Can Monkeys Get Depressed?

By Neuroskeptic | March 20, 2015 5:19 pm

According to a new study from Chinese neuroscientists Fan Xu and colleagues, some monkeys can experience depression in a similar way to humans.

The researchers studied cynomolgus monkeys, also known as crab-eating macaques (Macaca fascicularis), a species native to Southeast Asia. Cynomolgus monkeys are highly social animals. Xu et al. previously showed that isolating a monkey from its companions caused it to develop depression-like behaviors. In their new paper, the authors say that they’ve noticed that some monkeys seem to become depressed naturally, without any human intervention.

They observed the monkeys in a large primate breeding facility in Suzhou, China:

From April to November 2010, by means of a scanning method on a total population of 1007 adult female cynomolgus monkeys across all 52 enclosures, we identified subjects displaying depressive behavior using the following operational definition: slumped or collapsed body posture, diminished interest in feeding and sex, and diminished communication and reciprocal grooming with others. In total, 50 subjects met these criteria.

Here’s Xu et al.’s illustration of the slouched posture of two “depressed” monkeys as compared to a happy one

depressed_monkeys

Some of the descriptions of the behavior of the pessimistic primates are rather poignant:

NOD subjects more often selected safer and more remote places to feed (i.e., ‘feeding while hanging’) to avoid confrontation. Second, in terms of resting behaviors, NOD subjects selected safer and more remote areas to rest… NOD subjects spent more time on solitary huddling or embracing a conspecific (i.e., ‘huddling’ / ‘embracing’).

Xu et al. argue that the melancholy macaques represent a close analog of human depression because

Similar to many modern human societies, scarce resources that form the basis of stress-inducing social competition (e.g., food, sex) are unevenly distributed among different social classes…  our model involves chronic mild psychosocial stressors that are randomly distributed throughout daily social life that accumulate over time.

Hmm. The analogy between modern society and a monkey enclosure does have a certain face validity. But who are we to say whether these monkeys are suffering from “depression” (pathological) as opposed to “sadness” (normal emotional response)? This is a notoriously difficult distinction to draw in humans, let alone in monkeys! While these animals certainly appear to be miserable, maybe they are just a model for human misery, not human mental illness.

ResearchBlogging.orgXu F, Wu Q, Xie L, Gong W, Zhang J, Zheng P, Zhou Q, Ji Y, Wang T, Li X, Fang L, Li Q, Yang D, Li J, Melgiri ND, Shively C, & Xie P (2015). Macaques exhibit a naturally-occurring depression similar to humans. Scientific Reports, 5 PMID: 25783476

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Neuroskeptic is a British neuroscientist who takes a skeptical look at his own field, and beyond. His blog offers a look at the latest developments in neuroscience, psychiatry and psychology through a critical lens.

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