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	<title>Comments on: In The Prebiotic Kitchen</title>
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	<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/</link>
	<description>A blog about life, past and future. Written by DISCOVER contributing editor and columnist Carl Zimmer.</description>
	<lastBuildDate>Mon, 09 Nov 2009 02:51:30 -0600</lastBuildDate>
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		<title>By: zuihitsu.org :: et cetera &#187; archive &#187; In The Beginning</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18155</link>
		<dc:creator>zuihitsu.org :: et cetera &#187; archive &#187; In The Beginning</dc:creator>
		<pubDate>Sun, 17 May 2009 00:13:13 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18155</guid>
		<description>[...] And so one more complex structure falls prey to nature&#8217;s cunning. For commentary, see here and here. [...]</description>
		<content:encoded><![CDATA[<p>[...] And so one more complex structure falls prey to nature&#8217;s cunning. For commentary, see here and here. [...]</p>
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		<title>By: Lello Islam</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18153</link>
		<dc:creator>Lello Islam</dc:creator>
		<pubDate>Sat, 16 May 2009 14:34:01 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18153</guid>
		<description>Agreed about retrosynthetic analysis. The problem with the earlier attempts to make ribonucleotides has been retrosynthetic analysis. Yes, RNA is structurally and constitutionally more difficult at first look, merely because the number of atoms in it, as well as the stereochemical complexity (i.e it&#039;s three dimensional shape), but in terms of chemistry so far it has been demonstrated to be generated quite efficiently. GNA has yet to be demonstrated to be created prebiotically. Just because something looks simple, doesn&#039;t mean it&#039;s easier to make. Likewise, the same problem exists with other &#039;minimal&#039; nucleic acids such as PNA and TNA. 

With respect to RNA and amino acids, a nice paper was published by Sutherland and Mullen I think in 2007 in a german chemistry journal, Angewandte Chemie, where they activate ribonucleotides, as well as make amino acid amides.</description>
		<content:encoded><![CDATA[<p>Agreed about retrosynthetic analysis. The problem with the earlier attempts to make ribonucleotides has been retrosynthetic analysis. Yes, RNA is structurally and constitutionally more difficult at first look, merely because the number of atoms in it, as well as the stereochemical complexity (i.e it&#8217;s three dimensional shape), but in terms of chemistry so far it has been demonstrated to be generated quite efficiently. GNA has yet to be demonstrated to be created prebiotically. Just because something looks simple, doesn&#8217;t mean it&#8217;s easier to make. Likewise, the same problem exists with other &#8216;minimal&#8217; nucleic acids such as PNA and TNA. </p>
<p>With respect to RNA and amino acids, a nice paper was published by Sutherland and Mullen I think in 2007 in a german chemistry journal, Angewandte Chemie, where they activate ribonucleotides, as well as make amino acid amides.</p>
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		<title>By: Sili</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18152</link>
		<dc:creator>Sili</dc:creator>
		<pubDate>Sat, 16 May 2009 14:21:21 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18152</guid>
		<description>This reminds me of how the initial attempt at synthesising vitamin B12 failed due to the wrong choice of retrosynthesis.

Years of work making two halves that then could not be joined.</description>
		<content:encoded><![CDATA[<p>This reminds me of how the initial attempt at synthesising vitamin B12 failed due to the wrong choice of retrosynthesis.</p>
<p>Years of work making two halves that then could not be joined.</p>
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		<title>By: Torbjörn Larsson, OM</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18141</link>
		<dc:creator>Torbjörn Larsson, OM</dc:creator>
		<pubDate>Fri, 15 May 2009 23:04:20 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18141</guid>
		<description>Nice writeup!

&lt;blockquote&gt;
In the so-called RNA world, this versatile molecule acted both like DNA (storing genetic information) and proteins (carrying out chemical reactions, such as building new RNA molecules).
&lt;/blockquote&gt;

One hypothesized task I&#039;ve seen is that RNA acts to concentrate and activate mono- or diamino acids, which likely preceded it. It is probable that in prebiotic chemistry a little bit of &#039;everything&#039; happened simultaneously. 

