Comments on: The Shock and Awe Approach to Delivering DNA Vaccines http://blogs.discovermagazine.com/sciencenotfiction/2010/08/09/the-shock-and-awe-approach-to-delivering-dna-vaccines/ Wed, 22 Feb 2012 16:57:08 +0000 hourly 1 http://wordpress.org/?v=3.4.2 By: Ryan P. Jama http://blogs.discovermagazine.com/sciencenotfiction/2010/08/09/the-shock-and-awe-approach-to-delivering-dna-vaccines/#comment-2971 Ryan P. Jama Sun, 05 Jun 2011 10:00:49 +0000 http://blogs.discovermagazine.com/sciencenotfiction/?p=1596#comment-2971 Thankyou for this marvelous post, I am glad I observed this web site on yahoo. Thankyou for this marvelous post, I am glad I observed this web site on yahoo.

]]> By: ZvvZ http://blogs.discovermagazine.com/sciencenotfiction/2010/08/09/the-shock-and-awe-approach-to-delivering-dna-vaccines/#comment-2970 ZvvZ Thu, 02 Sep 2010 03:56:39 +0000 http://blogs.discovermagazine.com/sciencenotfiction/?p=1596#comment-2970 The DNA vaccines have various advantages. They allow creation of vaccines based on genes shared by all strains ("consensus" genes) rather than requiring growth of many different strains. They don't use a killed or attenuated sample. They don't require cold storage. They are very good at generating T-cell responses that kill cells that have been infected before they can complete the cycle. They can be used to treat existing diseases as well as being used as a preventative. There are other advantages as well over most conventional vaccines. The DNA vaccines have various advantages.

They allow creation of vaccines based on genes shared by all strains (“consensus” genes) rather than requiring growth of many different strains.
They don’t use a killed or attenuated sample.
They don’t require cold storage.
They are very good at generating T-cell responses that kill cells that have been infected before they can complete the cycle. They can be used to treat existing diseases as well as being used as a preventative.

There are other advantages as well over most conventional vaccines.

]]> By: ToneDeF http://blogs.discovermagazine.com/sciencenotfiction/2010/08/09/the-shock-and-awe-approach-to-delivering-dna-vaccines/#comment-2969 ToneDeF Mon, 09 Aug 2010 18:50:47 +0000 http://blogs.discovermagazine.com/sciencenotfiction/?p=1596#comment-2969 The reason most vaccines, including flu vaccines, currently take so long to produce is that they are manufactured using chicken eggs, which takes quite a few months to mature and are consume a lot of space while incubating. They can be generated much quicker using traditional biotechnology techniques like fermenting in large tanks (like beer). I think the reason they aren't are more related to regulatory issues (ie FDA). If industry and government agencies would allow for quicker production of traditional vaccines, I'm not sure if there is any advantage to DNA vaccines in most cases. The reason most vaccines, including flu vaccines, currently take so long to produce is that they are manufactured using chicken eggs, which takes quite a few months to mature and are consume a lot of space while incubating. They can be generated much quicker using traditional biotechnology techniques like fermenting in large tanks (like beer). I think the reason they aren’t are more related to regulatory issues (ie FDA).

If industry and government agencies would allow for quicker production of traditional vaccines, I’m not sure if there is any advantage to DNA vaccines in most cases.

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