;&lt;/a&gt;

And don&#039;t give us any rubbish about these just being examples of mere &quot;reshuffling&quot;.  If you end up with two different genes with different functions, where you originally had one, you&#039;ve got more &quot;information&quot;, using any reasonable definition.

Note to creationists: Not every writing on evolution is an attempt to your peculiar half-baked argument and quarter-baked definitions.  In this post, was Zimmer trying to show how &quot;new information&quot;, whatever the creationists mean by that slogan, arises?  Clearly not.

PS: On a completely different topic: The loss of Neu5Gc in the brains of hominids could simply be another step in malaria avoidance.  Malaria gets particularly deadly when it gets into the brain.</description>
		<content:encoded><![CDATA[<p>Creationists/IDers couldn&#8217;t come up with a rigorous definition of &#8220;information increase&#8221; vs. &#8220;information decrease&#8221; if their life depended on it.  They employ these terms in contradictory, arbitrary ways to discount any proposed example, and their arguments rely on a vague colloquial definition of &#8220;information&#8221; rather than anything resembling real information theory, which is entirely about the transmission and storing of messages, and not at all about &#8220;meaning&#8221;.  See:</p>
<p>Information Theory and Creationism<br />
<a href="http://www.talkorigins.org/faqs/information/infotheory.html" rel="nofollow"></a><a href="http://www.talkorigins.org/faqs/information/infotheory.html" rel="nofollow">http://www.talkorigins.org/faqs/information/infotheory.html</a></p>
<p>For examples of the evolution of new genes with new functions, which should count as &#8220;new genetic information&#8221; in anybody&#8217;s book, see:</p>
<p>Evolution of new information<br />
<a href="http://www.evowiki.org/index.php/Evolution_of_new_information" rel="nofollow"></a><a href="http://www.evowiki.org/index.php/Evolution_of_new_information" rel="nofollow">http://www.evowiki.org/index.php/Evolution_of_new_information</a></p>
<p>And don&#8217;t give us any rubbish about these just being examples of mere &#8220;reshuffling&#8221;.  If you end up with two different genes with different functions, where you originally had one, you&#8217;ve got more &#8220;information&#8221;, using any reasonable definition.</p>
<p>Note to creationists: Not every writing on evolution is an attempt to your peculiar half-baked argument and quarter-baked definitions.  In this post, was Zimmer trying to show how &#8220;new information&#8221;, whatever the creationists mean by that slogan, arises?  Clearly not.</p>
<p>PS: On a completely different topic: The loss of Neu5Gc in the brains of hominids could simply be another step in malaria avoidance.  Malaria gets particularly deadly when it gets into the brain.</p>
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		<title>By: Richard Dietzel</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7685</link>
		<dc:creator>Richard Dietzel</dc:creator>
		<pubDate>Tue, 23 Aug 2005 23:05:00 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7685</guid>
		<description>So if we engineered Neu5Gc out of Chimps they might develop bigger brains?  Cool.</description>
		<content:encoded><![CDATA[<p>So if we engineered Neu5Gc out of Chimps they might develop bigger brains?  Cool.</p>
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		<title>By: John S Bolton</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7684</link>
		<dc:creator>John S Bolton</dc:creator>
		<pubDate>Tue, 23 Aug 2005 22:39:32 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7684</guid>
		<description>This information fits with the idea that escape from malaria correlates positively with evolution of greater brain capacities. The spread of falciparum malaria, in its more modern and virulent form, into subtropical regions in classical antiquity, is associated with cultural and even population decline. Sallares and Coluzzi say that Rome suffered irreparably from this. Perhaps the intelligent design believers will explain that this was a delayed punishment of the ancients for their impiety.</description>
		<content:encoded><![CDATA[<p>This information fits with the idea that escape from malaria correlates positively with evolution of greater brain capacities. The spread of falciparum malaria, in its more modern and virulent form, into subtropical regions in classical antiquity, is associated with cultural and even population decline. Sallares and Coluzzi say that Rome suffered irreparably from this. Perhaps the intelligent design believers will explain that this was a delayed punishment of the ancients for their impiety.</p>
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		<title>By: Doug</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7683</link>
		<dc:creator>Doug</dc:creator>
		<pubDate>Tue, 23 Aug 2005 21:48:34 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7683</guid>
		<description>In this scenario, Carl has pointed out the following two genetic changes as the cause of Malaria&#039;s success against humans. First human ancestors lose the Neu5Gc sugar.

&lt;blockquote&gt;...because the enzyme that converts the precursor Neu5Ac into Neu5Gc doesn&#039;t work. We still carry the gene for the enzyme, but it became mutated...&lt;/blockquote&gt;

This change is a result of a loss of function. This is an example of a mutation that provides a benefit, at least initially, but does nothing to suggest that new function is evolving, only &quot;disolving&quot;.