That is by the way a prediction that this result tests positive for as phospate isn&#039;t just an afterthought but contribute to the result. In the same sense, what is then less promising is that I hear they still had to purify in between steps.

Now I wonder if they could simplify (well, sort of since 4 reactions is really simple) by using glycine instead of ribose as backbone. GNA is a putative pre-RNA compound, doing the same task with an even simpler molecule. Again, perhaps initially both GNA and RNA was in play.</description>
		<content:encoded><![CDATA[<p>Nice writeup!</p>
<blockquote><p>
In the so-called RNA world, this versatile molecule acted both like DNA (storing genetic information) and proteins (carrying out chemical reactions, such as building new RNA molecules).
</p></blockquote>
<p>One hypothesized task I&#8217;ve seen is that RNA acts to concentrate and activate mono- or diamino acids, which likely preceded it. It is probable that in prebiotic chemistry a little bit of &#8216;everything&#8217; happened simultaneously. </p>
<p>That is by the way a prediction that this result tests positive for as phospate isn&#8217;t just an afterthought but contribute to the result. In the same sense, what is then less promising is that I hear they still had to purify in between steps.</p>
<p>Now I wonder if they could simplify (well, sort of since 4 reactions is really simple) by using glycine instead of ribose as backbone. GNA is a putative pre-RNA compound, doing the same task with an even simpler molecule. Again, perhaps initially both GNA and RNA was in play.</p>
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		<title>By: links for 2009-05-15 &#171; Amy G. Dala</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18130</link>
		<dc:creator>links for 2009-05-15 &#171; Amy G. Dala</dc:creator>
		<pubDate>Fri, 15 May 2009 14:01:22 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18130</guid>
		<description>[...] In The Prebiotic Kitchen &#124; The Loom &#124; Discover Magazine (tags: genetics research) [...]</description>
		<content:encoded><![CDATA[<p>[...] In The Prebiotic Kitchen | The Loom | Discover Magazine (tags: genetics research) [...]</p>
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		<title>By: Q ball</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18119</link>
		<dc:creator>Q ball</dc:creator>
		<pubDate>Thu, 14 May 2009 22:39:01 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18119</guid>
		<description>Thanks for this one, Carl!  I love the &quot;origins&quot; stuff.  Your proto-ribosome and viroid pieces were fantastic, and this one&#039;s a real gem.  Keep &#039;em coming!</description>
		<content:encoded><![CDATA[<p>Thanks for this one, Carl!  I love the &#8220;origins&#8221; stuff.  Your proto-ribosome and viroid pieces were fantastic, and this one&#8217;s a real gem.  Keep &#8216;em coming!</p>
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		<title>By: Want Soup? Try Prebiotic &#171; Good Tithings</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18114</link>
		<dc:creator>Want Soup? Try Prebiotic &#171; Good Tithings</dc:creator>
		<pubDate>Thu, 14 May 2009 16:31:52 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18114</guid>
		<description>[...] I love this stuff: [...]</description>
		<content:encoded><![CDATA[<p>[...] I love this stuff: [...]</p>
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		<title>By: RNA world &#171; Thesquaredcircle</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18113</link>
		<dc:creator>RNA world &#171; Thesquaredcircle</dc:creator>
		<pubDate>Thu, 14 May 2009 16:12:47 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18113</guid>
		<description>[...] till now. John Sutherland has come up with a chemical route by which RNA synthesis can take place.  Carl Zimmer of Discover magazine  does a great job of summarizing, as usual. Also, check out the article in NY times by  Nicholas [...]</description>
		<content:encoded><![CDATA[<p>[...] till now. John Sutherland has come up with a chemical route by which RNA synthesis can take place.  Carl Zimmer of Discover magazine  does a great job of summarizing, as usual. Also, check out the article in NY times by  Nicholas [...]</p>
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		<title>By: Lello Islam</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18107</link>
		<dc:creator>Lello Islam</dc:creator>
		<pubDate>Thu, 14 May 2009 07:30:19 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18107</guid>
		<description>Still not convinced by Panspermia. I&#039;ve just visited the wired.com website, and it&#039;s full of comments about this work being orchestrated by Obama.......please. 

