Visualizing The Connected Brain

By Neuroskeptic | February 8, 2012 8:33 am

So it seems as though the “connectome” is the latest big thing in neuroscience. This is the brain’s wiring diagram, in terms of the connections between neurons and on a larger scale, between brain regions.

We certainly won’t understand the brain without getting to grips with the connections but equally, it’s not the whole story. I previously emphasised that the brain is not made of soup; it’s not made of spaghetti, either.

Connectomics does however unquestionably provide some of the prettiest images in neuroscience. And they just got prettier, with a new technique for visualizing connections, just revealed in Neuroimage: Circular representation of human cortical networks for subject and population-level connectomic visualization.

See above. It’s a rather lovely vista (for which the authors Irimia et al share credit with the folks behind the Circos visualization tool they used).

All you need are some MRI scans, and a lot of image processing, and you can produce one of these “Connectograms”. But what does it mean? Here’s the authors’ description:

The outermost ring shows the various brain regions arranged by lobe (fr — frontal; ins — insula; lim — limbic; tem — temporal; par — parietal; occ — occipital; nc — non-cortical; bs — brain stem; CeB — cerebellum) and further ordered anterior-to-posterior. The color map of each region is lobe-speci?c and maps to the color of each regional parcellation.

In other words, the outer ring is just a list of brain regions, each with an assigned colour. The inner rings tell us about those regions:

Proceeding inward towards the center of the circle, these measures are: total GM volume, total area of the surface associated with the GM–WM interface (at the base of the cortical ribbon), mean cortical thickness, mean curvature and connectivity per unit volume. For non-cortical regions, only average regional volume is shown.

So each of the five inner rings displays data about one aspect of brain anatomy, for each of the regions. The colors are a heat map of the numbers.

Finally, the lines between regions represent the degrees of connectivity between regions via white matter tracts, as measured with diffusion tensor imaging:

The links represent the computed degrees of connectivity between segmented brain regions. Links shaded in blue represent DTI tractography pathways in the lower third of the distribution of FA, green lines the middle third, and red lines the top third (see text for details).

You can also make a pooled connectogram of the average neuroanatomy across a group of people. Still, it remains to be seen whether these are as useful as they are beautiful.

ResearchBlogging.orgIrimia A, Chambers MC, Torgerson CM, and Van Horn JD (2012). Circular representation of human cortical networks for subject and population-level connectomic visualization. NeuroImage PMID: 22305988

CATEGORIZED UNDER: fMRI, methods, papers
  • Anonymous

    But it still doesn't tell us HOW the brain works. Perhaps you should pay some more attention to cellular connectomics.

  • DS

    Neuroskeptic wrote;

    “Still, it remains to be seen whether these are as useful as they are beautiful.”

    Hmm. I think that should be changed to: Still it remains to be seen whether these are as valid as they are beautiful.

  • Ivana Fulli MD
  • DAD

    No wonder I'm confused.

  • Anonymous

    This is the most ridiculous thing I've ever seen. How stupid.

  • Anonymous

    You know, its actually a pretty clever way to show both the anatomical and connectivity relationships between disparate regions of the brain. Cudos to these authors for thinking this up.

  • Anonymous

    Hey, the brain is complicated. These authors aren't saying it isn't. I bet we see brain circles all over the place soon enough.

  • JamesID

    These authors are losers. I hope they get voted off the neuroscience island for this crap.

  • http://www.blogger.com/profile/06647064768789308157 Neuroskeptic

    What just happened? Is that really four different people commenting within 10 minutes, or one who can't make up their mind?

    I do like the idea of Neuroscience Island though. Although it should be Neuroscience (Pen)insula.

  • http://www.blogger.com/profile/00782852952891496899 neuroaholic

    this is cool. Very useful for creating a summary of findings. thanks for sharing.

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Neuroskeptic

No brain. No gain.

About Neuroskeptic

Neuroskeptic is a British neuroscientist who takes a skeptical look at his own field, and beyond. His blog offers a look at the latest developments in neuroscience, psychiatry and psychology through a critical lens.

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