http://blogs.discovermagazine.com/notrocketscience/2009/08/10/flu-and-parkinsons-how-h5n1-bird-flu-causes-neural-degeneration-in-mice/ Mon, 26 Nov 2012 12:00:51 +0000 hourly 1 http://wordpress.org/?v=3.4.2 http://blogs.discovermagazine.com/notrocketscience/2009/08/10/flu-and-parkinsons-how-h5n1-bird-flu-causes-neural-degeneration-in-mice/#comment-4487 passionlessDrone Tue, 11 Aug 2009 01:44:52 +0000 http://blogs.discovermagazine.com/notrocketscience/2009/08/10/flu-and-parkinsons-how-h5n1-bird-flu-causes-neural-degeneration-in-mice/#comment-4487 Hi Ed - Long time lurker, first time poster. Interestingly enough, there is evidence for microglial priming and subsequent succeptibility to a second hit in seizures as well: <a href="http://www.ncbi.nlm.nih.gov/pubmed/19501063?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed" rel="nofollow">Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model</a> <a href="http://www.ncbi.nlm.nih.gov/pubmed/17521344?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed" rel="nofollow">Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation</a> Anyways, you are my favorite blogger. Thank you and please keep it up! - pD Hi Ed -
Long time lurker, first time poster.
Interestingly enough, there is evidence for microglial priming and subsequent succeptibility to a second hit in seizures as well:
Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a ‘two-hit’ seizure model
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation
Anyways, you are my favorite blogger. Thank you and please keep it up!
- pD

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