This work has been ongoing for years. The conspiracy theories merely make me laugh, and smells of pathetiscm (even though it&#039;s not a real word I shall use it here). This is a bit like a bomb dropping on the heads of a creationist, metabolist or whatever other theory you believe in. 

Give me some hard facts, I&#039;m open minded and ready to be convinced.</description>
		<content:encoded><![CDATA[<p>Still not convinced by Panspermia. I&#8217;ve just visited the wired.com website, and it&#8217;s full of comments about this work being orchestrated by Obama&#8230;&#8230;.please. </p>
<p>This work has been ongoing for years. The conspiracy theories merely make me laugh, and smells of pathetiscm (even though it&#8217;s not a real word I shall use it here). This is a bit like a bomb dropping on the heads of a creationist, metabolist or whatever other theory you believe in. </p>
<p>Give me some hard facts, I&#8217;m open minded and ready to be convinced.</p>
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		<title>By: Mel</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18105</link>
		<dc:creator>Mel</dc:creator>
		<pubDate>Thu, 14 May 2009 03:42:58 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18105</guid>
		<description>Captain Kidd, that website appears to just link to whatever the person who maintains it thinks supports his position regardless of what is linked to actually says.  I see a lot of titles of recent journal articles that have nothing to do with panspermia, and can only be linked to it by very contorted thinking.  Frankly, it reeks of a person who has decided what the absolute truth is, and thus tries to fit the world to that notion.  That isn&#039;t science - it is bad post hoc reasoning of the sort found in creationism and conspiracy theories.  Try linking to some peer-reviewed papers that explicitly test predictions from panspermia and give actual evidence for it.
And in any case, SteveC is correct:  you are just moving the question.  Life had to start somewhere, and wherever it started, the question remains as to how.  Panspermia does not even start to get at that question (even when it is a seriously address hypothesis, which it certainly is not at that website to which you referred everyone).</description>
		<content:encoded><![CDATA[<p>Captain Kidd, that website appears to just link to whatever the person who maintains it thinks supports his position regardless of what is linked to actually says.  I see a lot of titles of recent journal articles that have nothing to do with panspermia, and can only be linked to it by very contorted thinking.  Frankly, it reeks of a person who has decided what the absolute truth is, and thus tries to fit the world to that notion.  That isn&#8217;t science &#8211; it is bad post hoc reasoning of the sort found in creationism and conspiracy theories.  Try linking to some peer-reviewed papers that explicitly test predictions from panspermia and give actual evidence for it.<br />
And in any case, SteveC is correct:  you are just moving the question.  Life had to start somewhere, and wherever it started, the question remains as to how.  Panspermia does not even start to get at that question (even when it is a seriously address hypothesis, which it certainly is not at that website to which you referred everyone).</p>
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		<title>By: The RNA World hypothesis just got a big boost &#171; Scary Reasoner</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18102</link>
		<dc:creator>The RNA World hypothesis just got a big boost &#171; Scary Reasoner</dc:creator>
		<pubDate>Thu, 14 May 2009 01:48:34 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18102</guid>
		<description>[...] Carl Zimmer does a great job of explaining it on his blog, &#8220;The Loom&#8221; The comments and bibliography there are worth checking out as well. [...]</description>
		<content:encoded><![CDATA[<p>[...] Carl Zimmer does a great job of explaining it on his blog, &#8220;The Loom&#8221; The comments and bibliography there are worth checking out as well. [...]</p>
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		<title>By: SteveC</title>
		<link>http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/comment-page-1/#comment-18101</link>
		<dc:creator>SteveC</dc:creator>
		<pubDate>Thu, 14 May 2009 01:41:41 +0000</pubDate>
		<guid isPermaLink="false">http://blogs.discovermagazine.com/loom/2009/05/13/in-the-prebiotic-kitchen/#comment-18101</guid>
		<description>Panspermia?  That doesn&#039;t answer the question.  It just moves it.</description>
		<content:encoded><![CDATA[<p>Panspermia?  That doesn&#8217;t answer the question.  It just moves it.</p>
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