Your inner viruses: the trickle becomes the flood

By Carl Zimmer | November 18, 2010 5:00 pm

Scientists have known for decades that the genomes of animals can sometimes harbor DNA from the viruses that have infected them. When I first learned of this fact some years ago, it blew my mind. The notion that any animal could be a little bit viral blurred nature’s boundaries.

The viruses that scientists discovered in host genomes were of a particular sort, known as endogenous retroviruses. Retroviruses, which include HIV and a number of viruses that can trigger cancer, have to insert their genetic material into their host’s genome in order to reproduce. The cell reads their genetic instructions along with its own, and then builds new viruses. It made a certain intuitive sense that retroviruses might sometimes get trapped in their host genomes, to be passed down from one generation to the next.

The first endogenous retroviruses scientists identified were still relatively functional. Under certain circumstances, their genes could still give rise to new viruses that could break out of their host cell. But gradually, scientists identified more and more fossil viruses, which had mutated so much that they could no longer reproduce. As I wrote in the New York Times in 2006, scientists have even figured out how to resurrect these fossil viruses from the human genome.

That would have been weird enough. But nature is generous with its weirdness. As I wrote in the Times earlier this year, scientists have started finding viral stretches of DNA in our genomes that are not retroviruses. In that article, I focused on the discovery of genes from bornaviruses, which just park themselves next to our DNA, rather than inserting their genes into our own.

New kinds of endogenous viruses keep turning up as scientists looked closer. Today in the journal PLOS Genetics, Aris Katzourakis of the University of Oxford and Robert Gifford of New York University offer a particularly startling survey of the viral world within. Rather than searching for one particular kind of virus, they hunted for a wide range of them. Their collection reflected all the different ways that viruses can replicate inside mammal cells. They then hunted for the sequences of these viruses in the genomes of 44 mammal species, plus a handful of birds and invertebrates. The scientists struck viral gold. Every major group of viruses turned up in the host genomes.

In most cases, the viruses infected their own host. But the scientists also found mammal viruses integrated into the genomes of ticks and mosquitoes–perhaps as a result of their feeding on virus-infected mammal blood. In many cases, viruses slipped into their host genomes a long, long time ago. The scientists discovered segments of bornavirus present not just in humans, but in monkeys from the Old World and New World. We share a common ancestor with monkeys that lived some 54 million years ago. What’s more, one of these bornavirus segments is very similar in many of its hosts today. That uniformity suggests that it has taken on a useful function in our own bodies. Scientists have already found evidence that endogenous viruses can help build placentas and fight off other viruses; now bornaviruses can be added to the list.

This is one of those exploding fields that is a joy to follow. I’m glad that this new paper came out before I had to turn in my proofs for my next book, called A Planet of Viruses, which will be coming out in May. But I’m sure that the catalog of inner viruses will be growing a lot longer in years to come.

[Update: Ed Yong is also infected with curiosity.]

Comments (13)

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  1. Daniel J. Andrews

    Will your new book also be an e-book? Or is it too soon to know yet?

  2. Matt Devereux

    When I heard that the human genome contained viral DNA, my first thought was: Could colds and ‘flu’ be coming from within as well as being generally contagious? Consider the idea that these things may emerge more than once, after dormancies of a generation or more. Parasite-host relationships can be plenty weird, so why not?

    [CZ: Matt--I'd be very doubtful of that. These insertions into the genome that get passed down through the germline are extremely rare. Over millions of years they do pile up, but on the scale of years, they almost never happen. What's more, influenza and cold viruses did not turn up in this survey.]

  3. natselrox

    Looking forward to CZ’s book. What piqued my interest in paleovirology and retroviruses in general was Frank Ryan’s ‘Virolution’. Interested people might take a look.

  4. Dan [1]– I’ll deliver those details in a couple months. Right now I have to finish going through the proofs!

  5. Its a big virus day at discover, its a nice boom. I’d get started on the next book to keep it relevant!

  6. Steviepinhead

    Carl, I think you are missing a word (include?) in the sentence, “Retroviruses, which [?] HIV and a number of viruses that can trigger cancer, …”.

  7. Daniel J. Andrews

    Thanks Carl. I figured it would be a bit too soon for those kind of details.

    I was visiting my mom and telling her about these findings, and she asked if it was possible some viruses originated in our (animal) DNA and were incorporated by other vectors and eventually broke free to spread to other organisms like a true virus. And, she wondered, since so much behaviour seems to be programmed into the brain (e.g. birds, fish migrating to areas they’ve never been before), is it possible for some types of knowledge to be transmitted in a viral-like manner?

    My limited knowledge on the subject thinks ‘not likely’, but fun to think about, and maybe even inspire a fiction story.

  8. Karen

    So happy you are doing a book on this topic!

  9. Hog

    If acquired viral genomic sequences are not transmitted to germ cells, it means we die with a larger genome than the one we were born with…
    Which doesn’t seem true.
    Probably most acquired viral genomic sequences are only temporarily hosted by our genome.

  10. Viral DNA has also infiltrated the human genome: Taking a different approach than the Katzourakis and Gifford paper, translated viral genomes (herpes simplex and other herpes viruses, influenza and the common cold virus, and many others) were compared to the human proteome by BLAST analysis. Thousands of short contiguous pentapeptide sequences , and sometimes greater, are littered throughout the human proteome, and in fact the human genome appears to be composed almost entirely of viral DNA. This evidently has important implications for evolution.

    In response to Hogg’s comment, human Herpes virus 6 can be transmitted from parent to child via chromosomal integration, so yes, our genomes can enlarge. Tanaka-Taya et al 2004 http://www.ncbi.nlm.nih.gov/pubmed/15170644, and given the extensive homology between human and viral DNA, must have been doing so for millions of years. Infection, which may insert multiple gene fragments at once may be what has been, and still is, driving evolution.

    The protein homology is also critical to our understanding of disease: Current viruses express proteins that are similar to our own, and upon infection will be able to act as dummy ligands, decoy receptors or enzymes, and will also interfere with protein/protein interaction networks. Such homologous viral inserts are likely to play a key role in a multitude of human diseases.

    The BLAST analyses, representing over a million such alignments, can be viewed at http://www.polygenicpathways.co.uk/BLASTS.htm

    and some of the consequences are discussed in a series of prepublications at NaturePrecedings

    http://precedings.nature.com/users/c8e325bfe6bd1d4fc6e006ff204b5f19

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The Loom

A blog about life, past and future. Written by DISCOVER contributing editor and columnist Carl Zimmer.

About Carl Zimmer

Carl Zimmer writes about science regularly for The New York Times and magazines such as DISCOVER, which also hosts his blog, The LoomHe is the author of 12 books, the most recent of which is Science Ink: Tattoos of the Science Obsessed.

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