Carl goes on to say:
&lt;blockquote&gt;But this relief did not last, the scientists argue. Sometimes mutant parasites emerged that did a better job of latching onto the one sugar hominids still made, Neu5Ac...But at the same time, they surrendered the ability to infect other apes, such as chimpanzees. &lt;/blockquote&gt;

This event is not quite as specific as the previous one but it may share a similar problem. The change resulted in some of the parasites having a greater affinity for the Neu5Ac sugar but it came at a cost. The net result is that it is better at doing something that it already did which doesn&#039;t suggest the emergence of a new ability only the honing of a skill which came at the cost of losing function.

Carl writes, &quot;This new research is yet another example of how studying evolution yields new insights into medicine.&quot;

This is an excellent example of the vague use of the term evolution. In saying &quot;evolution&quot; the audience generaly assumes a  molecules-to-man or common descent definition. The truth is, in the first event, this is merely an instance of a loss of genetic information through mutation. While less is described about the second event it appears to be the result of natural selection selecting genes with greater affinity for Neu5Ac. Similar to the &quot;unnatural&quot; selection of farmers when attempting to increase the sugar content of the sugar beet. The genetic information already existed. It is therefore not evidence for common descent. If the research were conducted under a creationist methodology the result would be the same.

For a short article summarizing the creationist view on genetics I encourage you to read this article by  Dr Lane P. Lester. He is a graduate of the University of Florida and holds a Ph.D. in genetics from Purdue University, and M.S. in ecology.

&lt;a href=&quot;http://www.answersingenesis.org/docs/1356.asp&quot; rel=&quot;nofollow&quot;&gt;Genetics: No Friend of Evolution&lt;/a&gt;


Incidently, I hope you don&#039;t mind me referring to you as Carl instead of the more formal Mr Zimmer.  It should not be regarded as a lack of respect. Your style strikes me as someone laid back enough not to care. There certainly are those that would take it as being condescending in nature. They would be wrong, but I&#039;m happy to address you however you prefer.</description>
		<content:encoded><![CDATA[<p>In this scenario, Carl has pointed out the following two genetic changes as the cause of Malaria&#8217;s success against humans. First human ancestors lose the Neu5Gc sugar.</p>
<blockquote><p>&#8230;because the enzyme that converts the precursor Neu5Ac into Neu5Gc doesn&#8217;t work. We still carry the gene for the enzyme, but it became mutated&#8230;</p></blockquote>
<p>This change is a result of a loss of function. This is an example of a mutation that provides a benefit, at least initially, but does nothing to suggest that new function is evolving, only &#8220;disolving&#8221;.</p>
<p>Carl goes on to say:</p>
<blockquote><p>But this relief did not last, the scientists argue. Sometimes mutant parasites emerged that did a better job of latching onto the one sugar hominids still made, Neu5Ac&#8230;But at the same time, they surrendered the ability to infect other apes, such as chimpanzees. </p></blockquote>
<p>This event is not quite as specific as the previous one but it may share a similar problem. The change resulted in some of the parasites having a greater affinity for the Neu5Ac sugar but it came at a cost. The net result is that it is better at doing something that it already did which doesn&#8217;t suggest the emergence of a new ability only the honing of a skill which came at the cost of losing function.</p>
<p>Carl writes, &#8220;This new research is yet another example of how studying evolution yields new insights into medicine.&#8221;</p>
<p>This is an excellent example of the vague use of the term evolution. In saying &#8220;evolution&#8221; the audience generaly assumes a  molecules-to-man or common descent definition. The truth is, in the first event, this is merely an instance of a loss of genetic information through mutation. While less is described about the second event it appears to be the result of natural selection selecting genes with greater affinity for Neu5Ac. Similar to the &#8220;unnatural&#8221; selection of farmers when attempting to increase the sugar content of the sugar beet. The genetic information already existed. It is therefore not evidence for common descent. If the research were conducted under a creationist methodology the result would be the same.</p>
<p>For a short article summarizing the creationist view on genetics I encourage you to read this article by  Dr Lane P. Lester. He is a graduate of the University of Florida and holds a Ph.D. in genetics from Purdue University, and M.S. in ecology.</p>
<p><a href="http://www.answersingenesis.org/docs/1356.asp" rel="nofollow">Genetics: No Friend of Evolution</a></p>
<p>Incidently, I hope you don&#8217;t mind me referring to you as Carl instead of the more formal Mr Zimmer.  It should not be regarded as a lack of respect. Your style strikes me as someone laid back enough not to care. There certainly are those that would take it as being condescending in nature. They would be wrong, but I&#8217;m happy to address you however you prefer.</p>
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		<title>By: Dave</title>
		<link>http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/comment-page-1/#comment-7682</link>
		<dc:creator>Dave</dc:creator>
		<pubDate>Tue, 23 Aug 2005 21:39:52 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2005/08/23/malaria-for-brains/#comment-7682</guid>
		<description>Dolphins have relatively large brains in comparison to body mass.  Is it known if their cells express as much Neu5Gc as other mammals?</description>
		<content:encoded><![CDATA[<p>Dolphins have relatively large brains in comparison to body mass.  Is it known if their cells express as much Neu5Gc as other mammals?</p>
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